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Feasibility and preliminary safety and efficacy of first-in-human intraperitoneal delivery of MCY-M11, anti-human-mesothelin CAR mRNA transfected into peripheral blood mononuclear cells, for ovarian cancer and malignant peritoneal mesothelioma

Autor: Michael Kuo, Armin Ghobadi, Mira Pavelova, Julie Vanas, Charles Powell, Raffit Hassan, Cathy Wagner, Christina M. Annunziata, Premal H. Thaker, Eduardo J. Pennella, Claudio Dansky Ullmann

Publikováno v: Journal of Clinical Oncology. 38:3014-3014

3014 Background: MCY-M11 is a mesothelin-targeting chimeric antigen receptor (CAR) therapy made by a non-viral, mRNA-based platform, for rapid ( < 1 day) CAR manufacturing. We are conducting a phase I dose escalation trial in ovarian cancer and malig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cbe81225cc4a6b3b5aaa3b88a1b57e1
https://doi.org/10.1200/jco.2020.38.15_suppl.3014

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Abstract CT159: A phase 1 study of intraperitoneal MCY-M11 therapy for women with platinum resistant high grade serous adenocarcinoma of the ovary, primary peritoneum, or fallopian tube, or subjects with peritoneal mesothelioma with recurrence after prior chemotherapy

Autor: Robert Keefe, Premal H. Thaker, Julie Vanas, Christina M. Annunziata, Armin Ghobadi, Raffit Hassan, Mira Pavlova, David Weng, Irene Ekwede, Michael Kuo, Claudio Dansky Ullmann

Publikováno v: Cancer Research. 79:CT159-CT159

Background: Chimeric antigen receptor CAR T cell therapy for solid tumors has not yet achieved the success seen in hematologic malignancies. Many challenges remain, including the type of antigen being targeted, the risk for on-target off-tumor toxici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7c4f0c5dd7b8f068d697bab966f06ec
https://doi.org/10.1158/1538-7445.am2019-ct159

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Uridine triacetate as a lifesaving antidote for overdoses and severe early-onset 5-fluorouracil and capecitabine toxicities

Autor: Thomas H. Cartwright, Wasif M. Saif, Bassel F. El-Rayes, Reid W. von Borstel, Wen Wee Ma, Marwan Fakih, Julie Vanas, Michael K. Bamat, James Posey, Thomas King

Publikováno v: Journal of Clinical Oncology. 34:e21689-e21689

e21689Background: Uridine triacetate was approved by FDA in 2015 for adult and pediatric patients who exhibit early-onset, severe or life-threatening toxicities or who receive an overdose of 5-fluo...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ec887398d9bc08e815517cd3245c8f6
https://doi.org/10.1200/jco.2016.34.15_suppl.e21689

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