Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Julie R. Perlin"'
Autor:
Vera Binder, Wantong Li, Muhammad Faisal, Konur Oyman, Donn L. Calkins, Jami Shaffer, Emily M. Teets, Steven Sher, Andrew Magnotte, Alex Belardo, William Deruelle, T. Charles Gregory, Shelley Orwick, Elliott J. Hagedorn, Julie R. Perlin, Serine Avagyan, Asher Lichtig, Francesca Barrett, Michelle Ammerman, Song Yang, Yi Zhou, William E. Carson, Heather R. Shive, James S. Blachly, Rosa Lapalombella, Leonard I. Zon, Bradley W. Blaser
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112528- (2023)
Summary: Altered hematopoietic stem cell (HSC) fate underlies primary blood disorders but microenvironmental factors controlling this are poorly understood. Genetically barcoded genome editing of synthetic target arrays for lineage tracing (GESTALT)
Externí odkaz:
https://doaj.org/article/b0783af216d541e48c1e8e6815eda5bc
Autor:
Lindsay N. Theodore, Elliott J. Hagedorn, Mauricio Cortes, Kelsey Natsuhara, Sarah Y. Liu, Julie R. Perlin, Song Yang, Madeleine L. Daily, Leonard I. Zon, Trista E. North
Publikováno v:
Stem Cell Reports, Vol 8, Iss 5, Pp 1226-1241 (2017)
Hematopoietic stem/progenitor cells (HSPCs) are formed during ontogeny from hemogenic endothelium in the ventral wall of the dorsal aorta (VDA). Critically, the cellular mechanism(s) allowing HSPC egress and migration to secondary niches are incomple
Externí odkaz:
https://doaj.org/article/7879a997547d4b23878d919f932b192d
Autor:
Elliott J. Hagedorn, Julie R. Perlin, Rebecca J. Freeman, Samuel J. Wattrus, Tianxiao Han, Clara Mao, Ji Wook Kim, Inés Fernández-Maestre, Madeleine L. Daily, Christopher D’Amato, Michael J. Fairchild, Raquel Riquelme, Brian Li, Dana A.V.E. Ragoonanan, Khaliun Enkhbayar, Emily L. Henault, Helen G. Wang, Shelby E. Redfield, Samantha H. Collins, Asher Lichtig, Song Yang, Yi Zhou, Balvir Kunar, Jesus Maria Gomez-Salinero, Thanh T. Dinh, Junliang Pan, Karoline Holler, Henry A. Feldman, Eugene C. Butcher, Alexander van Oudenaarden, Shahin Rafii, J. Philipp Junker, Leonard I. Zon
The hematopoietic niche is a supportive microenvironment composed of distinct cell types, including specialized vascular endothelial cells that directly interact with hematopoietic stem and progenitor cells (HSPCs). The molecular factors that specify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b90a91fb7a197e73cc3374b0f18cdb
http://edoc.mdc-berlin.de/23329/7/23329suppl.zip
http://edoc.mdc-berlin.de/23329/7/23329suppl.zip
Autor:
Isaac Adatto, Ying Wang, Stuart L. Schreiber, Leonard I. Zon, Lucas B. Sullivan, Raha Weigert, Chad A. Cowan, Bilguujin Dorjsuren, Partha P. Nag, Marlies P. Rossmann, Siegfried Hekimi, Ilaria Elia, Richard A. Young, Sejal Vyas, James Mullahoo, Julie R. Perlin, Curtis R. Warren, Brian J. Abraham, Alexander Meissner, Song Yang, Malvina Papanastasiou, Sara Hetzel, Victoria Chan, Karen Hoi, Marcia C. Haigis, Elliott J. Hagedorn, Eugenia Custo Greig, Steven A. Carr
Publikováno v:
Science
Metabolic pathway regulates cell fate Lineage-specific regulators direct cell fate decisions, but the precise mechanisms are not well known. Using an in vivo chemical suppressor screen of a bloodless zebrafish mutant, Rossmann et al. show that the li
Autor:
Michael J. Fairchild, Rebecca J. Freeman, Khaliun Enkhbayar, Samantha H. Collins, Samuel J. Wattrus, Eugene C. Butcher, Helen G. Wang, Jesus M. Gomez-Salinero, Elliott J. Hagedorn, Julie R. Perlin, Yi Zhou, Inés Fernández-Maestre, Brian Li, Christopher D’Amato, Emily L. Henault, Henry A. Feldman, Thanh Theresa Dinh, Alexander van Oudenaarden, Leonard I. Zon, Shelby E. Redfield, Raquel Riquelme, Shahin Rafii, Asher Lichtig, Song Yang, Karoline Holler, Junliang Pan, Clara Mao, Balvir Kunar, Tianxiao Han, Dana A.V.E. Ragoonanan, Ji Wook Kim, J. Philipp Junker, Madeleine L. Daily
The hematopoietic niche is a supportive microenvironment comprised of distinct cell types, including specialized vascular endothelial cells that directly interact with hematopoietic stem and progenitor cells (HSPCs). The molecular factors that specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b26e49458391b494ac77ae49a8e22607
https://doi.org/10.1101/2021.11.03.467105
https://doi.org/10.1101/2021.11.03.467105
Autor:
Julie R. Perlin, Marsha A. Moses, Nur Mustafaoglu, Golnaz Morad, Leonard I. Zon, Tae-Eun Park, Cassandra C. Daisy, Elliott J. Hagedorn, Christopher V. Carman, Donald E. Ingber
Publikováno v:
ACS Nano. 13:13853-13865
The restrictive nature of the blood-brain barrier (BBB) creates a major challenge for brain drug delivery with current nanomedicines lacking the ability to cross the BBB. Extracellular vesicles (EVs) have been shown to contribute to the progression o
Autor:
Leonard I. Zon, Lauren A. O’Connell, Elliott J. Hagedorn, Eirini Trompouki, Ute Wölfle, Daniel E. Schwarz, Charlotte M. Niemeyer, David E. Fisher, Julie R. Perlin, Friedrich G. Kapp, John M. Gansner, Wolfgang Driever, Chris T. Amemiya, Nicholas S. Johnson
Publikováno v:
Nature
Haematopoietic stem and progenitor cells (HSPCs) require a specific microenvironment, the haematopoietic niche, which regulates HSPC behaviour1,2. The location of this niche varies across species, but the evolutionary pressures that drive HSPCs to di
Publikováno v:
The Journal of Experimental Medicine
Perlin et al. discuss recent findings in the field of zebrafish hematopoiesis, focusing on the transcriptional regulation of hematopoietic stem cell (HSC) induction and HSC–niche interactions. Manipulation of developmental signaling pathways may en
Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment
Publikováno v:
Journal of Molecular Medicine. 95:809-819
Cells of the hematopoietic system undergo rapid turnover. Each day, humans require the production of about one hundred billion new blood cells for proper function. Hematopoietic stem cells (HSCs) are rare cells that reside in specialized niches and a
Autor:
Kelsey Natsuhara, Mauricio Cortes, Sarah Y. Liu, Lindsay N. Theodore, Trista E. North, Elliott J. Hagedorn, Song Yang, Leonard I. Zon, Julie R. Perlin, Madeleine L. Daily
Publikováno v:
Stem Cell Reports, Vol 8, Iss 5, Pp 1226-1241 (2017)
Stem Cell Reports
Stem Cell Reports
Summary Hematopoietic stem/progenitor cells (HSPCs) are formed during ontogeny from hemogenic endothelium in the ventral wall of the dorsal aorta (VDA). Critically, the cellular mechanism(s) allowing HSPC egress and migration to secondary niches are