Výsledky vyhledávání - "Julie M. Varghese"

Conducting clinical trials during the COVID-19 pandemic-a collaborative trial network response

Autor: Laura Robison, Rathika Krishnasamy, Andrea Valks, Ruth Stastny, Charani Kiriwandeniya, David W. Johnson, Neil Boudville, Liza A. Vergara, Yeoungjee Cho, Elaine M. Pascoe, Julie M. Varghese, Peta-Anne Paul-Brent, Carmel M. Hawley, Donna Reidlinger, Andrea K. Viecelli, Magid Fahim

Publikováno v: Trials
Trials, Vol 22, Iss 1, Pp 1-9 (2021)

The unprecedented demand placed on healthcare systems from the COVID-19 pandemic has forced a reassessment of clinical trial conduct and feasibility. Consequently, the Australasian Kidney Trials Network (AKTN), an established collaborative research g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b290e75abc3427b89005885a057799a1
https://pubmed.ncbi.nlm.nih.gov/33853661

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Persistent organic pollutants in infants and toddlers: Relationship between concentrations in matched plasma and faecal samples

Autor: Julie M. Varghese, Leisa-Maree Toms, Michael S. McLachlan, Peter D. Sly, Karin English, Andreas Sjödin, Yiqin Chen, Jochen F. Mueller, Lesa L. Aylward

Publikováno v: Environment International, Vol 107, Iss, Pp 82-88 (2017)

Early-childhood biomonitoring of persistent organic pollutants (POPs) is challenging due to the logistic and ethical limitations associated with blood sampling. We investigated using faeces as a non-invasive matrix to estimate internal exposure to PO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176e527479de2e4bd9612d7b88038e1e
http://www.sciencedirect.com/science/article/pii/S016041201730627X

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Pharmacokinetics of Intraperitoneal Cefalothin and Cefazolin in Patients Being Treated for Peritoneal Dialysis-Associated Peritonitis

Autor: Dwarakanathan Ranganathan, Julie M. Varghese, Jeffrey Lipman, Jason A. Roberts, Darren M. Roberts, A. Kark, Steven C. Wallis

Publikováno v: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis. 36:415-420

BackgroundThe standard treatment of peritoneal dialysis (PD)-associated peritonitis (PD-peritonitis) is intraperitoneal (IP) administration of antibiotics. Only limited data on the pharmacokinetics and appropriateness of contemporary dose recommendat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc54e246ac385331f330632166e4fd25
https://doi.org/10.3747/pdi.2015.00008

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Are interstitial fluid concentrations of meropenem equivalent to plasma concentrations in critically ill patients receiving continuous renal replacement therapy?

Autor: Robert J. Boots, Paul Jarrett, Jeffrey Lipman, Jason A. Roberts, Carl M. J. Kirkpatrick, Steven C. Wallis, Julie M. Varghese

Publikováno v: Journal of Antimicrobial Chemotherapy. 70:528-533

Free to read on publisher's website Objectives To describe the interstitial fluid (ISF) and plasma pharmacokinetics of meropenem in patients on continuous venovenous haemodiafiltration (CVVHDF). Patients and methods This was a prospective observation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8de2055e5e572ca9c463923b4962e81
https://doi.org/10.1093/jac/dku413

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Subtherapeutic Initial β-Lactam Concentrations in Select Critically Ill Patients

Autor: Jason A. Roberts, Jeffrey Lipman, Scott Briscoe, Mahdi Altukroni, Julie M. Varghese, Andrew A. Udy, Jacobus P.J. Ungerer, Brett C. McWhinney

Publikováno v: Chest. 142:30-39

Background β-Lactams are routinely used as empirical therapy in critical illness, with extended concentrations above the minimum inhibitory concentration (MIC) of the infecting organism required for effective treatment. Changes in renal function in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::220cec9bc0b279cb1e3c62067849259b
https://doi.org/10.1378/chest.11-1671

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Antimicrobial Pharmacokinetic and Pharmacodynamic Issues in the Critically Ill with Severe Sepsis and Septic Shock

Autor: Jeffrey Lipman, Jason A. Roberts, Julie M. Varghese

Publikováno v: Critical Care Clinics. 27:19-34

Antimicrobial pharmacokinetics (PK) and pharmacodynamics (PD) are important considerations, particularly in critically ill patients with severe sepsis and septic shock. The pathophysiologic changes that occur in these conditions can have a major effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34aeb8124bc29e8e587f219900f3627d
https://doi.org/10.1016/j.ccc.2010.09.006

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Pharmacokinetics and pharmacodynamics in critically ill patients

Autor: Jason A. Roberts, Julie M. Varghese, Jeffrey Lipman

Publikováno v: Current Opinion in Anaesthesiology. 23:472-478

Purpose of review The purpose of this review is to highlight the recently published studies in the area of pharmacokinetics and pharmacodynamics in critically ill patients and ascertain the relevance to clinical practice. Recent findings The majority

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496d53573b130e85195d476b78ce3f0a
https://doi.org/10.1097/aco.0b013e328339ef0a

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Pharmacokinetics of piperacillin and tazobactam in plasma and subcutaneous interstitial fluid in critically ill patients receiving continuous venovenous haemodiafiltration

Autor: Jason A. Roberts, Paul Jarrett, Robert J. Boots, Jeffrey Lipman, Carl M. J. Kirkpatrick, Julie M. Varghese

Publikováno v: International journal of antimicrobial agents. 43(4)

This prospective pharmacokinetic study aimed to describe plasma and interstitial fluid (ISF) pharmacokinetics of piperacillin and tazobactam in critically ill patients on continuous venovenous haemodiafiltration (CVVHDF). Piperacillin/tazobactam (4g/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f810487a33810d9dffdcef74b0fd6317
https://pubmed.ncbi.nlm.nih.gov/24612982

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