Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Julie Kerr‐Conte"'
Autor:
Federica Cuozzo, Katrina Viloria, Ali H. Shilleh, Daniela Nasteska, Charlotte Frazer-Morris, Jason Tong, Zicong Jiao, Adam Boufersaoui, Bryan Marzullo, Daniel B. Rosoff, Hannah R. Smith, Caroline Bonner, Julie Kerr-Conte, Francois Pattou, Rita Nano, Lorenzo Piemonti, Paul R.V. Johnson, Rebecca Spiers, Jennie Roberts, Gareth G. Lavery, Anne Clark, Carlo D.L. Ceresa, David W. Ray, Leanne Hodson, Amy P. Davies, Guy A. Rutter, Masaya Oshima, Raphaël Scharfmann, Matthew J. Merrins, Ildem Akerman, Daniel A. Tennant, Christian Ludwig, David J. Hodson
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114047- (2024)
Summary: Using 13C6 glucose labeling coupled to gas chromatography-mass spectrometry and 2D 1H-13C heteronuclear single quantum coherence NMR spectroscopy, we have obtained a comparative high-resolution map of glucose fate underpinning β cell functi
Externí odkaz:
https://doaj.org/article/2e924f2360b54e9dbc6f6da13e566a04
Autor:
Weidong Zhang, Ayako Miura, Md Moin Abu Saleh, Koichiro Shimizu, Yuichiro Mita, Ryota Tanida, Satoshi Hirako, Seiji Shioda, Valery Gmyr, Julie Kerr-Conte, Francois Pattou, Chunhuan Jin, Yoshikatsu Kanai, Kazuki Sasaki, Naoto Minamino, Hideyuki Sakoda, Masamitsu Nakazato
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Insulin secretion from pancreatic β cells is regulated by multiple stimuli, including nutrients, hormones, neuronal inputs, and local signalling. Amino acids modulate insulin secretion via amino acid transporters expressed on β cells. The
Externí odkaz:
https://doaj.org/article/13b28fe0aa5b471fb9ba3b62af44728f
Autor:
Fabian Wirth, Fabrice D. Heitz, Christine Seeger, Ioana Combaluzier, Karin Breu, Heather C. Denroche, Julien Thevenet, Melania Osto, Paolo Arosio, Julie Kerr-Conte, C. Bruce Verchere, François Pattou, Thomas A. Lutz, Marc Y. Donath, Christoph Hock, Roger M. Nitsch, Jan Grimm
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract In patients with type 2 diabetes, pancreatic beta cells progressively degenerate and gradually lose their ability to produce insulin and regulate blood glucose. Beta cell dysfunction and loss is associated with an accumulation of aggregated
Externí odkaz:
https://doaj.org/article/68eb80d31bdf42208e648a12724a93bf
Autor:
Mikael Chetboun, Christophe Masset, Mehdi Maanaoui, Frédérique Defrance, Valéry Gmyr, Violeta Raverdy, Thomas Hubert, Caroline Bonner, Lisa Supiot, Clarisse Kerleau, Gilles Blancho, Julien Branchereau, Georges Karam, Ismaël Chelghaf, Aurélie Houzet, Magali Giral, Claire Garandeau, Jacques Dantal, Kristell Le Mapihan, Arnaud Jannin, Marc Hazzan, Robert Caiazzo, Julie Kerr-Conte, Marie-Christine Vantyghem, Diego Cantarovich, François Pattou
Publikováno v:
Transplant International, Vol 36 (2023)
In islet transplantation (ITx), primary graft function (PGF) or beta cell function measured early after last infusion is closely associated with long term clinical outcomes. We investigated the association between PGF and 5 year insulin independence
Externí odkaz:
https://doaj.org/article/de1ea47d87a44a57b986f55e27ec6ea1
Autor:
Lorenzo Piemonti, Hanne Scholz, Dide de Jongh, Julie Kerr-Conte, Aart van Apeldoorn, James A. M. Shaw, Marten A. Engelse, Eline Bunnik, Markus Mühlemann, Karolina Pal-Kutas, William E. Scott, Jérémy Magalon, Patrick Kugelmeier, Ekaterine Berishvili
Publikováno v:
Transplant International, Vol 36 (2023)
The field of transplantation has witnessed the emergence of Advanced Therapy Medicinal Products (ATMPs) as highly promising solutions to address the challenges associated with organ and tissue transplantation. ATMPs encompass gene therapy, cell thera
