Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Julie V. Early"'
Autor:
Erik Hembre, Julie V. Early, Joshua Odingo, Catherine Shelton, Olena Anoshchenko, Junitta Guzman, Lindsay Flint, Devon Dennison, Matthew B. McNeil, Aaron Korkegian, Yulia Ovechkina, Paul Ornstein, Thierry Masquelin, Philip A. Hipskind, Tanya Parish
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The identification and development of new anti-tubercular agents are a priority research area. We identified the trifluoromethyl pyrimidinone series of compounds in a whole-cell screen against Mycobacterium tuberculosis. Fifteen primary hits had mini
Externí odkaz:
https://doaj.org/article/e41bd994abd04c9a99524a1146aad2db
Autor:
Joshua Odingo, Mai A. Bailey, Megan Files, Julie V. Early, Torey Alling, Devon Dennison, Julie Bowman, Suryakanta Dalai, Naresh Kumar, Jeffrey Cramer, Thierry Masquelin, Philip A. Hipskind, Tanya Parish
Publikováno v:
ACS Omega, Vol 2, Iss 9, Pp 5873-5890 (2017)
Externí odkaz:
https://doaj.org/article/17e6ec56a92e416e8259d03c4b34d236
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80881efd33daa3873e493991e79e39ac
https://doi.org/10.1128/aac.00962-22
https://doi.org/10.1128/aac.00962-22
Autor:
Tanya Parish, Lindsay Flint, Anuradha Kumar, Lisa M. Massoudi, Paul Scullion, Gregory T. Robertson, Shilah A. Bonnett, Simon Green, Nicola Caldwell, Jennifer Riley, Gail M. Freiberg, Philip Arthur Hipskind, Michael Mathieson, Thierry Masquelin, Laste Stojanovski, Curtis A. Engelhart, Margaret Huggett, Dinakaran Murugesan, Abraham Lopez Moure, Fabio Zuccotto, Julie V. Early, Ola Epemolu, Paul G. Wyatt, Dale J. Kempf, Kevin D. Read, Susan Davis, Laura A. T. Cleghorn, James Johnson, Steven Mullen, Malcolm Taylor, Anne J. Lenaerts, Penelope A. Turner, Peter C. Ray, Joshua Odingo, Dirk Schnappinger, Aaron Korkegian, Douglas Joerss
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)
ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)
With the emergence of multi-drug-resistant strains of Mycobacterium tuberculosis, there is a pressing need for new oral drugs with novel mechanisms of action. A number of scaffolds with potent anti-tubercular in vitro activity have been identified fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372e1778402b9efb43904bc638481606
http://europepmc.org/articles/PMC7841955
http://europepmc.org/articles/PMC7841955
Publikováno v:
Antimicrobial Agents and Chemotherapy
Antimicrob Agents Chemother
Antimicrob Agents Chemother
Tuberculosis, caused by Mycobacterium tuberculosis, is an urgent global health problem requiring new drugs, new drug targets, and an increased understanding of antibiotic resistance. We have determined the mode of resistance to be a series of arylami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1c6b14a17cac1638bea7d3ef611808
https://doi.org/10.1128/aac.02334-20
https://doi.org/10.1128/aac.02334-20
There is an urgent need for new anti-tubercular agents which can lead to a shortened treatment time by targeting persistent or non-replicating bacilli. In order to assess compound activity against non-replicatingMycobacterium tuberculosis, we develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2c2452a219ed403b6cadf7e4f38118
https://doi.org/10.1101/578195
https://doi.org/10.1101/578195
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 10, p e0222970 (2019)
PLoS ONE, Vol 14, Iss 10, p e0222970 (2019)
There is an urgent need for new anti-tubercular agents which can lead to a shortened treatment time by targeting persistent or non-replicating bacilli. In order to assess compound activity against non-replicating Mycobacterium tuberculosis, we develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d75aabdcf9efb688ac39028f770d87
https://pubmed.ncbi.nlm.nih.gov/31589621
https://pubmed.ncbi.nlm.nih.gov/31589621
Autor:
Joshua O, Odingo, Julie V, Early, Jake, Smith, James, Johnson, Mai A, Bailey, Megan, Files, Junitta, Guzman, Juliane, Ollinger, Aaron, Korkegian, Anuradha, Kumar, Yulia, Ovechkina, Tanya, Parish
Publikováno v:
Drug Development Research
There is an urgent need for new treatments effective against Mycobacterium tuberculosis, the causative agent of tuberculosis. The 8‐hydroxyquinoline series is a privileged scaffold with anticancer, antifungal, and antibacterial activities. We condu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f94ff83db2bcd1fa8d50f76a41dd9e9
https://pubmed.ncbi.nlm.nih.gov/30893501
https://pubmed.ncbi.nlm.nih.gov/30893501
Autor:
Mai A. Bailey, Maria Angeles Martinez-Grau, Yulia Ovechkina, Allen Casey, Tanya Parish, Isabel C. Gonzalez Valcarcel, Torey Alling, Juliane Ollinger, Michal Vieth, Megan Files, Julie V. Early
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:3608-3616
Mycobacterium tuberculosis is a global pathogen of huge importance which can adapt to several host niche environments in which carbon source availability is likely to vary. We developed and ran a phenotypic screen using butyrate as the sole carbon so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b15ab5c46fbfc7b9a62b9bcc568fc4
https://doi.org/10.1128/aac.02896-15
https://doi.org/10.1128/aac.02896-15
Autor:
Thierry Masquelin, Julie V. Early, Garrett C. Moraski, Philip Arthur Hipskind, Marvin J. Miller, Tanya Parish, Heather Wescott, Torey Alling, Theresa O’Malley, Anuradha Kumar
Publikováno v:
Antimicrobial Agents and Chemotherapy
The imidazopyridines are a promising new class of antitubercular agents with potent activity in vitro and in vivo . We isolated mutants of Mycobacterium tuberculosis resistant to a representative imidazopyridine; the mutants had large shifts (>20-fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3747d67a44f08de50e84d89403f8a0f0
http://europepmc.org/articles/PMC5971599
http://europepmc.org/articles/PMC5971599