Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Julien, Cachat"'
Autor:
Julien Cachat, Christine Deffert, Marco Alessandrini, Pascale Roux-Lombard, Audrey Le Gouellec, Marie-José Stasia, Stéphanie Hugues, Karl-Heinz Krause
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Chronic granulomatous disease (CGD) is a primary immunodeficiency resulting from loss of function mutations in the reactive oxygen species generating phagocyte NADPH oxidase (NOX2). CGD patients are prone to infection, but also have an increased susc
Externí odkaz:
https://doaj.org/article/bf3a4195f860457086ff73794890231e
Autor:
Marcos de Lima, Florent Malard, Eduardo Olavarria, Estefanía Pérez López, Michael Medinger, Elisabeth Kueenburg, Malika Souquieres, Julien Cachat, Christos Stylianou, Patrice Chevallier
Publikováno v:
Blood. 140:12936-12937
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e78eef437c31e7b421f7fe0865407ba2
https://doi.org/10.1182/blood-2022-159785
https://doi.org/10.1182/blood-2022-159785
Autor:
Christine Deffert, Michela G Schäppi, Jean-Claude Pache, Julien Cachat, Dominique Vesin, Ruth Bisig, Xiaojuan Ma Mulone, Tiina Kelkka, Rikard Holmdahl, Irene Garcia, Maria L Olleros, Karl-Heinz Krause
Publikováno v:
PLoS Pathogens, Vol 10, Iss 9, p e1004325 (2014)
Patients with chronic granulomatous disease (CGD) lack generation of reactive oxygen species (ROS) through the phagocyte NADPH oxidase NOX2. CGD is an immune deficiency that leads to frequent infections with certain pathogens; this is well documented
Externí odkaz:
https://doaj.org/article/081c7d7b8e9041248ba6eb5f5b151381
Autor:
Saleh Al-Ghamdi, Abdulkader Albasri, Julien Cachat, Salih Ibrahem, Belal A Muhammad, Darryl Jackson, Abdolrahman S Nateri, Karin B Kindle, Mohammad Ilyas
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20919 (2011)
CTEN/TNS4 is an oncogene in colorectal cancer (CRC) which enhances cell motility although the mechanism of Cten regulation is unknown. We found an association between high Cten expression and KRAS/BRAF mutation in a series of CRC cell lines (p = 0.03
Externí odkaz:
https://doaj.org/article/a5830d31eb4248f49856fc4e682174c0
Publikováno v:
Clinical science (London England : 1979)
Clinical Science, Vol. 128, No 10 (2015) pp. 635-648
Clinical Science, Vol. 128, No 10 (2015) pp. 635-648
The phagocyte NADPH oxidase NOX2 produces reactive oxygen species (ROS) and is a well-known player in host defence. However, there is also increasing evidence for a regulatory role of NOX2 in adaptive immunity. Deficiency in phagocyte NADPH oxidase c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0875f1cdad9616359e0fa819ba1226
Autor:
Christelle Tissot, Candice Trocmé, Stephanie Carnesecchi, Julien Cachat, Karl-Heinz Krause, Sylvie Papacatzis, Christine Deffert, Rikard Holmdahl, Yves Donati, Vincent Braunersreuther, Jean-Claude Pache, Constance Barazzone-Argiroffo
Publikováno v:
The Journal of pathology
The Journal of Pathology, Vol. 235, No 1 (2015) pp. 65-78
The Journal of Pathology
JOURNAL OF PATHOLOGY
The Journal of Pathology, Vol. 235, No 1 (2015) pp. 65-78
The Journal of Pathology
JOURNAL OF PATHOLOGY
Reactive oxygen species (ROS) participate in the pathogenesis of emphysema. Among ROS-producing enzymes, NOX NADPH oxidases are thought to be responsible for tissue injury associated with several lung pathologies. To determine whether NOX2 and/or NOX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e11ca8e327bdba70d328144fbc66a5
Autor:
Suranjith L. Seneviratne, Nikolay V. Ogryzko, Katherine L. Hammond, Krisztina Hegyi, Bas G.J. Surewaard, M. Estée Török, Michael Otto, Tor Ny, Robin Antrobus, Pablo Moreno, Simon J. Foster, Petros Ligoxygakis, John E. Connolly, Lucy Hepburn, Karen Brown, Lihui Wang, Clare E. Bryant, Stephen A. Renshaw, Mark Schiebler, Arthur Kaser, Liliana Minichiello, Catherine Klapholz, Dorothy M Grogono, Sharon J. Peacock, C. Geoff Woods, Bernardo Montano Ochoa, Julien Cachat, Tomasz K. Prajsnar, Matthew T. G. Holden, Tom L. Blundell, Catherine A. Loynes, R. Andres Floto
Publikováno v:
Science. 346:641-646
Many key components of innate immunity to infection are shared between Drosophila and humans. However, the fly Toll ligand Spaetzle is not thought to have a vertebrate equivalent. We have found that the structurally related cystine-knot protein, nerv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afce01bf6af10338892b259ddfa25667
https://doi.org/10.1126/science.1258705
https://doi.org/10.1126/science.1258705
Publikováno v:
Cellular Microbiology. 16:1168-1178
Infection of humans with Mycobacterium tuberculosis remains frequent and may still lead to death. After primary infection, the immune system is often able to control M. tuberculosis infection over a prolonged latency period, but a decrease in immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0503f91971a9b327143c8359d661a3e
https://doi.org/10.1111/cmi.12322
https://doi.org/10.1111/cmi.12322
Autor:
Lucy, Hepburn, Tomasz K, Prajsnar, Catherine, Klapholz, Pablo, Moreno, Catherine A, Loynes, Nikolay V, Ogryzko, Karen, Brown, Mark, Schiebler, Krisztina, Hegyi, Robin, Antrobus, Katherine L, Hammond, John, Connolly, Bernardo, Ochoa, Clare, Bryant, Michael, Otto, Bas, Surewaard, Suranjith L, Seneviratne, Dorothy M, Grogono, Julien, Cachat, Tor, Ny, Arthur, Kaser, M Estée, Török, Sharon J, Peacock, Matthew, Holden, Tom, Blundell, Lihui, Wang, Petros, Ligoxygakis, Liliana, Minichiello, C Geoff, Woods, Simon J, Foster, Stephen A, Renshaw, R Andres, Floto
Publikováno v:
Science (New York, N.Y.). 346(6209)
Many key components of innate immunity to infection are shared between Drosophila and humans. However, the fly Toll ligand Spaetzle is not thought to have a vertebrate equivalent. We have found that the structurally related cystine-knot protein, nerv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3bbd364aab050fd7577f4c40043aa2d
https://pubmed.ncbi.nlm.nih.gov/25359976
https://pubmed.ncbi.nlm.nih.gov/25359976
C-terminal tensin-like gene functions as an oncogene and promotes cell motility in pancreatic cancer
Autor:
Mohammad Ilyas, Malcolm R. Alison, Karin B. Kindle, Mohammed Ahmed, Darryl Jackson, Saleh Al-Ghamdi, William R. Otto, Abdulkader M. Albasri, Abed M. Zaitoun, Naomi Guppy, Julien Cachat
Publikováno v:
Pancreas. 42(1)
Objectives C-terminal tensin-like gene (CTEN, also known as TNS4) localizes to focal adhesions and is reported to function as an oncogene in colonic, breast, lung, and gastric cancers. Its role in pancreatic cancer is unknown and was thus investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0d39b41f978c25d940edf853334e4f
https://pubmed.ncbi.nlm.nih.gov/22750970
https://pubmed.ncbi.nlm.nih.gov/22750970