Externí odkaz:
https://doaj.org/article/f85f617a2a2a4eaab2738829f02cdb81
Autor:
Frédérik Oger, Maeva Moreno, Mehdi Derhourhi, Bryan Thiroux, Lionel Berberian, Cyril Bourouh, Emmanuelle Durand, Souhila Amanzougarene, Alaa Badreddine, Etienne Blanc, Olivier Molendi-Coste, Laurent Pineau, Gianni Pasquetti, Laure Rolland, Charlène Carney, Florine Bornaque, Emilie Courty, Céline Gheeraert, Jérôme Eeckhoute, David Dombrowicz, Julie Kerr-Conte, François Pattou, Bart Staels, Philippe Froguel, Amélie Bonnefond, Jean-Sébastien Annicotte
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107231- (2023)
Summary: Histone deacetylases enzymes (HDACs) are chromatin modifiers that regulate gene expression through deacetylation of lysine residues within specific histone and non-histone proteins. A cell-specific gene expression pattern defines the identit
Externí odkaz:
https://doaj.org/article/75620a5d73cf44908a7169d2d5030f87
Autor:
Rébecca Goutchtat, Audrey Quenon, Manon Clarisse, Nathalie Delalleau, Anaïs Coddeville, Mathilde Gobert, Valéry Gmyr, Julie Kerr‐Conte, François Pattou, Thomas Hubert
Publikováno v:
Endocrinology, Diabetes & Metabolism, Vol 6, Iss 4, Pp n/a-n/a (2023)
Abstract Introduction Nowadays, there are no strong diabetic pig models, yet they are required for various types of diabetes research. Using cutting‐edge techniques, we attempted to develop a type 2 diabetic minipig model in this study by combining
Externí odkaz:
https://doaj.org/article/6c47b3bb4b4d49faa4f6f4f60ff4da2e
Autor:
Goutham Atla, Silvia Bonàs-Guarch, Mirabai Cuenca-Ardura, Anthony Beucher, Daniel J. M. Crouch, Javier Garcia-Hurtado, Ignasi Moran, the T2DSystems Consortium, Manuel Irimia, Rashmi B. Prasad, Anna L. Gloyn, Lorella Marselli, Mara Suleiman, Thierry Berney, Eelco J. P. de Koning, Julie Kerr-Conte, Francois Pattou, John A. Todd, Lorenzo Piemonti, Jorge Ferrer
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-28 (2022)
Abstract Background Non-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely also contribute to type 1 diabetes (T1D) risk. For many loci, however,
Externí odkaz:
https://doaj.org/article/cf1281e02aac42cea7c15b4711ce5611
Autor:
Mehdi Maanaoui, Mikael Chetboun, Isabelle Top, Vincent Elsermans, Julie Kerr-Conte, Kristell Le Mapihan, Frederique Defrance, Valéry Gmyr, Thomas Hubert, Myriam Labalette, Marc Hazzan, Marie-Christine Vantyghem, François Pattou
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Islet transplantation is a unique paradigm in organ transplantation, since multiple donors are required to achieve complete insulin-independence. Preformed or de novo Donor Specific Antibodies (DSA) may target one or several donor islets, wh
Externí odkaz:
https://doaj.org/article/26072c48556343349914000b9f0a5ade
Autor:
Lorea Zubiaga, Olivier Briand, Florent Auger, Veronique Touche, Thomas Hubert, Julien Thevenet, Camille Marciniak, Audrey Quenon, Caroline Bonner, Simon Peschard, Violeta Raverdy, Mehdi Daoudi, Julie Kerr-Conte, Gianni Pasquetti, Hermann Koepsell, Daniela Zdzieblo, Markus Mühlemann, Bernard Thorens, Nathalie D. Delzenne, Laure B. Bindels, Benoit Deprez, Marie C. Vantyghem, Blandine Laferrère, Bart Staels, Damien Huglo, Sophie Lestavel, François Pattou
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106057- (2023)
Summary: Metformin (MET) is the most prescribed antidiabetic drug, but its mechanisms of action remain elusive. Recent data point to the gut as MET’s primary target. Here, we explored the effect of MET on the gut glucose transport machinery. Using
Externí odkaz:
https://doaj.org/article/a2d8b736d8cd49a09e2f84d1fd3fac11