Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Julie Saint-Paul"'
Antibody-mediated neutralization of galectin-3 as a strategy for the treatment of systemic sclerosis
Autor:
Céline Ortega-Ferreira, Perrine Soret, Gautier Robin, Silvia Speca, Sandra Hubert, Marianne Le Gall, Emiko Desvaux, Manel Jendoubi, Julie Saint-Paul, Loubna Chadli, Agnès Chomel, Sylvie Berger, Emmanuel Nony, Béatrice Neau, Benjamin Fould, Anne Licznar, Franck Levasseur, Thomas Guerrier, Sahar Elouej, Sophie Courtade-Gaïani, Nicolas Provost, The Quyen Nguyen, Julien Verdier, David Launay, Frédéric De Ceuninck
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Systemic sclerosis (SSc) is an autoimmune, inflammatory and fibrotic disease with limited treatment options. Developing new therapies is therefore crucial to address patient needs. To this end, we focused on galectin-3 (Gal-3), a lectin know
Externí odkaz:
https://doaj.org/article/b4ac4a8d08c9436badd6ef4d718b8e03
Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy
Autor:
Ieva Vasiliauskaité-Brooks, Robert D. Healey, Pascal Rochaix, Julie Saint-Paul, Rémy Sounier, Claire Grison, Thierry Waltrich-Augusto, Mathieu Fortier, François Hoh, Essa M. Saied, Christoph Arenz, Shibom Basu, Cédric Leyrat, Sébastien Granier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Alkaline ceramidases (ACERs) are a class of poorly understood transmembrane enzymes controlling the homeostasis of ceramides. Here authors solve the Xray structure of human ACER3 and uncover a Ca2+ binding site providing an explanation for the known
Externí odkaz:
https://doaj.org/article/9944c8e0584f421dad2c7d0bf7a0b051
Autor:
Julien Bous, Aurélien Fouillen, Hélène Orcel, Stefano Trapani, Xiaojing Cong, Simon Fontanel, Julie Saint-Paul, Joséphine Lai-Kee-Him, Serge Urbach, Nathalie Sibille, Rémy Sounier, Sébastien Granier, Bernard Mouillac, Patrick Bron
Publikováno v:
Science Advances
Science Advances, 2022, 8 (35), pp.eabo7761. ⟨10.1126/sciadv.abo7761⟩
Science Advances, 2022, 8 (35), pp.eabo7761. ⟨10.1126/sciadv.abo7761⟩
Arrestins interact with G protein-coupled receptors (GPCRs) to stop G protein activation and to initiate key signaling pathways. Recent structural studies shed light on the molecular mechanisms involved in GPCR-arrestin coupling, but whether this pro
Autor:
Thorsten Hornemann, Cedric Leyrat, Christoph Arenz, Shibom Basu, Damien Maurel, Marion Drapeau, Julie Saint Paul, Essa M. Saied, Gergely Karsai, Elise Del Nero, Sébastien Granier, Xiaojing Cong, Ludovic Gabellier, Guillaume Bossis, Jérôme Golebiowski, Cherine Bechara, Robert D. Healey, Sylvain Jeannot, Simon Fontanel
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2021, ⟨10.1002/anie.202109967⟩
Angewandte Chemie International Edition, 2022, 61 (2), pp.e202109967. ⟨10.1002/anie.202109967⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2022, 61 (2), pp.e202109967. ⟨10.1002/anie.202109967⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2021, ⟨10.1002/anie.202109967⟩
Angewandte Chemie International Edition, 2022, 61 (2), pp.e202109967. ⟨10.1002/anie.202109967⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2022, 61 (2), pp.e202109967. ⟨10.1002/anie.202109967⟩
International audience; Sphingolipid metabolism is tightly controlled by enzymes to regulate essential processes in human physiology. The central metabolite is ceramide, a pro-apoptotic lipid catabolized by ceramidase enzymes to produce pro-prolifera
Autor:
