Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Julie S. Schmøkel"'
Autor:
Matthias Kuhlmann, Jonas B.R. Hamming, Anders Voldum, Georgia Tsakiridou, Maja T. Larsen, Julie S. Schmøkel, Emil Sohn, Konrad Bienk, David Schaffert, Esben S. Sørensen, Jesper Wengel, Daniel M. Dupont, Kenneth A. Howard
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 284-293 (2017)
The long blood circulatory property of human serum albumin, due to engagement with the cellular recycling neonatal Fc receptor (FcRn), is an attractive drug half-life extension enabling technology. This work describes a novel site-specific albumin do
Externí odkaz:
https://doaj.org/article/51d4e0deff5046be96587b3e4baa4f58
Autor:
Kenneth A. Howard, Anders Voldum, Esben S. Sørensen, Julie S. Schmøkel, Jesper Wengel, Georgia Tsakiridou, Matthias Kuhlmann, Jason Cameron
Publikováno v:
Schmøkel, J, Voldum, A, Tsakiridou, G, Kuhlmann, M, Cameron, J, Sørensen, E S, Wengel, J & Howard, K A 2017, ' Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding ', Nanotechnology, vol. 28, no. 20, 204004 . https://doi.org/10.1088/1361-6528/aa6a9b
Schmøkel, J, Voldum, A, Tsakiridou, G, Kuhlmann, M, Cameron, J, Sørensen, E S, Wengel, J & Howard, K 2017, ' Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding ', Nanotechnology, vol. 28, 204004 . https://doi.org/10.1088/1361-6528/aa6a9b
Schmøkel, J, Voldum, A, Tsakiridou, G, Kuhlmann, M, Cameron, J, Sørensen, E S, Wengel, J & Howard, K 2017, ' Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding ', Nanotechnology, vol. 28, 204004 . https://doi.org/10.1088/1361-6528/aa6a9b
Aptamers are an attractive molecular medicine that offers high target specificity. Nucleic acid-based aptamers, however, are prone to nuclease degradation and rapid renal excretion that require blood circulatory half-life extension enabling technolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a92bfd8736f8e692d7dbec2e3b5960
https://pubmed.ncbi.nlm.nih.gov/28362634
https://pubmed.ncbi.nlm.nih.gov/28362634