Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Julie L. H. Madsen"'
Autor:
Michael Bæk, Pablo Martín-Gago, Jonas S. Laursen, Julie L. H. Madsen, Saswati Chakladar, Christian Adam Olsen
Posttranslational modifications (PTMs) are important in the regulation of protein function, trafficking, localization, and marking for degradation. Here, we describe development of peptide activity-based probes for the discovery of proteins that reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3afe0d534fee182403b49e304dd331
https://doi.org/10.26434/chemrxiv.10315502.v1
https://doi.org/10.26434/chemrxiv.10315502.v1
Autor:
Daniel E. Otzen, Troels Skrydstrup, Brian S. Vad, Claudia U. Hjørringgaard, Julie L. H. Madsen
Publikováno v:
Madsen, J L H, Hjørringgaard, C U, Vad, B S, Otzen, D & Skrydstrup, T 2016, ' Incorporation of β-Silicon-β3-Amino Acids in the Antimicrobial Peptide Alamethicin Provides a 20-Fold Increase in Membrane Permeabilization ', Chemistry: A European Journal, vol. 22, no. 24, pp. 8358-8367 . https://doi.org/10.1002/chem.201600445
Incorporation of silicon-containing amino acids in peptides is known to endow the peptide with desirable properties such as improved proteolytic stability and increased lipophilicity. In the presented study, we demonstrate that incorporation of β-si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb980e156c3e508d8529b15f88e880c
https://doi.org/10.1002/chem.201600445
https://doi.org/10.1002/chem.201600445
Autor:
Jan J. Enghild, Troels Skrydstrup, Julie L. H. Madsen, Hideaki Nagase, Salvatore Santamaria, Thomas Levin Andersen
Publikováno v:
Madsen, J L H, Andersen, T L, Santamaria, S, Nagase, H, Enghild, J J & Skrydstrup, T 2012, ' Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase ', Journal of Medicinal Chemistry, vol. 55, no. 17, pp. 7900-7908 . https://doi.org/10.1021/jm301000k
Chronic obstructive pulmonary disease (COPD) is an increasing health problem and is estimated to be the fifth leading cause of death in 2020 according to the World Health Organization. Current treatments are only palliative, and therefore the develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05c845162522ce4df016b410522ca14
https://doi.org/10.1021/jm301000k
https://doi.org/10.1021/jm301000k
Publikováno v:
Kramer, S, Madsen, J L H, Rottländer, M & Skrydstrup, T 2010, ' Access to 2,5-diamidopyrroles and 2,5-diamidofurans by Au(I)-catalyzed double hydroamination or hydration of 1,3-diynes ', Organic Letters, vol. 12, no. 12, pp. 2758-2761 . https://doi.org/10.1021/ol1008685
A Au(I)-catalyzed hydroamination or hydration of 1,3-diynes to access 2,5-diamidopyrroles and 2,5-diamidofurans has been developed. This method can also be expanded to 2,5-disubstituted furans and 1,2,5-trisubstituted pyrroles including the formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5671a14aaaab073444bc60fc7a63c221
https://doi.org/10.1021/ol1008685
https://doi.org/10.1021/ol1008685
Publikováno v:
ChemInform. 41
A variety of 2,5-diamido-pyrroles and furans is prepared starting from the bisacetylenes and anilines or water, respectively [cf.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::056691d86b93e3db9cee0a7c3a45196f
https://doi.org/10.1002/chin.201045103
https://doi.org/10.1002/chin.201045103
Publikováno v:
Organic Letters; Jun2010, Vol. 12 Issue 12, p2758-2761, 4p
Autor:
Bæk, Michael1 (AUTHOR), Martín‐Gago, Pablo1 (AUTHOR), Laursen, Jonas S.1 (AUTHOR), Madsen, Julie L. H.1 (AUTHOR), Chakladar, Saswati1 (AUTHOR), Olsen, Christian A.1 (AUTHOR) cao@sund.ku.dk
Publikováno v:
Chemistry - A European Journal. 3/23/2020, Vol. 26 Issue 17, p3862-3869. 8p.
Autor:
Madsen, Julie L. H.1, Hjørringgaard, Claudia U.1, Vad, Brian S.2, Otzen, Daniel2 dao@inano.au.dk, Skrydstrup, Troels1 ts@chem.au.dk
Publikováno v:
Chemistry - A European Journal. 6/6/2016, Vol. 22 Issue 24, p8358-8367. 10p.