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Autor:
Julie Wilmowski, Hua Gao, Jana Polivkova, Dilinie P. Fernando, John R. Hadcock, Lucinda Thiede, Yue Chen, Angel Guzman-Perez, Paul Da Silva Jardine, Dennis O. Scott, Yingxin Zhang, Lucy Rogers, David Austen Perry, Denise Gautreau, Elena E. Beretta, Sophie Y. Lavergne, Catherine E. Trebino, Swick Andrew Gordon, Kimberly O. Cameron, Jeffrey T. Kohrt, Margaret Y. Chu-Moyer, Richard V. Trilles, Christopher F. Hoth, Sylvie Perez, Michael Raymond Makowski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2943-2947
New cholecystokinin-1 receptor (CCK1R) agonist 'triggers' were identified using iterative library synthesis. Structural activity relationship studies led to the discovery of compound 10e, a potent CCK1R agonist that demonstrated robust weight loss in