Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Julie Secombe"'
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract Background Drosophila melanogaster is excellent animal model for understanding the molecular basis of human neurological and motor disorders. The experimental conditions and chamber design varied between studies. Moreover, most previously es
Externí odkaz:
https://doaj.org/article/305f1e96845b49d68ea591ac68437326
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract Background KDM5 family proteins are multi-domain regulators of transcription that when dysregulated contribute to cancer and intellectual disability. KDM5 proteins can regulate transcription through their histone demethylase activity in addi
Externí odkaz:
https://doaj.org/article/58e77dd544d441039134b2ff7d072bf7
Publikováno v:
eLife, Vol 10 (2021)
Mutations in the lysine demethylase 5 (KDM5) family of transcriptional regulators are associated with intellectual disability, yet little is known regarding their spatiotemporal requirements or neurodevelopmental contributions. Utilizing the mushroom
Externí odkaz:
https://doaj.org/article/a04043ac6cdd40deac4e64dbb57e7db6
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2359-2369 (2018)
Summary: Mutations in KDM5 family histone demethylases cause intellectual disability in humans. However, the molecular mechanisms linking KDM5-regulated transcription and cognition remain unknown. Here, we establish Drosophila as a model to understan
Externí odkaz:
https://doaj.org/article/b187904b04464079aec529b3a1b5186a
Autor:
Paulo Navarro-Costa, Alicia McCarthy, Pedro Prudêncio, Christina Greer, Leonardo G. Guilgur, Jörg D. Becker, Julie Secombe, Prashanth Rangan, Rui G. Martinho
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Meiotically arrested oocytes retain transcriptional ability despite chromosome condensation. Here, the authors show that Drosophilaoocytes regulate meiotic transcription and chromatin remodelling through the programming, in early oogenesis, of an ext
Externí odkaz:
https://doaj.org/article/da483c52a0874914bacfe613e1de3885
Autor:
Xingyin Liu, Julie Secombe
Publikováno v:
Cell Reports, Vol 13, Iss 10, Pp 2219-2231 (2015)
KDM5 family proteins are critically important transcriptional regulators whose physiological functions in the context of a whole animal remain largely unknown. Using genome-wide gene expression and binding analyses in Drosophila adults, we demonstrat
Externí odkaz:
https://doaj.org/article/1e077a1616ed45e492c864ba6747e41c
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004676 (2014)
Increased cellular levels of oxidative stress are implicated in a large number of human diseases. Here we describe the transcription co-factor KDM5 (also known as Lid) as a new critical regulator of cellular redox state. Moreover, this occurs through
Externí odkaz:
https://doaj.org/article/96e2a2922e984d4293959f4026583426
Autor:
Christina Greer, Moonsook Lee, Maaike Westerhof, Brandon Milholland, Rebecca Spokony, Jan Vijg, Julie Secombe
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74641 (2013)
The Myc family of transcription factors are key regulators of cell growth and proliferation that are dysregulated in a large number of human cancers. When overexpressed, Myc family proteins also cause genomic instability, a hallmark of both transform
Externí odkaz:
https://doaj.org/article/04a4cb55900e4857956d095b7e355c44
Publikováno v:
PLoS Genetics, Vol 6, Iss 11, p e1001221 (2010)
Drosophila Little imaginal discs (Lid) is a recently described member of the JmjC domain class of histone demethylases that specifically targets trimethylated histone H3 lysine 4 (H3K4me3). To understand its biological function, we have utilized a se
Externí odkaz:
https://doaj.org/article/fad734f2e6884082b166982119466d53
The precise coordination of gene expression is critical for developmental programs, and histone modifying proteins play important, conserved roles in fine-tuning transcription for these processes. One such family of proteins are KDM5 enzymes that int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a38266c27f48073b2ff6c336a96ad50
https://doi.org/10.1101/2023.05.23.541787
https://doi.org/10.1101/2023.05.23.541787
