Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Julie Rothacker"'
Autor:
Teruhiko Sato, Marc G. Achen, Julie Rothacker, Natalia Davydova, Edouard C. Nice, Karri Paavonen, Tara Karnezis, Sally Roufail, You-Fang Zhang, Nicole C. Harris, Sophie Paquet-Fifield, Steven A. Stacker
Publikováno v:
Journal of Biological Chemistry. 288:8176-8186
VEGF-D is an angiogenic and lymphangiogenic glycoprotein that can be proteolytically processed generating various forms differing in subunit composition due to the presence or absence of N- and C-terminal propeptides. These propeptides flank the cent
Autor:
Colin W. Ward, Antony W. Burgess, Edouard C. Nice, John D. Bentley, Timothy E. Adams, Julie Rothacker, Terrance Grant Johns, Jacqueline F. Donoghue, Mathias Hafner, George O. Lovrecz, Eva J. Koziolek, Olan Dolezal
Publikováno v:
Growth Factors. 30:310-319
Ligand-mediated activation of ErbB3 and ErbB4 is implicated in the pathogenesis of several human malignancies including cancer of the ovary and melanoma. We have used the broad ErbB ligand specificity of ErbB4 to assemble and express an ErbB4 fusion
Autor:
Christine Henderson, Edouard C. Nice, Andrew H. A. Clayton, Michael F. Bailey, Noga Kozer, Anthony W Burgess, Julie Rothacker
Publikováno v:
Biochemistry. 49:7459-7466
X-ray structural studies revealed two conformations of the epidermal growth factor receptor (EGFR) ectodomain (ECD): a compact, tethered conformation in the absence of EGF and an untethered or extended conformation in the presence of EGF. An EGFR-ECD
Publikováno v:
Journal of Chromatography A. 1217:3330-3340
Tumor related products shed into the feces offer a potential source of biomarkers for the detection of colorectal cancer (CRC). Using SDS-PAGE followed by nanoflow reversed-phased LC-MS/MS to analyse fecal samples from Apc(Min/+) mice (that develop s
Autor:
Webster K. Cavenee, Dane Wittrup, Ginger Chao, Anthony W Burgess, Gerd Ritter, Andrew M. Scott, Timothy E. Adams, Mezhen Lou, Bruno Catimel, Elisabeth Stockert, Thomas P. J. Garrett, Peter A. Hoyne, Rodney B. Luwor, Shenggen Yao, Francesca Walker, Edouard C. Nice, Lloyd J. Old, Jennifer R. Cochran, Julie Rothacker, Suzanne G Orchard, Trevor Huyton, W. Douglas Fairlie, Glenn A Cartwright, Andrew H. A. Clayton, Cindy S. Luo, Yibin Xu, Terrance Grant Johns, Hui K Gan
Publikováno v:
Proceedings of the National Academy of Sciences. 106:5082-5087
Epidermal Growth Factor Receptor (EGFR) is involved in stimulating the growth of many human tumors, but the success of therapeutic agents has been limited in part by interference from the EGFR on normal tissues. Previously, we reported an antibody (m
Autor:
Timothy E. Adams, Eva J. Koziolek, Peter H. Hoyne, John D. Bentley, Louis Lu, George Lovrecz, Colin W. Ward, F. T. Lee, Andrew M. Scott, Andrew D. Nash, Julie Rothacker, Edouard C. Nice, Antony W. Burgess, Terrance G. Johns
Publikováno v:
Growth Factors. 27:141-154
A number of therapeutic strategies including small molecule tyrosine kinase inhibitors and monoclonal antibodies have been developed to target the epidermal growth factor receptor (EGFR) signalling axis for the treatment of cancer. To date, the focus
Autor:
Edouard C. Nice, Emma E. Lees, Paul Mulvaney, Tich-Lam Nguyen, Menachem J. Gunzburg, Geoffrey J. Howlett, Julie Rothacker, Andrew H. A. Clayton
Publikováno v:
Nano Letters. 8:2883-2890
Analytical ultracentrifugation (AUC) was used to characterize the size distribution and surface chemistry of quantum dots (QDs). AUC was found to be highly sensitive to nanocrystal size, resolving nanocrystal sizes that differ by a single lattice pla
Publikováno v:
Journal of Chromatography A. 1168:190-210
The routine detection of low abundance components in complex samples for detailed proteomics analysis continues to be a challenge. Whilst the potential of multidimensional chromatographic fractionation for this purpose has been proposed for some year
Autor:
Julie Rothacker, Kenneth W. Harder, Edouard C. Nice, Tara Karnezis, Bradley McColl, Margaret L. Hibbs, Steven A. Stacker, Peter Rogers, Karri Paavonen, Marc G. Achen, Natalia Davydova, Kari Alitalo, Sally Roufail, Nicole C. Harris
Publikováno v:
The FASEB Journal. 21:1088-1098
Vascular endothelial growth factor (VEGF)-D is a secreted glycoprotein that induces angiogenesis and lymphangiogenesis. It consists of a central domain, containing binding sites for VEGF receptor-2 (VEGFR-2) and VEGFR-3, and N- and C-terminal propept
Autor:
Anthony W Burgess, A Clippingdale, Jenny Catimel, Julie Rothacker, Bruno Catimel, Lisa M. Connolly, Janine Ross, Maree C. Faux, Edouard C. Nice
Publikováno v:
Journal of Proteome Research. 4:1646-1656
A biosensor-based micro-affinity purification method to recover protein binding partners and their complexes for down stream proteomics analysis has been developed using the BIAcore 3000 fitted with a prototype Surface Prep Unit (SPU). The recombinan