Brain tumours repurpose endogenous neuron to microglia signalling mechanisms to promote their own proliferation

Autor: Kelda Chia, Marcus Keatinge, Julie Mazzolini, Dirk Sieger

Publikováno v: eLife, Vol 8 (2019)

Previously we described direct cellular interactions between microglia and AKT1+ brain tumour cells in zebrafish (Chia et al., 2018). However, it was unclear how these interactions were initiated: it was also not clear if they had an impact on the gr

Externí odkaz: https://doaj.org/article/b9c197a358d740c4b668c1a721bdd91b

Wasl is crucial to maintain microglial core activities during glioblastoma initiation stages

Autor: Jean-François Zagury, Cédric Coulonges, Dirk Sieger, Le Clerc S, Gregoire Morisse, Julie Mazzolini

Publikováno v: Mazzolini, J, Le Clerc, S, Morisse, G, Coulonges, C, Zagury, J-F & Sieger, D 2022, ' Wasl is crucial to maintain microglial core activities during glioblastoma initiation stages ', Glia, vol. 70, no. 6, pp. 1027-1051 . https://doi.org/10.1002/glia.24154

SummaryMicroglia actively promote the growth of high-grade gliomas. Within the glioma microenvironment an activated (amoeboid) microglial morphology has been observed, however the underlying causes and the related impact on microglia functions and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7ab824728af532d830a243d43f3375
https://hdl.handle.net/20.500.11820/cfe69aa8-5dbb-4ad5-86d1-7bc43ea3168a

Gene expression profiling reveals a conserved microglia signature in larval zebrafish

Autor: Julie Mazzolini, Jean-François Zagury, Dirk Sieger, Cédric Coulonges, Laura E. Kuil, Sigrid Le Clerc, Gregoire Morisse, Tjakko J. van Ham

Publikováno v: Glia
GLIA, 68, 298-315. John Wiley & Sons Inc.
Glia, Wiley, 2019, 68 (2), pp.298-315. ⟨10.1002/glia.23717⟩
Mazzolini, J, Le Clerc, S, Morisse, G, Coulonges, C, Kuil, L E, van Ham, T J, Zagury, J-F & Sieger, D 2019, ' Gene expression profiling reveals a conserved microglia signature in larval zebrafish ', Glia . https://doi.org/10.1002/glia.23717

Microglia are the resident macrophages of the brain. Over the past decade, our understanding of the function of these cells has significantly improved. Microglia do not only play important roles in the healthy brain but are involved in almost every b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985ef59c0adfca7f10c7475f2b173b87
https://doi.org/10.1002/glia.23717

Dynamin-Actin Cross Talk Contributes to Phagosome Formation and Closure

Autor: Julie Mazzolini, Florence Niedergang, Floriane Herit, Florence Marie-Anaïs

Publikováno v: Traffic. 17:487-499

Phagocytosis is a mechanism used by macrophages to internalize and eliminate microorganisms or cellular debris. It relies on profound rearrangements of the actin cytoskeleton that is the driving force allowing plasma membrane extension around the par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fc6ba606fe59dea8132439ec31894cd
https://doi.org/10.1111/tra.12386

Author response: Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain

Autor: Kelda Chia, Julie Mazzolini, Marina Mione, Dirk Sieger

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73d188b658959cb5781e5215845e10c4
https://doi.org/10.7554/elife.31918.022