Sylvain Jeannot, Gergely Karsai, Essa M. Saied, Damien Maurel, Julie Saint-Paul, Xiaojing Cong, Marion Drapeau, Christoph Arenz, Simon Fontanel, Sébastien Granier, Cedric Leyrat, Thorsten Hornemann, Guillaume Bossis, Shibom Basu, Ludovic Gabellier, Robert D. Healey, Elise Del Nero, Cherine Bechara
Sphingolipid metabolism is tightly controlled by enzymes to regulate essential processes such as energy utilisation and cell proliferation. The central metabolite is ceramide, a pro-apoptotic lipid catabolized by ceramidase enzymes to ultimately prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88524cf7591ed1713ea9bbf20c94c917
https://doi.org/10.1101/2021.06.15.448479
https://doi.org/10.1101/2021.06.15.448479
Autor:
Patrick Bron, Stefano Trapani, Hélène Orcel, Julien Bous, Nicolas Floquet, Remy Sounier, Cedric Leyrat, Aurelie Ancelin, Julie Saint-Paul, Sébastien Granier, Gérald Gaibelet, Joséphine Lai-Kee-Him, Hélène Déméné, Bernard Mouillac, Maxime Louet
Publikováno v:
Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (21), pp.eabg5628. ⟨10.1126/sciadv.abg5628⟩
Science Advances, 2021, 7 (21), pp.eabg5628. ⟨10.1126/sciadv.abg5628⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (21), pp.eabg5628. ⟨10.1126/sciadv.abg5628⟩
Science Advances, 2021, 7 (21), pp.eabg5628. ⟨10.1126/sciadv.abg5628⟩
Structures of the AVP-V2R-Gs protein complex provide molecular insights into the function of this clinically relevant target.
The antidiuretic hormone arginine-vasopressin (AVP) forms a signaling complex with the V2 receptor (V2R) and the Gs pro
The antidiuretic hormone arginine-vasopressin (AVP) forms a signaling complex with the V2 receptor (V2R) and the Gs pro
Autor:
Damien Maurel, Hélène Déméné, Remy Sounier, Jérôme Golebiowski, Xiaojing Cong, Julie Saint-Paul, Fanny Peysson, Ieva Vasiliauskaité-Brooks, Sébastien Granier, Joanna Hagelberger
SUMMARYGPCR functional selectivity has opened new opportunities for the design of safer drugs. Ligands orchestrate GPCR signaling cascades by modulating the receptor conformational landscape. Our study provides insights into the dynamic mechanism ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2c2ea04e68f0231882d24661b15fd06
https://doi.org/10.1101/2021.03.22.436421
https://doi.org/10.1101/2021.03.22.436421
Autor:
Julien Bous, Aurelie Ancelin, Nicolas Floquet, Hélène Orcel, Joséphine Lai-Kee-Him, Stefano Trapani, Julie Saint-Paul, Hélène Déméné, Sébastien Granier, Patrick Bron, Maxime Louet, Remy Sounier, Gérald Gaibelet, Bernard Mouillac, Cedric Leyrat
Arginine-vasopressin (AVP) is a neurohypophysial peptide known as the antidiuretic hormone. It forms an active signalling complex with the V2 receptor (V2R) and the Gs protein, promoting a cAMP/PKA-dependent aquaporin insertion in apical membranes of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a5993c6f47ec20e9d586f9877003a8
https://doi.org/10.1101/2020.12.22.424028
https://doi.org/10.1101/2020.12.22.424028
Autor:
Damien Maurel, Xiaojing Cong, Joanna Hagelberger, Fanny Peysson, Sébastien Granier, Hélène Déméné, Jérôme Golebiowski, Remy Sounier, Julie Saint-Paul, Ieva Vasiliauskaité-Brooks
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, In press, ⟨10.1016/j.molcel.2021.07.033⟩
Molecular Cell, Elsevier, In press, 81 (20), pp.4165-4175.e6. ⟨10.1016/j.molcel.2021.07.033⟩
Molecular Cell, Elsevier, In press, ⟨10.1016/j.molcel.2021.07.033⟩
Molecular Cell, Elsevier, In press, 81 (20), pp.4165-4175.e6. ⟨10.1016/j.molcel.2021.07.033⟩
International audience; GPCR functional selectivity opens new opportunities for the design of safer drugs. Ligands orchestrate GPCR signaling cascades by modulating the receptor conformational landscape. Our study provides insights into the dynamic m