Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Julie Qiaojin, Lin"'
Publikováno v:
BJPsych Open, Vol 10, Pp S20-S21 (2024)
Aims Local protein synthesis at the synapse is a key determinant of learning and memory and is predicted to be severely disrupted in Alzheimer's disease (AD). Omics approaches have played a key role in deciphering molecular mechanisms underlying AD p
Externí odkaz:
https://doaj.org/article/00406ea0eea34760be892965194bd75b
Autor:
Florian Ströhl, Julie Qiaojin Lin, Romain F. Laine, Hovy Ho-Wai Wong, Vasja Urbančič, Roberta Cagnetta, Christine E. Holt, Clemens F. Kaminski
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
Abstract Local mRNA translation occurs in growing axons enabling precise control of the proteome in response to signals. To measure quantitatively the spatiotemporal dynamics of protein synthesis in growth cones, we further developed a technique for
Externí odkaz:
https://doaj.org/article/2cb1a78828434275beac474015e8c8e8
Autor:
Toshiaki Shigeoka, Max Koppers, Hovy Ho-Wai Wong, Julie Qiaojin Lin, Roberta Cagnetta, Asha Dwivedy, Janaina de Freitas Nascimento, Francesca W. van Tartwijk, Florian Ströhl, Jean-Michel Cioni, Julia Schaeffer, Mark Carrington, Clemens F. Kaminski, Hosung Jung, William A. Harris, Christine E. Holt
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3605-3619.e10 (2019)
Summary: Ribosome assembly occurs mainly in the nucleolus, yet recent studies have revealed robust enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far away from neuronal cell bodies. Here, we report a physical and
Externí odkaz:
https://doaj.org/article/03a40e7b28d94e35809090a5ff021644
Autor:
Max Koppers, Roberta Cagnetta, Toshiaki Shigeoka, Lucia CS Wunderlich, Pedro Vallejo-Ramirez, Julie Qiaojin Lin, Sixian Zhao, Maximilian AH Jakobs, Asha Dwivedy, Michael S Minett, Anaïs Bellon, Clemens F Kaminski, William A Harris, John G Flanagan, Christine E Holt
Publikováno v:
eLife, Vol 8 (2019)
Extrinsic cues trigger the local translation of specific mRNAs in growing axons via cell surface receptors. The coupling of ribosomes to receptors has been proposed as a mechanism linking signals to local translation but it is not known how broadly t
Externí odkaz:
https://doaj.org/article/9b3b40d5ede643c89c36904b516f8db7
Autor:
Kin-Mei Leung, Bo Lu, Hovy Ho-Wai Wong, Julie Qiaojin Lin, Benita Turner-Bridger, Christine E. Holt
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Guidance cues trigger fast responses in axonal growth cones such as directional turning and collapse that require local protein synthesis. An attractive cue-gradient, such as Netrin-1, triggers de novo synthesis of β-actin localized to the near-side
Externí odkaz:
https://doaj.org/article/add87adb65ed4067a626ccb64f061e1e
Autor:
Julie Qiaojin Lin, Deepak Khuperkar, Sofia Pavlou, Stanislaw Makarchuk, Nikolaos Patikas, Flora C.Y. Lee, Jianning Kang, Sarah F. Field, Julia M. Zbiegly, Joshua L. Freeman, Jernej Ule, Emmanouil Metzakopian, Marc-David Ruepp, Giovanna R. Mallucci
SummaryEnhanced expression of the cold-shock protein RNA binding motif 3 (RBM3) is highly neuroprotective bothin vitroandin vivo. Whilst upstream signalling pathways leading to RBM3 expression have been described, the precise molecular mechanism of R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad63196bea6cb848a60d6e1de5dec639
https://doi.org/10.1101/2022.10.27.514062
https://doi.org/10.1101/2022.10.27.514062
Autor:
Francesca W. van Tartwijk, Lucia C.S. Wunderlich, Ioanna Mela, Stanislaw Makarchuk, Maximilian A.H Jakobs, Seema Qamar, Kristian Franze, Gabriele S. Kaminski Schierle, Peter H. St George-Hyslop, Julie Qiaojin Lin, Christine E. Holt, Clemens F. Kaminski
SummaryAberrant condensation and localisation of the RNA-binding protein fused in sarcoma (FUS) occur in variants of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is also associated with cytoskeletal defects, genetically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e03fe14942870500e921c036c1d64e9
https://doi.org/10.1101/2022.10.04.510780
https://doi.org/10.1101/2022.10.04.510780
Autor:
Julie Qiaojin, Lin, Jean-Michel, Cioni
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2431
In neurons, specific mRNAs are transported into axons, where their local translation supports essential cellular functions. Over the years, our knowledge of the molecular mechanisms underlying axonal mRNA translation has rapidly expanded. However, to
Autor:
Jean-Claude Tinguely, Francesca W. van Tartwijk, Gabriele S. Kaminski-Schierle, Oliver Vanderpoorten, Julie Qiaojin Lin, Clemens F. Kaminski, Florian Ströhl, Balpreet Singh Ahluwalia, Firehun Tsige Dullo, Ida Sundvor Opstad, Marcus Fantham, Colin Hockings
Publikováno v:
Journal of Biophotonics
Large fields of view (FOVs) in total internal reflection fluorescence microscopy (TIRFM) via waveguides have been shown to be highly beneficial for single molecule localisation microscopy on fixed cells [1, 2] and have also been demonstrated for shor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f109ab646579b9484e79d1dd2592b27
https://www.repository.cam.ac.uk/handle/1810/304376
https://www.repository.cam.ac.uk/handle/1810/304376
Autor:
David Holcman, Charles N. Christensen, Christine E. Holt, Lukas C. Kapitein, Pierre Parutto, Francesca W. van Tartwijk, Gabriele Kaminski Schierle, Edward Avezov, Julie Qiaojin Lin, Wilco Nijenhuis, Alan Tunnacliffe, Clemens F. Kaminski, Marcus Fantham, Meng Lu
The endoplasmic reticulum (ER) comprises morphologically and functionally distinct domains, sheets and interconnected tubules. These domains undergo dynamic reshaping, in response to changes in the cellular environment. However, the mechanisms behind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a46910510a4aad14fe65196fe4b9b2
https://doi.org/10.1101/2020.01.15.907444
https://doi.org/10.1101/2020.01.15.907444