Výsledky vyhledávání - "Julie K. Hicks"

Divergence of Protein Kinase A Catalytic Subunits in Cryptococcus neoformans and Cryptococcus gattii Illustrates Evolutionary Reconfiguration of a Signaling Cascade

Autor: Julie K. Hicks, Joseph Heitman

Publikováno v: Eukaryotic Cell. 6:413-420

Gene duplication and divergence via both the loss and gain of gene activities are powerful evolutionary forces underlying the origin of new biological functions. Here a comparative genetics approach was applied to examine the roles of protein kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850ad09e0f7ce233cea6d3ab2268717a
https://doi.org/10.1128/ec.00213-06

Zobrazit plný text záznamu

RcoA has pleiotropic effects on Aspergillus nidulans cellular development

Autor: Nancy P. Keller, Daniel Dieringer, Joan M. Kelly, Joseph Strauss, Julie K. Hicks, Robin Lockington, Christian P. Kubicek

Publikováno v: Molecular Microbiology. 39:1482-1493

Aspergillus nidulans rcoA encodes a member of the WD repeat family of proteins. The RcoA protein shares sequence similarity with other members of this protein family, including the Saccharomyces cerevisiae Tup1p and Neurospora crassa RCO1. Tup1p is i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f5875c03d5e275c56d13c4da5100b2
https://doi.org/10.1046/j.1365-2958.2001.02332.x

Zobrazit plný text záznamu

G-protein signalling mediates differential production of toxic secondary metabolites

Autor: Gulnara F. Garifullina, Nancy P. Keller, Marian N. Beremand, Andrew G. Tag, Timothy D. Phillips, C. L. Ake, Julie K. Hicks

Publikováno v: Molecular Microbiology. 38:658-665

Filamentous fungi elaborate a complex array of secondary metabolites, including antibiotics and mycotoxins. As many of these compounds pose significant economic and health concerns, elucidation of the underlying cellular mechanisms that control their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f63e8502bb54aee4c65861e7b4f356
https://doi.org/10.1046/j.1365-2958.2000.02166.x

Zobrazit plný text záznamu

Pde1 Phosphodiesterase Modulates Cyclic AMP Levels through a Protein Kinase A-Mediated Negative Feedback Loop in Cryptococcus neoformans

Autor: Joseph Heitman, Julie K. Hicks, Yong Sun Bahn

The virulence of the human pathogenic fungus Cryptococcus neoformans is regulated by a cyclic AMP (cAMP)-dependent protein kinase A (PKA) signaling cascade that promotes mating and the production of melanin and capsule. In this study, genes encoding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969b13048cbc92ef8794a859ad71090e
https://europepmc.org/articles/PMC1317495/

Zobrazit plný text záznamu

Adenylyl Cyclase-Associated Protein Aca1 Regulates Virulence and Differentiation of Cryptococcus neoformans via the Cyclic AMP-Protein Kinase A Cascade†

Autor: Gary M. Cox, Joseph Heitman, Yong Sun Bahn, Steven S. Giles, Julie K. Hicks

The evolutionarily conserved cyclic AMP (cAMP) signaling pathway controls cell functions in response to environmental cues in organisms as diverse as yeast and mammals. In the basidiomycetous human pathogenic fungus Cryptococcus neoformans , the cAMP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7526a1813b1822ef4eb67cd01314272b
https://europepmc.org/articles/PMC539029/

Zobrazit plný text záznamu

Cyclic AMP-Dependent Protein Kinase Catalytic Subunits Have Divergent Roles in Virulence Factor Production in Two Varieties of the Fungal Pathogen Cryptococcus neoformans

Autor: Julie K. Hicks, Cletus D'Souza, Joseph Heitman, Gary M. Cox

Our earlier findings established that cyclic AMP-dependent protein kinase functions in a signaling cascade that regulates mating and virulence of Cryptococcus neoformans var. grubii (serotype A). Mutants lacking the serotype A protein kinase A (PKA)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4026b5aab06f096532be92ac5e570db3
https://europepmc.org/articles/PMC329511/

Zobrazit plný text záznamu

Pka, Ras and RGS protein interactions regulate activity of AflR, a Zn(II)2Cys6 transcription factor in Aspergillus nidulans

Autor: Nancy P. Keller, Kiminori Shimizu, Julie K. Hicks, Tzu Pi Huang

Sterigmatocystin (ST) is a carcinogenic polyketide produced by several filamentous fungi including Aspergillus nidulans. Expression of ST biosynthetic genes (stc genes) requires activity of a Zn(II)2Cys6 transcription factor, AflR. aflR is transcript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d005b38eabe82f3849b77fff376656fb
https://europepmc.org/articles/PMC1462812/

Zobrazit plný text záznamu

Genetics and Biosynthesis of Aflatoxins and Sterigmatocystin

Autor: Nancy P. Keller, Julie K. Hicks, Kiminori Shimizu

Publikováno v: Agricultural Applications ISBN: 9783642076503

Many microorganisms produce low molecular weight compounds called secondary metabolites whose benefit to the producing organism is often obscure (Bu’Lock 1961). Fungi are among the most prodigious producers of secondary metabolites, many of which a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4511564af71274a8e959748806e27fa5
https://doi.org/10.1007/978-3-662-03059-2_4

Zobrazit plný text záznamu

Aspergillus sporulation and mycotoxin production both require inactivation of the FadA G alpha protein-dependent signaling pathway

Autor: Thomas H. Adams, Nancy P. Keller, Jae-Hyuk Yu, Julie K. Hicks

Publikováno v: The EMBO journal. 16(16)

The filamentous fungus Aspergillus nidulans contains a cluster of 25 genes that encode enzymes required to synthesize a toxic and carcinogenic secondary metabolite called sterigmatocystin (ST), a precursor of the better known fungal toxin aflatoxin (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e08a712ff0c951592afa0c046fcd0f7
https://pubmed.ncbi.nlm.nih.gov/9305634

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání