Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Julie K. Brooks"'
Autor:
Jennifer L. Cotton, Julie K. Brooks, Mihir Rajurkar, Andrew P. McMahon, He Huang, Junhao Mao, Jason K. Sicklick
Publikováno v:
Oncogene. 33:5370-5378
Dysregulation of the Hedgehog (Hh)-Gli signaling pathway is implicated in a variety of human cancers, including basal cell carcinoma (BCC), medulloblastoma (MB) and embryonal rhabdhomyosarcoma (eRMS), three principle tumors associated with human Gorl
Autor:
Andrew L. Frelinger, Alan D. Michelson, Joseph A. Jakubowski, Julie K. Brooks, Sabrina L. Zayas, Matthew M. Heeney, Michelle A. Berny-Lang, Marc R. Barnard
Publikováno v:
Platelets. 25:27-35
Abstract 5147 Platelet activation/aggregation in sickle cell disease (SCD) may promote tissue ischemia, suggesting antiplatelet therapy may be useful. However, assessing platelet function and the effect of antiplatelet therapy in blood from SCD patie
Autor:
Sai Nudurupati, Andrew L. Frelinger, Julie K. Brooks, Jingtao Wu, Ronald D. Lee, Michael Lampa, Anu Nigam, Marc R. Barnard, Darcy Mulford, Deepak L. Bhatt, Alan D. Michelson
Publikováno v:
Journal of the American College of Cardiology. 61:872-879
Abstract 4356 Background: Platelet inhibition by clopidogrel is highly variable. Patients with reduced inhibition have increased risk for major adverse cardiovascular events. The aim of this study was to determine whether known genetic, drug, dietary
Autor:
Julie K. Brooks, Alan D. Michelson, Anu Nigam, Michelle A. Berny-Lang, Marc R. Barnard, Andrew L. Frelinger, Matthew M. Heeney, Joseph A. Jakubowski
Publikováno v:
Blood. 118:2141-2141
Abstract 2141 Introduction: In patients with sickle cell disease (SCD), erythrocytes contribute to microvessel occlusion resulting in tissue damage and platelet activation. Platelet activation, aggregation, local thrombus formation and platelet activ
Autor:
Andrew L. Frelinger, Jingtao Wu, Sai Nudurupati, Anu Nigam, Julie K. Brooks, Ronald D. Lee, Darcy Mulford, Deepak L. Bhatt, Alan D. Michelson
Publikováno v:
Journal of the American College of Cardiology. (14):1304-1311
Objectives The aim of this study was to assess the effects of different proton pump inhibitors (PPIs) on the steady-state pharmacokinetics and pharmacodynamics of clopidogrel. Background Metabolism of clopidogrel requires cytochrome P450s (CYPs), inc