Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Julien, Pothier"'
Autor:
Sébastien Jeay, Stefan Diethelm, Agnes Knopf, Marie Goxe, Marie Daugan, Julie Erupathil, Julien Pothier, Davide Pozzi, Thierry Sifferlen, Lorenza Wyder, Isabelle Lyothier, Olivier Corminboeuf, Francois Lehembre, Imke Renz, Dominique Meyer
Publikováno v:
Cancer Research. 83:1809-1809
Prostaglandin E2 (PGE2) binds to four G-protein-coupled EP receptors, of which both EP2 and EP4 are abundantly expressed by tumor-infiltrating immune cells including DCs, NK cells, Tregs, cytotoxic T cells and TAMs. Signaling via EP2 and EP4 is immun
Autor:
Carina Lotz-Jenne, Sylvaine Cren, Christoph Joesch, Sabine Ackerknecht, Jennifer Brandes, Claire Moebs, Dominik Hartl, Felix Hartrampf, Philippe Guerry, Julien Pothier, Alexia Chavanton-Arpel
Publikováno v:
Cancer Immunology Research. 10:B66-B66
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2) catalyze the oxidation of L-Tryptophan (TRP) leading to the formation of immunosuppressive kynurenine (KYN) pathway metabolites. According to TCGA, a substantial fraction of d
Autor:
Sylvia Richard-Bildstein, Gabriel Schäfer, Laetitia Pouzol, Eleanor Lindenberg, François Lehembre, Hamed Aissaoui, Julien Pothier, Philippe Guerry, Carmela Gnerre
Publikováno v:
Journal of Medicinal Chemistry. 63:15864-15882
The chemokine receptor CXCR7, also known as ACKR3, is a seven-transmembrane G-protein-coupled receptor (GPCR) involved in various pathologies such as neurological diseases, autoimmune diseases, and cancers. By binding and scavenging the chemokines CX
Publikováno v:
Journal of Medicinal Chemistry. 58:8011-8035
Various racemic and enantioenriched (trans)-X,Y-dihydroxy-X,Y-dihydronaphthoyl analogues as well as X-hydroxy-naphthoyl analogues of CRTh2 antagonist 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid (1, Setipiprant/A
Autor:
Heinz Fretz, Xavier Leroy, Carmela Gnerre, Kurt Hilpert, Julien Pothier, Markus A. Riederer, Anja Valdenaire, Oliver Peter
Publikováno v:
Journal of Medicinal Chemistry. 56:4899-4911
Herein we describe the discovery of the novel CRTh2 antagonist 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid 28 (setipiprant/ACT-129968), a clinical development candidate for the treatment of asthma and seasonal a
Autor:
Markus A. Riederer, Anja Valdenaire, Heinz Fretz, Julien Pothier, Xavier Leroy, Carmela Gnerre, Oliver Peter, Dorte Renneberg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:944-948
(E)-2-(3-(3-((3-Bromophenyl)amino)-2-cyano-3-oxoprop-1-en-1-yl)-1H-indol-1-yl)acetic acid (1) was discovered in a HTS campaign for CRTh2 receptor antagonists. An SAR around this hit could be established and representatives with interesting activity p
Autor:
Heinz Fretz, Xavier Leroy, Carmela Gnerre, Markus A. Riederer, Anja Valdenaire, Oliver Peter, Julien Pothier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4660-4664
Hit-to-lead evolution of 2-(2-((2-(4-chlorophenoxy)ethyl)thio)-1H-benzo[d]imidazol-1-yl)acetic acid (1), discovered in a high-throughput screening campaign as a novel chemotype of CRTh2 receptor antagonist, is presented. SAR development as well as in
Publikováno v:
Tetrahedron. 60:3231-3241
A range of acidic Molecularly Imprinted Polymers (MIPs) were synthesised using the imprint molecule trans-carvyl amine as a transition state analogue for the selective isomerisation of alpha-pinene oxide to trans-carveol. The amine functionality of t
Publikováno v:
Tetrahedron Letters. 40:3701-3704
A highly convergent approach has been developed for the construction of various nitrogen heterocycles using as the key step the intermolecular addition of an α-ketonyl radical onto a suitably protected allylic or homoallylic amine.
Publikováno v:
ChemInform. 30
A highly convergent approach has been developed for the construction of various nitrogen heterocycles using as the key step the intermolecular addition of an α-ketonyl radical onto a suitably protected allylic or homoallylic amine.