Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Julie P I Welburn"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010611 (2022)
Cells rely heavily on microtubules for several processes, including cell division and molecular trafficking. Mutations in the different tubulin-α and -β proteins that comprise microtubules have been associated with various diseases and are often do
Externí odkaz:
https://doaj.org/article/8aefe6dabbe54b2086f8010db5107356
Autor:
Haonan Liu, Julie P. I. Welburn
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
Platelets are blood cells derived from megakaryocytes that play a central role in regulating haemostasis and vascular integrity. The microtubule cytoskeleton of megakaryocytes undergoes a critical dynamic reorganization during cycles of endomitosis a
Externí odkaz:
https://doaj.org/article/c8ce426a27944dba88fa91862efdd31d
Publikováno v:
Open Biology, Vol 12, Iss 3 (2022)
CENP-E is a large kinesin motor protein which plays pivotal roles in mitosis by facilitating chromosome capture and alignment, and promoting microtubule flux in the spindle. So far, it has not been possible to obtain active human CENP-E to study its
Externí odkaz:
https://doaj.org/article/5c1c30fa157841c3baf37913e8e01ba4
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Protein kinases are major regulators of mitosis, with over 30% of the mitotic proteome phosphorylated on serines, threonines and tyrosines. The human genome encodes for 518 kinases that have a structurally conserved catalytic domain and includes abou
Externí odkaz:
https://doaj.org/article/9d2336d823114ff0aed99f419f88cbb6
Publikováno v:
Biology Open, Vol 3, Iss 12, Pp 1217-1223 (2014)
Spindle length varies dramatically across species and during early development to segregate chromosomes optimally. Both intrinsic factors, such as regulatory molecules, and extrinsic factors, such as cytoplasmic volume, determine spindle length scali
Externí odkaz:
https://doaj.org/article/841a863b2a734e88bc4f206cd2fe5ecd
Autor:
Toni McHugh, Julie P. I. Welburn
Publikováno v:
Mchugh, T & Welburn, J P I 2022, ' Potent microtubule depolymerizing activity of a mitotic Kif18b-MCAK-EB network ', Journal of Cell Science, vol. 136, no. 5, jcs260144 . https://doi.org/10.1242/jcs.260144
The precise regulation of microtubule length during mitosis is essential to assemble and position the mitotic spindle and segregate chromosomes. The kinesin-13 Kif2C or MCAK acts as a potent microtubule depolymerase that diffuses short distances on m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa847ffb346b6c2d4e1be8107976e514
https://pubmed.ncbi.nlm.nih.gov/35502670
https://pubmed.ncbi.nlm.nih.gov/35502670
Publikováno v:
Open Biology, Vol 6, Iss 3 (2016)
Mitosis is a highly regulated process that allows the equal distribution of the genetic material to the daughter cells. Chromosome segregation requires the formation of a bipolar mitotic spindle and assembly of a multi-protein structure termed the ki
Externí odkaz:
https://doaj.org/article/4cb0e041022648d99da4592541f7ee94
Publikováno v:
Frontiers in Cell and Developmental Biology
Protein kinases are major regulators of mitosis, with over 30% of the mitotic proteome phosphorylated on serines, threonines and tyrosines. The human genome encodes for 518 kinases that have a structurally conserved catalytic domain and includes abou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aa307a4f18fff04e044078968bed40b5
https://pubmed.ncbi.nlm.nih.gov/29459892
https://pubmed.ncbi.nlm.nih.gov/29459892