Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Julie L. MacIsaac"'
Autor:
Ana I. Hernandez Cordero, Xuan Li, Julia Yang, Chen Xi Yang, Tawimas Shaipanich, Julie L. MacIsaac, Kristy Dever, Michael S. Kobor, Julio Montaner, Marianne Harris, Silvia Guillemi, Shu Fan Paul Man, Don D. Sin, Janice M. Leung
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1261 (2024)
Background: DNA methylation may be a link between HIV, aging, and the increased risk of lung comorbidities. We investigated whether bronchoalveolar lavage (BAL) cells of people living with HIV (PLWH) demonstrate epigenetic disruptions and advanced ep
Externí odkaz:
https://doaj.org/article/f701d3d267eb4a0f96bcf938a909d574
Autor:
Clarus Leung, Min Hyung Ryu, Anette Kocbach Bølling, Danay Maestre-Batlle, Christopher F. Rider, Anke Hüls, Oscar Urtatiz, Julie L. MacIsaac, Kevin Soon-Keen Lau, David Tse Shen Lin, Michael S. Kobor, Chris Carlsten
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background Single nucleotide polymorphisms (SNPs) of peroxisome proliferator-activated receptor gamma (PPAR-γ; gene: PPARG) and oxidative stress genes are associated with asthma risk. However, whether such variants modulate responses to dib
Externí odkaz:
https://doaj.org/article/b68df42a54c3478aac04f4e497660015
Autor:
Chaini Konwar, Rebecca Asiimwe, Amy M. Inkster, Sarah M. Merrill, Gian L. Negri, Maria J. Aristizabal, Christopher F. Rider, Julie L. MacIsaac, Christopher Carlsten, Michael S. Kobor
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-18 (2021)
Abstract Background Understanding the molecular basis of susceptibility factors to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global health imperative. It is well-established that males are more likely to acquire
Externí odkaz:
https://doaj.org/article/eb8dddcdb6ed41d08f9b4f0c914873af
Autor:
Hannah-Ruth Engelbrecht, Sarah M. Merrill, Nicole Gladish, Julie L. MacIsaac, David T. S. Lin, Simone Ecker, Christina A. Chrysohoou, Giovanni M. Pes, Michael S. Kobor, David H. Rehkopf
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Sex differences in aging manifest in disparities in disease prevalence, physical health, and lifespan, where women tend to have greater longevity relative to men. However, in the Mediterranean Blue Zones of Sardinia (Italy) and Ikaria (Greece) are re
Externí odkaz:
https://doaj.org/article/15b9d68d619542e4acf27dbb31cebca9
Autor:
Ana I. Hernandez Cordero, Chen Xi Yang, Xuan Li, Julia Yang, Tawimas Shaipanich, Julie L. MacIsaac, David T. S. Lin, Michael S. Kobor, Steve Horvath, Shu Fan Paul Man, Don D. Sin, Janice M. Leung
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3094 (2022)
One key feature of Chronic Obstructive Pulmonary Disease (COPD) is that its prevalence increases exponentially with age. DNA methylation clocks have become powerful biomarkers to detect accelerated aging in a variety of diseases and can help prognose
Externí odkaz:
https://doaj.org/article/84f73eb940484d68bd8759df675c679c
Autor:
Darina Czamara, Gökçen Eraslan, Christian M. Page, Jari Lahti, Marius Lahti-Pulkkinen, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori, Pia M. Villa, Rebecca M. Reynolds, Wenche Nystad, Siri E. Håberg, Stephanie J. London, Kieran J. O’Donnell, Elika Garg, Michael J. Meaney, Sonja Entringer, Pathik D. Wadhwa, Claudia Buss, Meaghan J. Jones, David T. S. Lin, Julie L. MacIsaac, Michael S. Kobor, Nastassja Koen, Heather J. Zar, Karestan C. Koenen, Shareefa Dalvie, Dan J. Stein, Ivan Kondofersky, Nikola S. Müller, Fabian J. Theis, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Katri Räikkönen, Elisabeth B. Binder
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Environmental influences during prenatal development may have implications for health and disease later in life. Here, Czamara et al. assess DNA methylation in cord blood from new-born under various models including environmental and genetic effects
Externí odkaz:
https://doaj.org/article/c16c2e7cc35f40888a47624f500c9455
Autor:
Shantala A. Hari Dass, Kathryn McCracken, Irina Pokhvisneva, Lawrence M. Chen, Elika Garg, Thao T.T. Nguyen, Zihan Wang, Barbara Barth, Moein Yaqubi, Lisa M. McEwen, Julie L. MacIsaac, Josie Diorio, Michael S. Kobor, Kieran J. O'Donnell, Michael J. Meaney, Patricia P. Silveira
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 188-202 (2019)
Background: Activation of brain insulin receptors modulates reward sensitivity, inhibitory control and memory. Variations in the functioning of this mechanism likely associate with individual differences in the risk for related mental disorders (atte
Externí odkaz:
https://doaj.org/article/0a930b227bbe495788b5d17b8ed4a14e
Autor:
Calen P. Ryan, Raviraj J. Rege, Nanette R. Lee, Delia B. Carba, Michael S. Kobor, Julie L. MacIsaac, David S. Lin, Parmida Atashzay, Christopher W. Kuzawa
Publikováno v:
Clinical epigenetics. 14(1)
Adverse birth outcomes, such as early gestational age and low birth weight, can have lasting effects on morbidity and mortality, with impacts that persist into adulthood. Identifying the maternal factors that contribute to adverse birth outcomes in t