Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Julien, Ablain"'
Autor:
Amira Al Mahi, Julien Ablain
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 2 (2022)
Activating mutations in RAS genes are the most common genetic driver of human cancers. Yet, drugging this small GTPase has proven extremely challenging and therapeutic strategies targeting these recurrent alterations have long had limited success. To
Externí odkaz:
https://doaj.org/article/850d8f8c772c456daa253a54abb1a4fc
Autor:
Jiyeon Choi, Tongwu Zhang, Andrew Vu, Julien Ablain, Matthew M. Makowski, Leandro M. Colli, Mai Xu, Rebecca C. Hennessey, Jinhu Yin, Harriet Rothschild, Cathrin Gräwe, Michael A. Kovacs, Karen M. Funderburk, Myriam Brossard, John Taylor, Bogdan Pasaniuc, Raj Chari, Stephen J. Chanock, Clive J. Hoggart, Florence Demenais, Jennifer H. Barrett, Matthew H. Law, Mark M. Iles, Kai Yu, Michiel Vermeulen, Leonard I. Zon, Kevin M. Brown
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
There are more than 20 known melanoma susceptibility genes. Here, using a massively parallel reporter assay, the authors identify risk-associated variants that alter gene transcription, and demonstrate that expression of one such gene, MX2, leads to
Externí odkaz:
https://doaj.org/article/670b26b5d219499083d912a34bb1bf00
Autor:
Maurizio Fazio, Ellen van Rooijen, Michelle Dang, Glenn van de Hoek, Julien Ablain, Jeffrey K Mito, Song Yang, Andrew Thomas, Jonathan Michael, Tania Fabo, Rodsy Modhurima, Patrizia Pessina, Charles K Kaufman, Yi Zhou, Richard M White, Leonard I Zon
Publikováno v:
eLife, Vol 10 (2021)
Recent genomic and scRNA-seq analyses of melanoma demonstrated a lack of recurrent genetic drivers of metastasis, while identifying common transcriptional states correlating with invasion or drug resistance. To test whether transcriptional adaptation
Externí odkaz:
https://doaj.org/article/b2a52bd0b3874cc18579f387a8732b1a
Autor:
Lucia Altucci, Hendrik G. Stunnenberg, Antonello Mai, Angela Nebbioso, Hugues de Thé, Joost H.A. Martens, Amit Mandoli, Yves Collette, Armelle Goubard, Rèmy Castellano, Sergio Valente, Julien Ablain, Kees-Jan Françoijs, Filomena Matarese, Francesca Petraglia, Dante Rotili, Mariarosaria Conte, Vincenzo Carafa, Floriana De Bellis
PDF file - 187KB, MC2392 specificity and selectivity for PML-RARalpha binding sites.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01570aa5beaf5d1236dfaa65d1545486
https://doi.org/10.1158/0008-5472.22402034.v1
https://doi.org/10.1158/0008-5472.22402034.v1
Autor:
Lucia Altucci, Hendrik G. Stunnenberg, Antonello Mai, Angela Nebbioso, Hugues de Thé, Joost H.A. Martens, Amit Mandoli, Yves Collette, Armelle Goubard, Rèmy Castellano, Sergio Valente, Julien Ablain, Kees-Jan Françoijs, Filomena Matarese, Francesca Petraglia, Dante Rotili, Mariarosaria Conte, Vincenzo Carafa, Floriana De Bellis
PDF file - 160KB, Supplemental Materials and Methods. Supplemental Table 1. Primers. Supplemental Table 2. Analysis of the transcription level of the 148 genes associated with apoptosis revealed main differences between ATRA and MC2392. Supplemental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c5b5ff82d5bf331ecffc9a94b92383
https://doi.org/10.1158/0008-5472.22402022
https://doi.org/10.1158/0008-5472.22402022
Autor:
Lucia Altucci, Hendrik G. Stunnenberg, Antonello Mai, Angela Nebbioso, Hugues de Thé, Joost H.A. Martens, Amit Mandoli, Yves Collette, Armelle Goubard, Rèmy Castellano, Sergio Valente, Julien Ablain, Kees-Jan Françoijs, Filomena Matarese, Francesca Petraglia, Dante Rotili, Mariarosaria Conte, Vincenzo Carafa, Floriana De Bellis
PDF file - 147KB, Differences in gene expression between ATRA and MC2392.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c4b2087fac9aba4910d7f5033d708b
https://doi.org/10.1158/0008-5472.22402031.v1
https://doi.org/10.1158/0008-5472.22402031.v1
Autor:
Lucia Altucci, Hendrik G. Stunnenberg, Antonello Mai, Angela Nebbioso, Hugues de Thé, Joost H.A. Martens, Amit Mandoli, Yves Collette, Armelle Goubard, Rèmy Castellano, Sergio Valente, Julien Ablain, Kees-Jan Françoijs, Filomena Matarese, Francesca Petraglia, Dante Rotili, Mariarosaria Conte, Vincenzo Carafa, Floriana De Bellis
HDAC inhibitors (HDACi) are widely used in the clinic to sensitize tumorigenic cells for treatment with other anticancer compounds. The major drawback of HDACi is the broad inhibition of the plethora of HDAC-containing complexes. In acute promyelocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::222bc685873ac643ad91428065d40628
https://doi.org/10.1158/0008-5472.c.6505973
https://doi.org/10.1158/0008-5472.c.6505973
Autor:
Lucia Altucci, Hendrik G. Stunnenberg, Antonello Mai, Angela Nebbioso, Hugues de Thé, Joost H.A. Martens, Amit Mandoli, Yves Collette, Armelle Goubard, Rèmy Castellano, Sergio Valente, Julien Ablain, Kees-Jan Françoijs, Filomena Matarese, Francesca Petraglia, Dante Rotili, Mariarosaria Conte, Vincenzo Carafa, Floriana De Bellis
PDF file - 37KB, ChIP analysis for MC2392 specific target genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ff69aa04d8dee3bf3ff16ca242297c
https://doi.org/10.1158/0008-5472.22402028.v1
https://doi.org/10.1158/0008-5472.22402028.v1
Autor:
Lucia Altucci, Hendrik G. Stunnenberg, Antonello Mai, Angela Nebbioso, Hugues de Thé, Joost H.A. Martens, Amit Mandoli, Yves Collette, Armelle Goubard, Rèmy Castellano, Sergio Valente, Julien Ablain, Kees-Jan Françoijs, Filomena Matarese, Francesca Petraglia, Dante Rotili, Mariarosaria Conte, Vincenzo Carafa, Floriana De Bellis
PDF file - 91KB, Death pathways modulation by MC2392.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ac3690db2e33f1d8cedf8d44d7c602
https://doi.org/10.1158/0008-5472.22402025
https://doi.org/10.1158/0008-5472.22402025
Autor:
Julien Ablain, Amira Al Mahi, Harriet Rothschild, Meera Prasad, Sophie Aires, Song Yang, Maxim E. Dokukin, Shuyun Xu, Michelle Dang, Igor Sokolov, Christine G. Lian, Leonard I. Zon
Publikováno v:
Nature Genetics
Nature Genetics, 2022, 54 (12), pp.1839-1852. ⟨10.1038/s41588-022-01191-z⟩
Nature Genetics, 2022, 54 (12), pp.1839-1852. ⟨10.1038/s41588-022-01191-z⟩
Cancer genetics has uncovered many tumor-suppressor and oncogenic pathways, but few alterations have revealed mechanisms involved in tumor spreading. Here, we examined the role of the third most significant chromosomal deletion in human melanoma that