The bloodstream form of Trypanosoma brucei displays non-canonical gluconeogenesis.

Autor: Julie Kovářová, Martin Moos, Michael P Barrett, David Horn, Alena Zíková

Publikováno v: PLoS Neglected Tropical Diseases, Vol 18, Iss 2, p e0012007 (2024)

Trypanosoma brucei is a causative agent of the Human and Animal African Trypanosomiases. The mammalian stage parasites infect various tissues and organs including the bloodstream, central nervous system, skin, adipose tissue and lungs. They rely on A

Externí odkaz: https://doaj.org/article/80c616d10ccd4ebb9a94e244ed85dd6a

Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei.

Autor: Julie Kovářová, Rupa Nagar, Joana Faria, Michael A J Ferguson, Michael P Barrett, David Horn

Publikováno v: PLoS Pathogens, Vol 14, Iss 12, p e1007475 (2018)

Bloodstream form African trypanosomes are thought to rely exclusively upon glycolysis, using glucose as a substrate, for ATP production. Indeed, the pathway has long been considered a potential therapeutic target to tackle the devastating and neglect

Externí odkaz: https://doaj.org/article/8a37953a883343ceacf241b7314b627f

Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana.

Autor: Roy Mwenechanya, Julie Kovářová, Nicholas J Dickens, Manikhandan Mudaliar, Pawel Herzyk, Isabel M Vincent, Stefan K Weidt, Karl E Burgess, Richard J S Burchmore, Andrew W Pountain, Terry K Smith, Darren J Creek, Dong-Hyun Kim, Galina I Lepesheva, Michael P Barrett

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005649 (2017)

Amphotericin B has emerged as the therapy of choice for use against the leishmaniases. Administration of the drug in its liposomal formulation as a single injection is being promoted in a campaign to bring the leishmaniases under control. Understandi

Externí odkaz: https://doaj.org/article/6745f44e729541bfb242217950694ec9

Roles of the Nfu Fe–S targeting factors in the trypanosome mitochondrion

Autor: Ivica Králová-Hromadová, Julius Lukeš, Antonio J. Pierik, Corinna Benz, Julie Kovářová

Publikováno v: International Journal for Parasitology. 46:641-651

Iron-sulphur clusters (ISCs) are protein co-factors essential for a wide range of cellular functions. The core iron-sulphur cluster assembly machinery resides in the mitochondrion, yet due to export of an essential precursor from the organelle, it is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36831dcaca1ea3e906200cac7049193f
https://doi.org/10.1016/j.ijpara.2016.04.006

Aerobic kinetoplastid flagellate Phytomonas does not require heme for viability

Autor: Anton Horváth, Pavel Flegontov, Roman Sobotka, Francisco J. Ayala, Anna Gnipová, Julius Lukeš, Luděk Kořený, Miroslav Oborník, Julie Kovářová

Publikováno v: Kořený, L; Sobotka, R; Kovářová, J; Gnipová, A; Flegontov, P; Horváth, A; et al.(2012). Aerobic kinetoplastid flagellate Phytomonas does not require heme for viability. Proceedings of the National Academy of Sciences of the United States of America, 109(10), 3808-3813. doi: 10.1073/pnas.1201089109. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4d39w5gd

Heme is an iron-coordinated porphyrin that is universally essential as a protein cofactor for fundamental cellular processes, such as electron transport in the respiratory chain, oxidative stress response, or redox reactions in various metabolic path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c250646dbad4b066e4d7a9f08a89e1
https://doi.org/10.1073/pnas.1201089109