Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Julie P Deans"'
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9369 (2010)
The MS4A gene family in humans includes CD20 (MS4A1), FcRbeta (MS4A2), Htm4 (MS4A3), and at least 13 other syntenic genes encoding membrane proteins, most having characteristic tetraspanning topology. Expression of MS4A genes is variable in tissues t
Externí odkaz:
https://doaj.org/article/ad30da9354e64111adcdc4f6e0a65ccc
Publikováno v:
The Journal of Immunology. 191:3112-3118
CD20 is a tetraspanning membrane protein expressed on B lymphocytes. CD20 deficiency in both mice and humans has recently been shown to have deleterious effects on Ab responses to T-independent Ags; however, no effect on T-dependent immunity has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d63857dbc72732445447b6f58cba16
https://doi.org/10.4049/jimmunol.1202098
https://doi.org/10.4049/jimmunol.1202098
Publikováno v:
Journal of Biological Chemistry. 283:18545-18552
B cell antigen receptor (BCR) signaling initiates sustained cellular calcium influx necessary for the development, differentiation, and activation of B lymphocytes. CD20 is a B cell-restricted tetraspanning protein organized in the plasma membrane as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df5e659697bdf7037f94a21cae232885
https://doi.org/10.1074/jbc.m800784200
https://doi.org/10.1074/jbc.m800784200
Autor:
Tammy L. Unruh, Weiguo Zhang, Minghua Zhu, Ratna Sanyal, Lana Grigoriou, Cathlin M. Mutch, Julie P. Deans
Publikováno v:
International Immunology. 19:19-30
Linker for activation of B cell (LAB)/non-T cell activation linker (NTAL) and phosphoprotein associated with glycophospholipid-enriched membrane microdomain (PAG)/Csk-binding protein (Cbp) are raft-associated transmembrane adaptor proteins with disti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a0878cde483be0a374e42f5fafa905
https://doi.org/10.1093/intimm/dxl118
https://doi.org/10.1093/intimm/dxl118
Publikováno v:
Leukemia Research. 28:1197-1202
Here we report that B cell receptor (BCR) engagement rapidly improves the capacity of CD20 to be accessed by cognate antibody at model Burkitt’s lymphoma cell surfaces. None of eight other surface molecules demonstrated such BCR-dependent enhanceme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528995f48bb95277bc69ecd356fb4bf9
https://doi.org/10.1016/j.leukres.2004.02.008
https://doi.org/10.1016/j.leukres.2004.02.008
Autor:
Neda Shariat, Julie P. Deans, Kamala D. Patel, Linda M. Ayer, Ryan J. Petrie, Maria J. Polyak, Andrew R.E. Shaw, Michael J. Hendzel, Haidong Li, Cathlin M. Mutch, Laura R Gauthier
Publikováno v:
Journal of Biological Chemistry. 279:19893-19901
CD20 is a B cell-specific membrane protein that functions in store-operated calcium entry and serves as a useful target for antibody-mediated therapeutic depletion of B cells. Antibody binding to CD20 induces a diversity of biological effects, some o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f22ce5b7e5cee082f390b007277755b0
https://doi.org/10.1074/jbc.m400525200
https://doi.org/10.1074/jbc.m400525200
Publikováno v:
Journal of Biological Chemistry. 278:42427-42434
B cell activation requires sustained elevation of cytoplasmic free calcium, achieved by influx through store-operated calcium (SOC) channels. The molecular identity of these channels is not known. Ectopic expression of the raft-associated tetraspan p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6bf6990c947603ed3c643193718796
https://doi.org/10.1074/jbc.m308802200
https://doi.org/10.1074/jbc.m308802200
Publikováno v:
Immunology. 107:176-182
CD20 is an effective target for therapeutic B-cell depletion with monoclonal antibodies. One proposed mechanism of action is direct cytotoxicity mediated via tyrosine kinase-dependent signalling pathways activated upon CD20 cross-linking. The associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1d196d9ff779c8e0ee81d28b9f8df89
https://doi.org/10.1046/j.1365-2567.2002.01495.x
https://doi.org/10.1046/j.1365-2567.2002.01495.x
Publikováno v:
The Journal of Immunology. 161:3242-3248
CD20 is a B lymphocyte integral membrane protein with signal-transducing properties. Abs directed toward extracellular CD20 epitopes activate nonreceptor tyrosine kinases and modulate cell cycle progression of B lymphocytes. Recently, we demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24fc24e6e351a390ee9016c6a4b22188
https://doi.org/10.4049/jimmunol.161.7.3242
https://doi.org/10.4049/jimmunol.161.7.3242
Publikováno v:
Journal of Biological Chemistry. 273:344-348
CD20 is a B cell integral membrane protein capable of initiating growth-modulating signals in human B lymphocytes upon its engagement with monoclonal anti-CD20 antibodies. In this report, we demonstrate that treatment of B cells with CD20 antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f858641586bbef26b2212e6701c23d00
https://doi.org/10.1074/jbc.273.1.344
https://doi.org/10.1074/jbc.273.1.344