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Purification of mRNA Encoding Chimeric Antigen Receptor Is Critical for Generation of a Robust T-Cell Response

Autor: Phillip B. Storm, Jessica Perazzelli, Angela J. Waanders, Ted J. Hofmann, Adam C. Resnick, David M. Barrett, Stephan A. Grupp, Julie Storm, Payal Jain, Norbert Pardi, Drew Weissman, Namrata Choudhari, Katalin Karikó, Jessica B. Foster

Publikováno v: Human Gene Therapy

T cells made with messenger RNA (mRNA) encoding chimeric antigen receptor (CAR) offer a safe alternative to those transduced with viral CARs by mitigating the side effects of constitutively active T cells. Previous studies have shown that mRNA CAR T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc1b02254351ad49a97b7ba5082ed71
http://europepmc.org/articles/PMC6383579

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Haemophilus influenzae LicB contributes to lung damage in an aged mice co-infection model

Autor: Jessica Bondy, Timothy McAuliffe, Graham Durning, Xin Fan, Sofya Osharovich, Julie Storm

Publikováno v: Microbial Pathogenesis. 90:1-6

Phosphorylcholine (ChoP) decoration of lipopolysaccharides is an important virulence strategy adopted by Haemophilus influenzae to establish a niche on the mucosal surface and to promote adherence to the host cells. The incorporation of ChoP on the L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e3073680ba7d73f929e75cdd329480
https://doi.org/10.1016/j.micpath.2015.10.010

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Abstract 1631: T cell dysfunction in pediatric cancer patients at diagnosis and after chemotherapy can limit chimeric antigen receptor potential

Autor: David M. Barrett, Julie Storm, Rajat K. Das

Publikováno v: Cancer Research. 78:1631-1631

Cellular therapy using engineered T cells has demonstrated clinical efficacy in the treatment of hematologic malignancies. Many patients, however, have T cells that result in a poor clinical product that either fails manufacture or does not prolifera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c098667225749acca4bcad7380520d3
https://doi.org/10.1158/1538-7445.am2018-1631

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Abstract 2622: T cell content of lymphatic fluid in pediatric patients is biased towards naïve and early memory cells: Implications for immunotherapy

Autor: Yoav Dori, Jessica Perazzelli, David M. Barrett, Julie Storm

Publikováno v: Cancer Research. 78:2622-2622

Lymphatic fluid originating from tissue and organs drains back into the venous system usually near the innominate vein on the left side. T lymphocytes make up a large majority of the cells in lymphatic fluid, but little is known about their functiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19198f970faa9c0238e48c7d8ceecff4
https://doi.org/10.1158/1538-7445.am2018-2622

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Pigs in pain - porcine behavioural responses towards mechanical nociceptive stimulation directed at the hind legs

Autor: Herskin, Mette S, Rasmussen, Julie Storm

Publikováno v: Herskin, M S & Rasmussen, J S 2010, ' Pigs in pain-porcine behavioural responses towards mechanical nociceptive stimulation directed at the hind legs ', Oslo, Norway, 08/04/2010-10/04/2010, .
Herskin, M S & Rasmussen, J S 2010, ' Pigs in pain-porcine behavioural responses towards mechanical nociceptive stimulation directed at the hind legs ', Scandinavian Journal of Pain, no. 3, pp. 59-60 .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::09bbc04d6d84699d3a126c777c0fb782
https://pure.au.dk/portal/da/publications/pigs-in-pain--porcine-behavioural-responses-towards-mechanical-nociceptive-stimulation-directed-at-the-hind-legs(cc7619f0-63fa-11df-8b17-000ea68e967b).html

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