Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

Autor: Mike B. Barnkob, Yale S. Michaels, Violaine André, Philip S. Macklin, Uzi Gileadi, Salvatore Valvo, Margarida Rei, Corinna Kulicke, Ji-Li Chen, Vitul Jain, Victoria K. Woodcock, Huw Colin-York, Andreas V. Hadjinicolaou, Youxin Kong, Viveka Mayya, Julie M. Mazet, Gracie-Jennah Mead, Joshua A. Bull, Pramila Rijal, Christopher W. Pugh, Alain R. Townsend, Audrey Gérard, Lars R. Olsen, Marco Fritzsche, Tudor A. Fulga, Michael L. Dustin, E. Yvonne Jones, Vincenzo Cerundolo

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract Semaphorin-3A (SEMA3A) functions as a chemorepulsive signal during development and can affect T cells by altering their filamentous actin (F-actin) cytoskeleton. The exact extent of these effects on tumour-specific T cells are not completely

Externí odkaz: https://doaj.org/article/0037fd20318049ccb1e0d08f25e77331

Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

Autor: Mike B. Barnkob, Yale S. Michaels, Violaine André, Philip S. Macklin, Uzi Gileadi, Salvatore Valvo, Margarida Rei, Corinna Kulicke, Ji-Li Chen, Vitul Jain, Victoria K. Woodcock, Huw Colin-York, Andreas V. Hadjinicolaou, Youxin Kong, Viveka Mayya, Julie M. Mazet, Gracie-Jennah Mead, Joshua A. Bull, Pramila Rijal, Christopher W. Pugh, Alain R. Townsend, Audrey Gérard, Lars R. Olsen, Marco Fritzsche, Tudor A. Fulga, Michael L. Dustin, E. Yvonne Jones, Vincenzo Cerundolo

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)

Externí odkaz: https://doaj.org/article/c91684507e624290b137868f21bb7e7e

Integration of Avidity and Differentiation is enabled by CD8+T-cell sensing of IFN-γ

Autor: Lion F.K. Uhl, Han Cai, Jagdish N. Mahale, Andrew J. MacLean, Julie M. Mazet, Alexander J. He, Doreen Lau, Tim Elliott, Audrey Gerard

The most effective responses to intracellular pathogens have a breadth of T-cell clones with different affinities for their cognate peptide, and a diversity of functional phenotypes, from effector to long-lived memory cells. While high- and low-affin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2656462f929355dd1e1fe6dd8cd24785
https://doi.org/10.1101/2023.03.06.531375

Neutrophilia, lymphopenia and myeloid dysfunction: a living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathology

Autor: Tehmina Bharuchq, Bruce MacLachlan, Ceri Fielding, Adrian L Smith, Fadi Issa, Emily Thornton, Raphael Sanches Peres, Calliope A Dendrou, Dorothée L Berthold, Liliana Cifuentes, Alicia Teijeira Crespo, Elizabeth H Mann, Arvind Sami, Anne Chauveau, Dominic S Alonzi, Anís Gammage, Fabian Fischer, Valentina M T Bart, Fangfang Lu, Miriam O'Hanlon, Lynn B Dustin, Pragati Sabberwal, Ewoud B. Compeer, Mariana Borsa, Rowie Borst, Hannah Almuttaqi, David J Ahern, Eleanor J Pring, Emma Jones, Ester Gea-Mallorquí, Kate Liddiard, Dingxi Zhou, Amy Cross, Sara Danielli, Max Quastel, Shayda Maleki-Toyserkani, Owen R Moon, Ruban Rex Peter Durairaj, Vicky Batchelor, Barbora Schonfeldova, Angus K T Wann, Lorenzo Capitani, Petros Ligoxygakis, Sandra Dimonte, Clara Eléonore Pavillet, Lion F K Uhl, Luke C Davies, Kristin Ladell, Stephanie Jean Hanna, Felix Richter, Freya R Shepherd, Sarah Hulin-Curtis, Stephanie Burnell, Amy Susan Codd, Anita Milicic, Quentin Sattentau, Juliane Brun, David Oliver Scourfield, Sophie Reed, Jan Rehwinkel, Ghada Alsaleh, D Oliver Scourfield, Michael Tellier, Reginald James Matthews, Eleanor Pring, Emma Mitchell, Anna Katharina Simon, Joseph D Wilson, Niamh Richmond, Van Dien Nguyen, Sarah N Lauder, Zihan Zhu, Tharini A Selvakumar, Ana Pires, Cariad Shorten, Richard Williams, Erinke van Grinsven, Sarah Galloway, Aljawharah Alrubayyi, Stephanie J. Hanna, Felix Clemens Richter, Julie M Mazet, Dimitra Peppa, Clarissa Coveney, Awen Gallimore, Cornelia Heuberger, Owen Moon, Ruth Jones, Helene Borrmann, Arthur Dyer, Lucy Chapman, Jelena S Bezbradica, Andrew Godkin, Rebecca Bayliss, Amy S. Codd, Anna M Marzeda, Athena Cavounidis, Patrícia R S Rodrigues, Alice J B Robinson, Ewoud Bernardus Compeer

Publikováno v: Oxford Open Immunology

Destabilization of balanced immune cell numbers and frequencies is a common feature of viral infections. This occurs due to, and further enhances, viral immune evasion and survival. Since the discovery of the Severe Acute Respiratory Syndrome coronav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44a2a9d86eac6ea736510e7a102f26e
https://doi.org/10.1093/oxfimm/iqab016

Imaging of In Situ Interferon Gamma Production in the Mouse Spleen following Listeria monocytogenes Infection

Autor: Julie M, Mazet, Ana L, Chiodetti, Jagdish N, Mahale, Audrey, Gérard

Publikováno v: Journal of visualized experiments : JoVE. (149)

Cytokines are small proteins secreted by cells, mediating cell-cell communications that are crucial for effective immune responses. One characteristic of cytokines is their pleiotropism, as they are produced by and can affect a multitude of cell type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dcac10c678f377c7cabbc5dbd2872bc8
https://pubmed.ncbi.nlm.nih.gov/31380855