Výsledky vyhledávání - "Julie Y. Reuther"

Oncoprotein Suppression of Tumor Necrosis Factor-induced NFκB Activation Is Independent of Raf-controlled Pathways

Autor: Albert S. Baldwin, Julie Y. Reuther-Madrid, Vasiliki Anest, Julie L. Hanson

Publikováno v: Journal of Biological Chemistry. 278:34910-34917

Extensive data indicate that the transcription factor NF kappa B is activated by signals downstream of oncoproteins such as Ras or breakpoint cluster region (BCR)-ABL. Consistent with this, evidence has been presented that NF kappa B activity is requ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf28bac68cf8276ff7eb1d70b269479
https://doi.org/10.1074/jbc.m304189200

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NF-κB and IκBα Are Found in the Mitochondria

Autor: Cindy L. Bristow, Albert S. Baldwin, Denis C. Guttridge, Jayne A. Keifer, Sophie Roy, Julie Y. Reuther, Patricia C. Cogswell, Donald W. Nicholson, David F. Kashatus

Publikováno v: Journal of Biological Chemistry. 278:2963-2968

The transcription factor NF-kappa B has been shown to be predominantly cytoplasmically localized in the absence of an inductive signal. Stimulation of cells with inflammatory cytokines such as tumor necrosis factor alpha or interleukin-1 induces the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cee6695a9fe854f1d4319fd4bfb66766
https://doi.org/10.1074/jbc.m209995200

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NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B

Autor: Patricia C, Cogswell, David F, Kashatus, Jayne A, Keifer, Denis C, Guttridge, Julie Y, Reuther, Cindy, Bristow, Sophie, Roy, Donald W, Nicholson, Albert S, Baldwin

Publikováno v: The Journal of biological chemistry. 278(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb08413948d8532441b509a66054baf2
https://pubmed.ncbi.nlm.nih.gov/12433922

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The p65/RelA subunit of NF-kappaB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor

Autor: Cun-Yu Wang, John K. Westwick, H. Shelton Earp, David F. Kashatus, Albert S. Baldwin, Roger J. Davis, Julie Y. Reuther-Madrid, Shaoqiong Chen, Xiong Li

Publikováno v: Molecular and cellular biology. 22(23)

Tumor necrosis factor (TNF) signaling through the TNF receptors involves the recruitment of key signaling factors, leading to the activation of both the transcription factor NF-kappaB and the stress-activated Jun kinase (JNK). In most cells, TNF sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af174ac6f745c25cfda3cf26c5886147
https://pubmed.ncbi.nlm.nih.gov/12417721

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Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38

Autor: Albert S. Baldwin, Julie Y. Reuther, Lee V. Madrid, Marty W. Mayo

The serine/threonine kinase Akt/PKB is a potent regulator of cell survival and has oncogenic transformation potential. Previously, it has been shown that Akt can activate the transcription factor NF-kappaB and that this functions to block apoptosis i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013769c672b1c1baf6afb7528562814f

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NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

Autor: Richard G. Pestell, Denis C. Guttridge, Julie Y. Reuther, Albert S. Baldwin, Chris Albanese

Accumulating evidence implicates the transcription factor NF-kappaB as a positive mediator of cell growth, but the molecular mechanism(s) involved in this process remains largely unknown. Here we use both a skeletal muscle differentiation model and n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fed783cd5f46aaf941adcbe34867369
https://europepmc.org/articles/PMC84428/

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Apoptosis promotes a caspase-induced amino-terminal truncation of IkappaBalpha that functions as a stable inhibitor of NF-kappaB

Autor: Albert S. Baldwin, Julie Y. Reuther

Publikováno v: The Journal of biological chemistry. 274(29)

Caspases are cell death cysteine proteases that are activated upon the induction of the apoptotic program and cleave target proteins in a sequence-specific manner to promote cell death. Recently, Barkett et al. (Barkett, M., Xue, D., Horvitz, H. R.,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33657abc8cd970c3a246aa27bee28144
https://pubmed.ncbi.nlm.nih.gov/10400699

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A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation

Autor: Albert S. Baldwin, David Cortez, Ann Marie Pendergast, Julie Y. Reuther, Gary W. Reuther

Publikováno v: Genesdevelopment. 12(7)

Bcr-Abl is a chimeric oncoprotein that is strongly implicated in acute lymphoblastic (ALL) and chronic myelogenous leukemias (CML). This deregulated tyrosine kinase selectively causes hematopoietic disorders resembling human leukemias in animal model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3726cb957f75c5c87c91f5b7382bfa83
https://pubmed.ncbi.nlm.nih.gov/9531535

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