Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Julie Rageul"'
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113845- (2024)
Summary: Poly(ADP-ribosyl)ation (PARylation), catalyzed mainly by poly(ADP-ribose) polymerase (PARP)1, is a key posttranslational modification involved in DNA replication and repair. Here, we report that TIMELESS (TIM), an essential scaffold of the r
Externí odkaz:
https://doaj.org/article/ae9ca411df6643539036298289895f18
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10488 (2023)
DNA replication is a tightly controlled process that ensures the faithful duplication of the genome. However, DNA damage arising from both endogenous and exogenous assaults gives rise to DNA replication stress associated with replication fork slowing
Externí odkaz:
https://doaj.org/article/ee3115a4b6a048e083e53df37010d533
Autor:
Julie Rageul, Jennifer J. Park, Ping Ping Zeng, Eun-A Lee, Jihyeon Yang, Sunyoung Hwang, Natalie Lo, Alexandra S. Weinheimer, Orlando D. Schärer, Jung-Eun Yeo, Hyungjin Kim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The fork protection complex (FPC), including the proteins TIMELESS and TIPIN, stabilizes the replisome to ensure unperturbed fork progression during DNA replication. Here the authors reveal that that SDE2, a PCNA-associated protein, plays an importan
Externí odkaz:
https://doaj.org/article/cf4354514492419cabdbc66606aed2dc
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 1 (2021)
The fork protection complex (FPC), comprising the TIMELESS (TIM)-TIPIN heterodimer, acts as a scaffold of the replisome to support seamless DNA replication. We recently showed that SDE2, a PCNA-associated DNA replication stress regulator, maintains t
Externí odkaz:
https://doaj.org/article/93f18177877144fd95aef61410d1a305
Publikováno v:
Nucleic Acids Research.
The structure of DNA replication forks is preserved by TIMELESS (TIM) in the fork protection complex (FPC) to support seamless fork progression. While the scaffolding role of the FPC to couple the replisome activity is much appreciated, the detailed
Autor:
Alexandra S. Weinheimer, YiTing Paung, Julie Rageul, Arafat Khan, Brian Ho, Michael Tong, Sébastien Alphonse, Markus A. Seeliger, Hyungjin Kim
Elevated DNA replication stress causes instability of the DNA replication fork and DNA mutations, which underlies tumorigenesis. The DNA replication stress regulator SDE2 binds to TIMELESS (TIM) of the fork protection complex (FPC) and enhances its s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb8b6fafea03ea3779c79e25ca081a6c
https://doi.org/10.1101/2022.05.09.490802
https://doi.org/10.1101/2022.05.09.490802
Autor:
Alexandra S. Weinheimer, YiTing Paung, Julie Rageul, Arafat Khan, Natalie Lo, Brian Ho, Michael Tong, Sébastien Alphonse, Markus A. Seeliger, Hyungjin Kim
Publikováno v:
The Journal of biological chemistry. 298(8)
Elevated DNA replication stress causes instability of the DNA replication fork and increased DNA mutations, which underlies tumorigenesis. The DNA replication stress regulator silencing-defective 2 (SDE2) is known to bind to TIMELESS (TIM), a protein
Autor:
Ukhyun Jo, Hyungjin Kim, Alexandra S. Weinheimer, Jennifer J. Park, Tri T. M. Vu, Julie Rageul
Publikováno v:
Nucleic Acids Research
Multiple pathways counteract DNA replication stress to prevent genomic instability and tumorigenesis. The recently identified human SDE2 is a genome surveillance protein regulated by PCNA, a DNA clamp and processivity factor at replication forks. Her
Publikováno v:
Mol Cell Oncol
The fork protection complex (FPC), comprising the TIMELESS (TIM)-TIPIN heterodimer, acts as a scaffold of the replisome to support seamless DNA replication. We recently showed that SDE2, a PCNA-associated DNA replication stress regulator, maintains t
Autor:
Ping Ping Zeng, Jung-Eun Yeo, Hyungjin Kim, Sunyoung Hwang, Jennifer J. Park, Julie Rageul, Alexandra S. Weinheimer, Jihyeon Yang, Natalie Lo, Orlando D. Schärer, Eun-A Lee
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Protecting replication fork integrity during DNA replication is essential for maintaining genome stability. Here, we report that SDE2, a PCNA-associated protein, plays a key role in maintaining active replication and counteracting replication stress