Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Julie K. Andersen"'
Autor:
Kristen M. C. Malecki, Julie K. Andersen, Andrew M. Geller, G. Jean Harry, Chandra L. Jackson, Katherine A. James, Gary W. Miller, Mary Ann Ottinger
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Despite significant overlaps in mission, the fields of environmental health sciences and aging biology are just beginning to intersect. It is increasingly clear that genetics alone does not predict an individual’s neurological aging and sensitivity
Externí odkaz:
https://doaj.org/article/168bd5fbdd3144d688eee1a6a51b39b4
Autor:
Nikhita Anand, Angelina Holcom, Michael Broussalian, Minna Schmidt, Shankar J. Chinta, Gordon J. Lithgow, Julie K. Andersen, Manish Chamoli
Publikováno v:
Neurobiology of Disease, Vol 139, Iss , Pp 104786- (2020)
Mutations in the human ATP13A2 gene are associated with an early-onset form of Parkinson's disease (PD) known as Kufor Rakeb Syndrome (KRS). Patients with KRS show increased iron deposition in the basal ganglia, suggesting iron toxicity-induced neuro
Externí odkaz:
https://doaj.org/article/960f8ce2435743688e358ea2dfa5510f
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Due to their postmitotic status, the potential for neurons to undergo senescence has historically received little attention. This lack of attention has extended to some non-postmitotic cells as well. Recently, the study of senescence within the centr
Externí odkaz:
https://doaj.org/article/3b95e011dd1943e397a1b408b0eb96ff
Autor:
Shankar J. Chinta, Georgia Woods, Marco Demaria, Anand Rane, Ying Zou, Amanda McQuade, Subramanian Rajagopalan, Chandani Limbad, David T. Madden, Judith Campisi, Julie K. Andersen
Publikováno v:
Cell Reports, Vol 22, Iss 4, Pp 930-940 (2018)
Exposure to the herbicide paraquat (PQ) is associated with an increased risk of idiopathic Parkinson’s disease (PD). Therapies based on PQ’s presumed mechanisms of action have not, however, yielded effective disease therapies. Cellular senescence
Externí odkaz:
https://doaj.org/article/a50111f1811844c78146b1804f884ac5
Autor:
Dinesh Kumar Verma, Bo Am Seo, Anurupa Ghosh, Shi-Xun Ma, Karina Hernandez-Quijada, Julie K. Andersen, Han Seok Ko, Yong-Hwan Kim
Publikováno v:
Cells, Vol 10, Iss 7, p 1694 (2021)
Emerging evidence indicates that cellular senescence could be a critical inducing factor for aging-associated neurodegenerative disorders. However, the involvement of cellular senescence remains unclear in Parkinson’s disease (PD). To determine thi
Externí odkaz:
https://doaj.org/article/6530750c1f074ad4bfd5d398e34b4d60
Publikováno v:
Neurobiology of Disease, Vol 93, Iss , Pp 115-120 (2016)
Loss of parkin E3 ligase activity as a result of parkin gene mutation in rare familial forms of Parkinson's disease (PD) has been shown to be detrimental to mitochondrial function and to contribute to ensuing neurodegeneration. This has been shown by
Externí odkaz:
https://doaj.org/article/fd227dde9da846269de2ecaa1f8d1172
Autor:
Dmitri Leonoudakis, Anand Rane, Suzanne Angeli, Gordon J. Lithgow, Julie K. Andersen, Shankar J. Chinta
Publikováno v:
Mediators of Inflammation, Vol 2017 (2017)
Glial activation and subsequent release of neurotoxic proinflammatory factors are believed to play an important role in the pathogenesis of several neurological disorders including Parkinson’s disease (PD). Inhibition of glial activation and inflam
Externí odkaz:
https://doaj.org/article/e8297fd24b1748928399fffe66af1127
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 2, Pp 527-532 (2011)
We previously demonstrated that elevation of astrocytic monoamine oxidase B (MAO-B) levels in a doxycycline (dox)-inducible transgenic mouse model following 14 days of dox induction results in several neuropathologic features similar to those observe
Externí odkaz:
https://doaj.org/article/4caeb220f4bc40ec8bf4d585c9c26a38
Publikováno v:
Neurobiology of Disease, Vol 40, Iss 2, Pp 444-448 (2010)
We previously demonstrated that elevation of astrocytic monoamine oxidase B (MAO-B) levels in a doxycycline (dox)-inducible transgenic mouse model following 14 days of dox induction results in several neuropathologic features similar to those observe
Externí odkaz:
https://doaj.org/article/1dc1a0e789444e4e87db97fe7acbd9a5
Autor:
Wen Zhu, Xuping Li, Wenjie Xie, Feifei Luo, Deepinder Kaur, Julie K. Andersen, Joseph Jankovic, Weidong Le
Publikováno v:
Neurobiology of Disease, Vol 37, Iss 2, Pp 307-313 (2010)
Impairment of the ubiquitin proteasome system (UPS) and iron accumulation in the substantia nigra (SN) have both been implicated in the pathogenesis of Parkinson's disease (PD). We previously reported that chemical iron chelation can protect against
Externí odkaz:
https://doaj.org/article/711953f88d5a484898f1a74681063fb1