Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Julie Workman"'
Autor:
M. Janusz Mezynski, Angela M. Farrelly, Mattia Cremona, Aoife Carr, Clare Morgan, Julie Workman, Paul Armstrong, Jennifer McAuley, Stephen Madden, Joanna Fay, Katherine M. Sheehan, Elaine W. Kay, Ciara Holohan, Yasir Elamin, Shereen Rafee, Patrick G. Morris, Oscar Breathnach, Liam Grogan, Bryan T. Hennessy, Sinead Toomey
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-16 (2021)
Abstract Background Aberrant PI3K signalling is implicated in trastuzumab resistance in HER2-positive gastric cancer (GC). The role of PI3K or MEK inhibitors in sensitising HER2-positive GCs to trastuzumab or in overcoming trastuzumab resistance is u
Externí odkaz:
https://doaj.org/article/d5312ba8bd22456eb68ea89c9e9a8189
Autor:
Paul Armstrong, Bryan T. Hennessy, Joanna Fay, Yasir Y. Elamin, Aoife Carr, Katherine M. Sheehan, M. Janusz Mezynski, Clare Morgan, Liam Grogan, Stephen F. Madden, Mattia Cremona, Elaine W. Kay, Jennifer McAuley, Ciara Holohan, Oscar S. Breathnach, Patrick G. Morris, Shereen Rafee, Julie Workman, Sinead Toomey, Angela M. Farrelly
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-16 (2021)
Journal of Translational Medicine
Journal of Translational Medicine
Background Aberrant PI3K signalling is implicated in trastuzumab resistance in HER2-positive gastric cancer (GC). The role of PI3K or MEK inhibitors in sensitising HER2-positive GCs to trastuzumab or in overcoming trastuzumab resistance is unclear. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d4b569521ef39bfe061a142aa53850
https://doaj.org/article/d5312ba8bd22456eb68ea89c9e9a8189
https://doaj.org/article/d5312ba8bd22456eb68ea89c9e9a8189
Autor:
Daniel J. Ryan, Sinead Toomey, Robert Smyth, Stephen F. Madden, Julie Workman, Robert Cummins, Katherine Sheehan, Joanna Fay, Jarushka Naidoo, Oscar S. Breathnach, Patrick G. Morris, Liam Grogan, Michael E. O'Brien, Imran Sulaiman, Bryan T. Hennessy, Ross K. Morgan
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 168
Small diagnostic tissue samples can be inadequate in testing an expanding list of validated oncogenic driver alterations and fail to reflect intratumour heterogeneity (ITGH) in lung cancer. Liquid biopsies are non-invasive and may better reflect ITGH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3bdde11032536306c359ccaa620d6de
https://pubmed.ncbi.nlm.nih.gov/35526313
https://pubmed.ncbi.nlm.nih.gov/35526313
Autor:
Sean P. Kennedy, Mattia Cremona, Aoife Carr, Razia Aslam, Stephen F. Madden, Bryan T. Hennessy, Angela M. Farrelly, Sinead Toomey, C.L. Lee, Julie Workman
Background: Studies have demonstrated the efficacy of Palbociclib (CDK 4/6 inhibitor), Gedatolisib (PI3K/mTOR dual inhibitor) and PD0325901 (MEK1/2 inhibitor) in colorectal cancer (CRC), however single agent therapeutics are often limited by resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bdddeca9bb8298b5bf0cf7523a424aa
https://doi.org/10.21203/rs.3.rs-647758/v1
https://doi.org/10.21203/rs.3.rs-647758/v1
Publikováno v:
Journal of Clinical Oncology. 38:179-179
179 Background: Combinative inhibitors with multiple actions to target downstream effectors are good strategy to reduce resistance occurrence. This is a preclinical study to evaluate efficacy of Palbociclib (P; CDK4/6 inhibitor) in combination with e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a24595de24c5e5ca571ad7256dcd1cd9
https://doi.org/10.1200/jco.2020.38.4_suppl.179
https://doi.org/10.1200/jco.2020.38.4_suppl.179
Autor:
David S. Janzen, Bruce DeBruhl, Zoë J. Wood, John Bellardo, Hugh Smith, Zachary N. J. Peterson, John Clements, Julie Workman, Michael Haungs
Publikováno v:
SIGCSE
Since 2010, the Cal Poly Computer Science Department has required computing majors to select from a variety of CS0 courses to start their academic year. The broad objective of the course is to attract and retain undergraduates that have no prior expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12332153159b403d3ba088f43c98e107
https://doi.org/10.1145/3159450.3159592
https://doi.org/10.1145/3159450.3159592
Autor:
M.J. Mezynski, Liam Grogan, S. Rafee, Yasir Y. Elamin, Sinead Toomey, Mattia Cremona, J. McAuley, C. Holohan, Patrick G. Morris, Julie Workman, Oscar S. Breathnach, Angela M. Farrelly, Bryan T. Hennessy, P. Armstrong, Joanna Fay, Elaine W. Kay
Publikováno v:
Annals of Oncology. 30:v310
Background HER2 is overexpressed in 10-25% of gastric cancers (GCs). The association of PI3K pathway activating mutations with HER2 overexpression, or the impact of aberrant PI3K pathway signalling on response to trastuzumab (Tr) in GC has not been d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc69a0e958d575a017604faddde28520
https://doi.org/10.1093/annonc/mdz247.133
https://doi.org/10.1093/annonc/mdz247.133
Autor:
Sherif El-Masry, S. Hummel, Brian P. O'Neill, C.L. Lee, Aoife Carr, A. Sartori, Julie Workman, D. Irwin, Oscar S. Breathnach, Angela M. Farrelly, S. Bradshaw, Bryan T. Hennessy, Sinead Toomey, Deborah A. McNamara, P. Armstrong, A.N.A.M. Rashed, Liam Grogan, Patrick G. Morris, L. O’Sullivan, Robert J. Smyth
Publikováno v:
Annals of Oncology. 29:viii184
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09321e48d89e39cd4f3c05946ce9cc77
https://doi.org/10.1093/annonc/mdy281.097
https://doi.org/10.1093/annonc/mdy281.097
Publikováno v:
53rd AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics and Materials Conference20th AIAA/ASME/AHS Adaptive Structures Conference14th AIAA.
*† ‡ § The Effects of Defects is important for the reliability of modern composite wind turbine blades. The DOE has sponsored a comprehensive study to characterize common manufacturing defects and establish damage growth and validation tools to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eac43a4c65b09bd2a85ab75e03d4aaae
https://doi.org/10.2514/6.2012-1421
https://doi.org/10.2514/6.2012-1421
Publikováno v:
53rd AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics and Materials Conference20th AIAA/ASME/AHS Adaptive Structures Conference14th AIAA.
The Effects of Defects in composites materials common to wind turbine blades is presented in this work. A comprehensive approach has been taken by the authors for the development of a wind turbine blade reliability infrastructure. The framework for a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b5d03288481102691b1fac86624f3e8
https://doi.org/10.2514/6.2012-1420
https://doi.org/10.2514/6.2012-1420