Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Julie M. Granka"'
Autor:
Shannon Hateley, Angelica Lopez-Izquierdo, Chuanchau J. Jou, Scott Cho, Joshua G. Schraiber, Shiya Song, Colin T. Maguire, Natalia Torres, Michael Riedel, Neil E. Bowles, Cammon B. Arrington, Brett J. Kennedy, Susan P. Etheridge, Shuping Lai, Chase Pribble, Lindsay Meyers, Derek Lundahl, Jake Byrnes, Julie M. Granka, Christopher A. Kauffman, Gordon Lemmon, Steven Boyden, W. Scott Watkins, Mary Anne Karren, Stacey Knight, J. Brent Muhlestein, John F. Carlquist, Jeffrey L. Anderson, Kenneth G. Chahine, Khushi U. Shah, Catherine A. Ball, Ivor J. Benjamin, Mark Yandell, Martin Tristani-Firouzi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Many rare high-impact variants have been associated with disease, but the origins and functional impact are not always explored. Here, the authors trace the ancestry of a rare high impact atrial fibrillation allele in KCNQ1, and use iPSC-derived card
Externí odkaz:
https://doaj.org/article/fc7dba9c47974f5aa229e04e2b3a9d14
Autor:
Kevin M. Wright, Kristin A. Rand, Amir Kermany, Keith Noto, Don Curtis, Daniel Garrigan, Dmitri Slinkov, Ilya Dorfman, Julie M. Granka, Jake Byrnes, Natalie Myres, Catherine A. Ball, J. Graham Ruby
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 9, Pp 2863-2878 (2019)
We present a massive investigation into the genetic basis of human lifespan. Beginning with a genome-wide association (GWA) study using a de-identified snapshot of the unique AncestryDNA database – more than 300,000 genotyped individuals linked to
Externí odkaz:
https://doaj.org/article/9c40e1d9973c493eb9e8969394dafdaa
Autor:
Eunjung Han, Peter Carbonetto, Ross E. Curtis, Yong Wang, Julie M. Granka, Jake Byrnes, Keith Noto, Amir R. Kermany, Natalie M. Myres, Mathew J. Barber, Kristin A. Rand, Shiya Song, Theodore Roman, Erin Battat, Eyal Elyashiv, Harendra Guturu, Eurie L. Hong, Kenneth G. Chahine, Catherine A. Ball
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Genetic data has led to great advances in our understanding of human evolution and dispersal, but information on more recent events is limited. Here, the authors analyse genotypes from 770,000 US individuals to map the fine-scale population structure
Externí odkaz:
https://doaj.org/article/e99a0ac04ddd404b84d2e573c01d9e36
Autor:
Caitlin S. Pepperell, Amanda M. Casto, Andrew Kitchen, Julie M. Granka, Omar E. Cornejo, Edward C. Holmes, Bruce Birren, James Galagan, Marcus W. Feldman
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8 (2013)
Externí odkaz:
https://doaj.org/article/2856d444e80a4aa6b37adeea87976581
Autor:
W. Scott Watkins, Derek Lundahl, Steven E. Boyden, Shiya Song, Mary Anne Karren, J. Brent Muhlestein, Shannon Hateley, Chuanchau J. Jou, Colin T. Maguire, Jeffrey L. Anderson, Khushi U Shah, Susan P. Etheridge, Kenneth G. Chahine, Brett Kennedy, Martin Tristani-Firouzi, Gordon Lemmon, Lindsay Meyers, Ivor J. Benjamin, Stacey Knight, Chase Pribble, Catherine A. Ball, Shuping Lai, Christopher A. Kauffman, Scott Cho, Cammon B. Arrington, Natalia S. Torres, Michael Riedel, Joshua G. Schraiber, John F. Carlquist, Jake K. Byrnes, Julie M. Granka, Neil E. Bowles, Mark Yandell, Angelica Lopez-Izquierdo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature Communications
The genetic architecture of atrial fibrillation (AF) encompasses low impact, common genetic variants and high impact, rare variants. Here, we characterize a high impact AF-susceptibility allele, KCNQ1 R231H, and describe its transcontinental geograph
Publikováno v:
Blood. 140:1962-1962
Autor:
Caitlin S Pepperell, Amanda M Casto, Andrew Kitchen, Julie M Granka, Omar E Cornejo, Edward C Holmes, Bruce Birren, James Galagan, Marcus W Feldman
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003543 (2013)
Mycobacterium tuberculosis (M.tb), the cause of tuberculosis (TB), is estimated to infect a new host every second. While analyses of genetic data from natural populations of M.tb have emphasized the role of genetic drift in shaping patterns of divers
Externí odkaz:
https://doaj.org/article/936b8319bd2a41989fa279ef87e12b38
Autor:
Don Curtis, Dmitri Slinkov, Natalie M. Myres, Catherine A. Ball, Neal Varner, J. Graham Ruby, Ilya Dorfman, Daniel Garrigan, Keith Noto, Jake K. Byrnes, Amir R. Kermany, Julie M. Granka, Kristin A. Rand, Kevin M. Wright
Publikováno v:
Genetics
Here, Ruby et al. analyze an unprecedented amount of public family tree data from Ancestry and determine that the heritability of human longevity was well below 10%, lower than the widely-held belief that lifespan...
Human life span is a phenoty
Human life span is a phenoty
Autor:
Paul Norman, Marlo Möller, Christopher R. Gignoux, Becca Asquith, Justin W Myrick, Hugo G. Hilton, Nobuyo Yawata, Meng Lin, Brenna M. Henn, Peter Parham, Julie M. Granka, Neda Nemat-Gorgani, Cedric J. Werely, Makoto Yawata, Eileen G. Hoal, Lies Boelen
Publikováno v:
The Journal of Immunology. 200:2640-2655
The functions of human NK cells in defense against pathogens and placental development during reproduction are modulated by interactions of killer cell Ig-like receptors (KIRs) with HLA-A, -B and -C class I ligands. Both receptors and ligands are hig
Autor:
Teng-Kuei Hsu, Christine Decapite, Ofer Shapira, Alessandro Paniccia, Chun Yang, Shivani Mahajan, Richard Bourgon, Peter Ulz, Marvin Bertin, Amit Pasupathy, Julie M. Granka, Adam Drake, C. Jimmy Lin, Tzu-Yu Liu, Preet Kaur, Randall E. Brand, Kaitlyn Coil, Maggie C. Louie, Billie Gould, Hayley Donnella, Amer H. Zureikat, Eric A. Ariazi
Publikováno v:
Cancer Research. 81:PO-007
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with an overall five-year survival rate of 11%. Potential curative resection is possible if the tumor is detected at an early stage, with a five-year survival rate of 42%. The o