Both gain‐of‐function and loss‐of‐functionde novoCACNA1Amutations cause severe developmental epileptic encephalopathies in the spectrum of Lennox‐Gastaut syndrome

Autor: Nazzareno D'Avanzo, Tyler Mark Pierson, Elsa Rossignol, Mathieu Lachance, Berge A. Minassian, Julie Pepin, Praveen K. Raju, Jean-Claude Lacaille, François Dubeau, Xiao Jiang, Luis Bello-Espinosa, Wendy G. Mitchell

Publikováno v: Epilepsia. 60:1881-1894

Objective Developmental epileptic encephalopathies (DEEs) are genetically heterogeneous severe childhood-onset epilepsies with developmental delay or cognitive deficits. In this study, we explored the pathogenic mechanisms of DEE-associated de novo m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42be6533fbe5aabf3a9d8747024d0eeb
https://doi.org/10.1111/epi.16316

Sample scale testing method to prevent collapse of plastic liners in composite pressure vessels

Autor: Jean-Claude Grandidier, Philippe Renault, Philippe Papin, G. Tantchou, Pierre Blanc-Vannet, Mathilde Weber, Sylvie Castagnet, Julie Pepin, Eric Lainé

Publikováno v: International Journal of Hydrogen Energy
International Journal of Hydrogen Energy, Elsevier, 2019, 44 (17), pp.8682-8691. ⟨10.1016/j.ijhydene.2018.10.031⟩

International audience; Type IV pressure vessels are commonly used for hydrogen on-board, stationary or bulk storages. When pressurised, hydrogen permeates through the materials and solves into them. Emptying then leads to a difference of pressure at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9b872c92c0b1023fbbabeea912c949
https://hal.archives-ouvertes.fr/hal-02284726

Replication of liner collapse phenomenon observed in hyperbaric type IV hydrogen storage vessel by explosive decompression experiments

Autor: Mathilde Weber, Christophe Langlois, David Mellier, Jean-Claude Grandidier, Julie Pepin, Guillaume Benoit, Eric Lainé

Publikováno v: International Journal of Hydrogen Energy
International Journal of Hydrogen Energy, Elsevier, 2018, 43 (9), pp.4671-4680. ⟨10.1016/j.ijhydene.2018.01.022⟩

International audience; An experimental design based on representative sample is described in order to reproduce the detachment and deformation of the inner polymer layer (called liner) of hyperbaric hydrogen storage vessels during the emptying step.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5856006a37417f68aac14b7a033d3f
https://hal.archives-ouvertes.fr/hal-02308763

New Insights into the Brill Transition in Polyamide 11 and Polyamide 6

Autor: Jean-Marc Lefebvre, Julie Pepin, V. Miri

Publikováno v: Macromolecules
Macromolecules, American Chemical Society, 2016, 49 (2), pp.564-573. ⟨10.1021/acs.macromol.5b01701⟩
Macromolecules, 2016, 49 (2), pp.564-573. ⟨10.1021/acs.macromol.5b01701⟩

The thermal stability of several crystal polymorphs in polyamide 11 (PA11) and polyamide 6 (PA6) has been investigated by means of in situ X-ray experiments. In the case of PA11, δ′ and α′ phases display a Brill transition far below the melting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6b2d91b4410a394e5867df9f04549c
https://hal-univ-tours.archives-ouvertes.fr/hal-03538230

alpha8beta1 Integrin is up-regulated in the neointima concomitant with late luminal loss after balloon injury

Autor: Julie Pepin, Ramin Zargham, Gaétan Thibault

Publikováno v: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 16(4)

Introduction Constrictive remodeling of the neointima results in the late lumen loss and restenosis after balloon angioplasty. Intense expression of alpha8beta1 integrin in the contractile state of vascular smooth muscle cells (VSMCs) and in myofibro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f75bd7c791e506c817702bc916eafc
https://pubmed.ncbi.nlm.nih.gov/17637429