Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Julie S. Yuan"'
Autor:
Jean C.Y. Wang, John E. Dick, Cynthia Guidos, Donna E. Hogge, Mark D. Minden, Yulia Merkulova, Sofie Perdu, Stevan Lauriault, Goce Bogdanoski, James A. Kennedy, Gitte Gerhard, Jessica McLeod, Andreea C. Popescu, Nathan Mbong, Amanda Mitchell, Yan Xing, Julie S. Yuan, Weihsu C. Chen
Many promising new cancer drugs proceed through preclinical testing and early-phase trials only to fail in late-stage clinical testing. Thus, improved models that better predict survival outcomes and enable the development of biomarkers are needed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace6912470dc065ae62d296a0ae6d9ee
https://doi.org/10.1158/0008-5472.c.6507614
https://doi.org/10.1158/0008-5472.c.6507614
Autor:
Jean C.Y. Wang, John E. Dick, Cynthia Guidos, Donna E. Hogge, Mark D. Minden, Yulia Merkulova, Sofie Perdu, Stevan Lauriault, Goce Bogdanoski, James A. Kennedy, Gitte Gerhard, Jessica McLeod, Andreea C. Popescu, Nathan Mbong, Amanda Mitchell, Yan Xing, Julie S. Yuan, Weihsu C. Chen
Supplemental Methods Supplemental Table 1 Supplemental Figures 1-6 1. Pretreatment with cytarabine potentiates the effects of FED in AML xenografts. Supplemental Figure 2. PF cytometry analysis of AML samples. Supplemental Figure 3. Immunophenotypic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0407829e704b03b162569a3c7be4cf1c
https://doi.org/10.1158/0008-5472.22408769.v1
https://doi.org/10.1158/0008-5472.22408769.v1
Autor:
Marina E Tourlakis, Siyi Zhang, Heather L Ball, Rikesh Gandhi, Hongrui Liu, Jian Zhong, Julie S Yuan, Cynthia J Guidos, Peter R Durie, Johanna M Rommens
Publikováno v:
PLoS Genetics, Vol 11, Iss 6, p e1005288 (2015)
Genetic models of ribosome dysfunction show selective organ failure, highlighting a gap in our understanding of cell-type specific responses to translation insufficiency. Translation defects underlie a growing list of inherited and acquired cancer-pr
Externí odkaz:
https://doaj.org/article/856671ca104e4135a514d8fa8c538e54
Autor:
Stephen Chang, Goce Bogdanoski, Amine Boudil, Irina Matei, Michael S. Krangel, Shaheena Bashir, Bertrand Montpellier, Julie S. Yuan, Han-Yu Shih, Veronique Voisin, Cynthia J. Guidos, Paul E. Kowalski, Gary D. Bader
Publikováno v:
Nature immunology
Signaling via the pre-T cell antigen receptor (pre-TCR) and the receptor Notch1 induces transient self-renewal (β-selection) of TCRβ(+) CD4(-)CD8(-) double-negative stage 3 (DN3) and DN4 progenitor cells that differentiate into CD4(+)CD8(+) double-
Autor:
Mark D. Minden, Sofie Perdu, Amanda Mitchell, Donna E. Hogge, Yulia Merkulova, Nathan Mbong, John E. Dick, Stevan Lauriault, Yan Xing, Cynthia J. Guidos, Goce Bogdanoski, Gitte Gerhard, Jessica McLeod, Weihsu C. Chen, Jean C.Y. Wang, Julie S. Yuan, James A. Kennedy, Andreea C. Popescu
Publikováno v:
Cancer research. 76(5)
Many promising new cancer drugs proceed through preclinical testing and early-phase trials only to fail in late-stage clinical testing. Thus, improved models that better predict survival outcomes and enable the development of biomarkers are needed to
Publikováno v:
Annual Review of Immunology. 28:343-365
Mammalian genomes encode up to four Notch receptors (Notch1–4) and five Notch ligands of the DSL (Delta/Serrate/Lag-2) family, and Notch signaling controls a wide spectrum of developmental processes. Intrathymic Notch1 signaling is essential for se
Autor:
Rikesh Gandhi, Julie S. Yuan, Siyi Zhang, Cynthia J. Guidos, Jian Zhong, Peter R. Durie, Heather L. Ball, Hongrui Liu, Marina E. Tourlakis, Johanna M. Rommens
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 11, Iss 6, p e1005288 (2015)
PLoS Genetics, Vol 11, Iss 6, p e1005288 (2015)
Genetic models of ribosome dysfunction show selective organ failure, highlighting a gap in our understanding of cell-type specific responses to translation insufficiency. Translation defects underlie a growing list of inherited and acquired cancer-pr
Publikováno v:
Nature Immunology. 7:634-643
Notch1 activation regulates T lineage commitment and early T cell development. Fringe glycosyltransferases alter the sensitivity of Notch receptors to Delta-like versus Jagged Notch ligands, but their functions in T lymphopoiesis have not been define
Publikováno v:
Nature Immunology. 6:671-679
Signaling through the transmembrane Notch1 receptor directs thymus-seeding progenitors (TSPs) to suppress their B cell potential and 'choose' the T cell fate. Present paradigms suggest that TSPs are contained in the multipotent early T lineage precur
Publikováno v:
Clinical Genetics. 64:461-472
Notch receptors and ligands were first identified in flies and worms, where they were shown to regulate cell proliferation, cell differentiation, and, in particular, binary cell fate decisions in a variety of developmental contexts. The first mammali