Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Julie Rayes"'
Autor:
Jasmeet S. Reyat, Alessandro di Maio, Beata Grygielska, Jeremy Pike, Samuel Kemble, Antonio Rodriguez-Romero, Christina Simoglou Karali, Adam P. Croft, Bethan Psaila, Filipa Simões, Julie Rayes, Abdullah O. Khan
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
IntroductionRecent advances in human cardiac 3D approaches have yielded progressively more complex and physiologically relevant culture systems. However, their application in the study of complex pathological processes, such as inflammation and fibro
Externí odkaz:
https://doaj.org/article/3399289f4d04440a98842fe8c911f425
Autor:
Joshua H. Bourne, Joana Campos, Sophie J. Hopkin, Katharine Whitworth, James Palis, Yotis A. Senis, Julie Rayes, Asif J. Iqbal, Alexander Brill
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome has been described in both immune cells and platelets, but its role in the megakaryocyte (MK) lineage remains elusive.ObjectiveThe aim of this study was to explore t
Externí odkaz:
https://doaj.org/article/f12cd561058a4428b36a02a3bad37820
Autor:
Olga Krysko, Joshua H. Bourne, Elena Kondakova, Elena A. Galova, Katharine Whitworth, Maddy L. Newby, Claus Bachert, Harriet Hill, Max Crispin, Zania Stamataki, Adam F. Cunningham, Matthew Pugh, Abdullah O. Khan, Julie Rayes, Maria Vedunova, Dmitri V. Krysko, Alexander Brill
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundThe systemic inflammatory response post-SARS-CoV-2 infection increases pro-inflammatory cytokine production, multi-organ damage, and mortality rates. Mast cells (MC) modulate thrombo-inflammatory disease progression (e.g., deep vein thrombo
Externí odkaz:
https://doaj.org/article/79b67959ef144c44ab258fd04a23bccb
Autor:
Rachel E. Lamerton, Edith Marcial-Juarez, Sian E. Faustini, Marisol Perez-Toledo, Margaret Goodall, Siân E. Jossi, Maddy L. Newby, Iain Chapple, Thomas Dietrich, Tonny Veenith, Adrian M. Shields, Lorraine Harper, Ian R. Henderson, Julie Rayes, David C. Wraith, Steve P. Watson, Max Crispin, Mark T. Drayson, Alex G. Richter, Adam F. Cunningham
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Antibodies specific for the spike glycoprotein (S) and nucleocapsid (N) SARS-CoV-2 proteins are typically present during severe COVID-19, and induced to S after vaccination. The binding of viral antigens by antibody can initiate the classical complem
Externí odkaz:
https://doaj.org/article/e96e183f4c0140d195866a01fcba3220
Autor:
Robert A. Ariëns, Beverley J. Hunt, Ejaife O. Agbani, Josefin Ahnström, Robert Ahrends, Raza Alikhan, Alice Assinger, Zsuzsa Bagoly, Alessandra Balduini, Elena Barbon, Christopher D. Barrett, Paul Batty, Jorge David Aivazoglou Carneiro, Wee Shian Chan, Moniek deMaat, Kerstin deWit, Cécile Denis, Martin H. Ellis, Renee Eslick, Hongxia Fu, Catherine P. M. Hayward, Benoit Ho‐Tin‐Noé, Frederikus A. Klok, Riten Kumar, Karin Leiderman, Rustem I. Litvinov, Nigel Mackman, Zoe McQuilten, Matthew D. Neal, William A. E. Parker, Roger J. S. Preston, Julie Rayes, Alireza R. Rezaie, Lara N. Roberts, Bianca Rocca, Susan Shapiro, Deborah M. Siegal, Lirlândia P. Sousa, Katsue Suzuki‐Inoue, Tahira Zafar, Jiaxi Zhou
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 5, Pp n/a-n/a (2022)
Abstract The ISTH London 2022 Congress is the first held (mostly) face‐to‐face again since the COVID‐19 pandemic took the world by surprise in 2020. For 2 years we met virtually, but this year’s in‐person format will allow the ever‐so‐i
Externí odkaz:
https://doaj.org/article/f79ff8eebaef425b98250762e3be6774
Autor:
Elizabeth J Haining, Kate L Lowe, Surasak Wichaiyo, Raghu P Kataru, Zoltan Nagy, Dean Pj Kavanagh, Sian Lax, Ying Di, Bernhard Nieswandt, Benoît Ho-Tin-Noé, Babak J Mehrara, Yotis A Senis, Julie Rayes, Steve P Watson
Publikováno v:
Platelets, Vol 32, Iss 3, Pp 352-367 (2021)
C-type lectin-like receptor 2 (CLEC-2) is considered as a potential drug target in settings of wound healing, inflammation, and infection. A potential barrier to this is evidence that CLEC-2 and its ligand podoplanin play a critical role in preventin
Externí odkaz:
https://doaj.org/article/a005fc05380f45788ba6052de9029753
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 1, Pp 23-35 (2020)
Abstract Beyond their role in hemostasis and thrombosis, platelets are increasingly recognized as key regulators of the inflammatory response under sterile and infectious conditions. Both platelet receptors and secretion are critical for these functi
Externí odkaz:
https://doaj.org/article/c7ec012f308a4eb1861951ab4c9a7ff8
Autor:
Waltraud C. Schrottmaier, Anita Pirabe, David Pereyra, Stefan Heber, Hubert Hackl, Anna Schmuckenschlager, Laura Brunnthaler, Jonas Santol, Kerstin Kammerer, Justin Oosterlee, Erich Pawelka, Sonja M. Treiber, Abdullah O. Khan, Matthew Pugh, Marianna T. Traugott, Christian Schörgenhofer, Tamara Seitz, Mario Karolyi, Bernd Jilma, Julie Rayes, Alexander Zoufaly, Alice Assinger
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2022)
Coronavirus disease 2019 (COVID-19) induces a hypercoagulatory state that frequently leads to thromboembolic complications. Whereas anticoagulation is associated with reduced mortality, the role of antiplatelet therapy in COVID-19 is less clear. We r
Externí odkaz:
https://doaj.org/article/aa45ea165912461dbabdad4a74abcca7
Autor:
Waltraud C. Schrottmaier, Anita Pirabe, David Pereyra, Stefan Heber, Hubert Hackl, Anna Schmuckenschlager, Laura Brunnthaler, Jonas Santol, Kerstin Kammerer, Justin Oosterlee, Erich Pawelka, Sonja M. Treiber, Abdullah O. Khan, Matthew Pugh, Marianna T. Traugott, Christian Schörgenhofer, Tamara Seitz, Mario Karolyi, Bernd Jilma, Julie Rayes, Alexander Zoufaly, Alice Assinger
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Thromboembolic complications are frequently observed in Coronavirus disease 2019 (COVID-19). While COVID-19 is linked to platelet dysregulation, the association between disease outcome and platelet function is less clear. We prospectively monitored p
Externí odkaz:
https://doaj.org/article/95669424e98c45f4b6455fb6feb38854
Autor:
Joshua H. Bourne, Nonantzin Beristain-Covarrubias, Malou Zuidscherwoude, Joana Campos, Ying Di, Evelyn Garlick, Martina Colicchia, Lauren V. Terry, Steven G. Thomas, Alexander Brill, Jagadeesh Bayry, Steve P. Watson, Julie Rayes
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Platelets play a key role in the development, progression and resolution of the inflammatory response during sterile inflammation and infection, although the mechanism is not well understood. Here we show that platelet CLEC-2 reduces tissue inflammat
Externí odkaz:
https://doaj.org/article/b064efb78360449f877099d157169844