Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Julie R. McMullen"'
Autor:
Nicola M. Sergienko, Adam J. Trewin, Helen Kiriazis, Antonia J. A. Raaijmakers, Daniel G. Donner, Victoria C. Garside, Kelly A. Smith, James R. Bell, Kimberley M. Mellor, Lea M. D. Delbridge, Julie R. McMullen, Kate L. Weeks
Publikováno v:
npj Metabolic Health and Disease, Vol 2, Iss 1, Pp 1-13 (2024)
Abstract Protein phosphatase 2A (PP2A) regulatory subunit B55α has been implicated in the transcriptional regulation of cardiac growth and fibrosis by suppressing HDAC5/MEF2 signalling in cardiomyocytes. We created and characterised two mouse models
Externí odkaz:
https://doaj.org/article/962f0a0f34444cd0b5607aa60b031817
Deletion of the muscle enriched lncRNA Oip5os1 induces atrial dysfunction in male mice with diabetes
Autor:
Aowen Zhuang, Yanie Tan, Yingying Liu, Christine Yang, Helen Kiriazis, Kyah Grigolon, Shannen Walker, Simon T. Bond, Julie R. McMullen, Anna C. Calkin, Brian G. Drew
Publikováno v:
Physiological Reports, Vol 11, Iss 23, Pp n/a-n/a (2023)
Abstract Long ncRNAs (lncRNAs) have been shown to play a biological and physiological role in various tissues including the heart. We and others have previously established that the lncRNA Oip5os1 (1700020I14Rik, OIP5‐AS1, Cyrano) is enriched in st
Externí odkaz:
https://doaj.org/article/1b95d6a3a9ba480f80f77c3578a83ad1
Publikováno v:
Journal of Sport and Health Science, Vol 10, Iss 6, Pp 637-647 (2021)
Heart failure represents the end point of a variety of cardiovascular diseases. It is a growing health burden and a leading cause of death worldwide. To date, limited treatment options exist for the treatment of heart failure, but exercise has been w
Externí odkaz:
https://doaj.org/article/65d4df39025b4588a915ed4274ed9b9c
Autor:
Gabriella E. Farrugia, Micheal A. McLellan, Kate L. Weeks, Aya Matsumoto, Charles D. Cohen, Crisdion Krstevski, Taylah L. Gaynor, Adam C. Parslow, Julie R. McMullen, Alexander R. Pinto
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100866- (2021)
Summary: This protocol features parallel isolation of myocytes and non-myocytes from murine hearts. It was designed with considerations for (1) time required to extract cardiac cells, (2) cell viability, and (3) protocol scalability. Here, a peristal
Externí odkaz:
https://doaj.org/article/e554ac6acc834cce8edb2df50ff09a7e
Autor:
Simon T. Bond, Aowen Zhuang, Christine Yang, Eleanor A.M. Gould, Tim Sikora, Yingying Liu, Ying Fu, Kevin I. Watt, Yanie Tan, Helen Kiriazis, Graeme I. Lancaster, Paul Gregorevic, Darren C. Henstridge, Julie R. McMullen, Peter J. Meikle, Anna C. Calkin, Brian G. Drew
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101292- (2021)
Objective: CRISPR/Cas9 technology has revolutionized gene editing and fast tracked our capacity to manipulate genes of interest for the benefit of both research and therapeutic applications. Whilst many advances have, and continue to be made in this
Externí odkaz:
https://doaj.org/article/9b56d5f453674ef7a4d560824691508a
Autor:
Bianca C. Bernardo, Gunes S. Yildiz, Helen Kiriazis, Claudia A. Harmawan, Celeste M. K. Tai, Rebecca H. Ritchie, Julie R. McMullen
Publikováno v:
Cells, Vol 11, Iss 19, p 3117 (2022)
MicroRNA 34a (miR-34a) is elevated in the heart in a setting of cardiac stress or pathology, and we previously reported that inhibition of miR-34a in vivo provided protection in a setting of pressure overload-induced pathological cardiac hypertrophy
Externí odkaz:
https://doaj.org/article/cbe1a51af347431b9d1db920218b859c
Autor:
Aowen Zhuang, Anna C. Calkin, Shannen Lau, Helen Kiriazis, Daniel G. Donner, Yingying Liu, Simon T. Bond, Sarah C. Moody, Eleanor A.M. Gould, Timothy D. Colgan, Sergio Ruiz Carmona, Michael Inouye, Thomas Q. de Aguiar Vallim, Elizabeth J. Tarling, Gregory A. Quaife-Ryan, James E. Hudson, Enzo R. Porrello, Paul Gregorevic, Xiao-Ming Gao, Xiao-Jun Du, Julie R. McMullen, Brian G. Drew
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102537- (2021)
Summary: Long non-coding RNAs (lncRNAs) have been demonstrated to influence numerous biological processes, being strongly implicated in the maintenance and physiological function of various tissues including the heart. The lncRNA OIP5-AS1 (1700020I14
Externí odkaz:
https://doaj.org/article/453eb2947cf84c34a110e74e3feab67a
Autor:
Reem Handklo-Jamal, Eshcar Meisel, Daniel Yakubovich, Leonid Vysochek, Roy Beinart, Michael Glikson, Julie R. McMullen, Nathan Dascal, Eyal Nof, Shimrit Oz
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Andersen–Tawil syndrome (ATS) type-1 is associated with loss-of-function mutations in KCNJ2 gene. KCNJ2 encodes the tetrameric inward-rectifier potassium channel Kir2.1, important to the resting phase of the cardiac action potential. Kir-channels
Externí odkaz:
https://doaj.org/article/59e92be68263490f9449fdc8120a03c5
Autor:
Yow Keat Tham, Bianca C. Bernardo, Kevin Huynh, Jenny Y.Y. Ooi, Xiao Ming Gao, Helen Kiriazis, Corey Giles, Peter J. Meikle, Julie R. McMullen
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2757-2772 (2018)
Summary: Exercise-induced heart growth provides protection against cardiovascular disease, whereas disease-induced heart growth leads to heart failure. These distinct forms of growth are associated with different molecular profiles (e.g., mRNAs, non-
Externí odkaz:
https://doaj.org/article/8141d5ca40064210923f96be04c475cf
Autor:
Somy Yoon, Taewon Kook, Hyun-Ki Min, Duk-Hwa Kwon, Young Kuk Cho, Mira Kim, Sera Shin, Hosouk Joung, Seung Hoon Jeong, Sumin Lee, Gaeun Kang, Yunchul Park, Yong Sook Kim, Youngkeun Ahn, Julie R. McMullen, Ulrich Gergs, Joachim Neumann, Kyung Keun Kim, Jungchul Kim, Kwang-Il Nam, Young-Kook Kim, Hyun Kook, Gwang Hyeon Eom
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 7, Pp 1-14 (2018)
Cardiovascular disease: A brake for heart muscle growth A regulatory mechanism that controls how cardiac muscle responds to stress could inform development of new therapies for preventing heart failure. Physiological stimuli ranging from heavy exerci
Externí odkaz:
https://doaj.org/article/baf03256eb114ec282a4f7cff143152e