Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Julie K.-L. Sinclair"'
Publikováno v:
Biochemistry. 60:500-512
We previously reported a family of hydrocarbon-stapled peptides designed to interact with the epidermal growth factor receptor (EGFR) juxtamembrane (JM) segment, blocking its ability to form a coiled coil dimer that is essential for receptor activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b121cadeb61cffd1c519f1feb08501c
https://doi.org/10.1021/acs.biochem.0c00978
https://doi.org/10.1021/acs.biochem.0c00978
Autor:
Julie K.-L. Sinclair, Alanna Schepartz
Publikováno v:
Organic letters, vol 16, iss 18
Organic Letters
Organic Letters
The hydrocarbon-stapled peptide E1(S) allosterically inhibits the kinase activity of the epidermal growth factor receptor (EGFR) by blocking a distant but essential protein-protein interaction: a coiled coil formed from the juxtamembrane segment (JM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7450bf006a13e8327996dc5e2a1c721
https://doi.org/10.1021/ol502426b
https://doi.org/10.1021/ol502426b
Publikováno v:
Cell chemical biology, vol 25, iss 7
Epidermal growth factor receptor (EGFR) interacts through its extracellular domain with seven different growth factors. These factors induce different structures within the cytoplasmic juxtamembrane (JM) segment of the dimeric receptor and propagate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03fb90abb8cc21f0ebed64a95e2755a5
https://doi.org/10.1016/j.chembiol.2018.04.005
https://doi.org/10.1016/j.chembiol.2018.04.005
Publikováno v:
Journal of the American Chemical Society, vol 136, iss 32
Journal of the American Chemical Society
Journal of the American Chemical Society
The epidermal growth factor receptor (EGFR) tyrosine kinase is implicated in a large number of human cancers. Most EGFR inhibitors target the extracellular, growth factor-binding domain or the intracellular, ATP-binding domain. Here we describe molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a139e50b399042cd444d73057c02ef6
https://escholarship.org/uc/item/1kt600bq
https://escholarship.org/uc/item/1kt600bq
