Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Julie K Horton"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Oxidative stress in cells leads to the oxidations of DNA precursors. Here the authors show that these oxidized precursors can be incorporatedin vivoduring base excision repair, leading to DNA breaks and cytotoxicity.
Externí odkaz:
https://doaj.org/article/d2a81dca650b43be9b6e7c1748afddde
Autor:
Samuel H. Wilson, Padmini S. Kedar, Natalie R. Gassman, Rajendra Prasad, Donna F. Stefanick, Julie K. Horton
PDF file - 422KB, S1. Cell survival as measured by a clonogenic assay. S2. BRCT I domain of XRCC1. S3. Characterization of cell lines by western blotting. S4. Characterization of full-length wild-type XRCC1 and L360R mutant XRCC1 mouse proteins. S5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7400420d7d6dfc6266f20035e720ae73
https://doi.org/10.1158/1541-7786.22513761
https://doi.org/10.1158/1541-7786.22513761
Autor:
Zhongliang Jiang, Yanhao Lai, Jill M. Beaver, Pawlos S. Tsegay, Ming-Lang Zhao, Julie K. Horton, Marco Zamora, Hayley L. Rein, Frank Miralles, Mohammad Shaver, Joshua D. Hutcheson, Irina Agoulnik, Samuel H. Wilson, Yuan Liu
Publikováno v:
Cells, Vol 9, Iss 1, p 225 (2020)
DNA damage and base excision repair (BER) are actively involved in the modulation of DNA methylation and demethylation. However, the underlying molecular mechanisms remain unclear. In this study, we seek to understand the mechanisms by exploring the
Externí odkaz:
https://doaj.org/article/788c11cb8b9c443193a8998431ba13e9
Autor:
Ming-Lang Zhao, Donna F. Stefanick, Cristina A. Nadalutti, William A. Beard, Samuel H. Wilson, Julie K. Horton
Publikováno v:
DNA Repair. 126:103486
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bab50c32d3d5c48f011e212c2828a45
https://doi.org/10.1016/j.dnarep.2023.103486
https://doi.org/10.1016/j.dnarep.2023.103486
Publikováno v:
J Biol Chem
DNA polymerase (pol) β catalyzes two reactions at DNA gaps generated during base excision repair, gap-filling DNA synthesis and lyase-dependent 5´-end deoxyribose phosphate removal. The lyase domain of pol β has been proposed to function in DNA ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91facac33bbf974c03ed0f6138b7c2c9
https://doi.org/10.1074/jbc.ra120.013547
https://doi.org/10.1074/jbc.ra120.013547
Autor:
Cristina A. Nadalutti, Julie K. Horton, Donna F. Stefanick, Ashley M. Brooks, Rajendra Prasad, Ming-Lang Zhao, Jack D. Griffith, Samuel H. Wilson
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Formaldehyde (FA) is a simple biological aldehyde that is produced inside cells by several processes such as demethylation of DNA and proteins, amino acid metabolism, lipid peroxidation and one carbon metabolism (1-C). Although accumulation of excess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f68b1e501850466295b111722b6758c
http://link.springer.com/article/10.1038/s41598-020-61477-2
http://link.springer.com/article/10.1038/s41598-020-61477-2
Autor:
Natalie R Gassman, Erdem Coskun, Donna F Stefanick, Julie K Horton, Pawel Jaruga, Miral Dizdaroglu, Samuel H Wilson
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118819 (2015)
Bisphenol A (BPA) is a biologically active industrial chemical used in production of consumer products. BPA has become a target of intense public scrutiny following concerns about its association with human diseases such as obesity, diabetes, reprodu
Externí odkaz:
https://doaj.org/article/8502575a8e19401384acb98b88b2745d
Autor:
Julie K, Horton, Agnes K, Janoshazi, Cristina A, Nadalutti, Ming-Lang, Zhao, Donna F, Stefanick, Samuel H, Wilson
Publikováno v:
DNA Repair. 116:103357
Mouse fibroblasts lacking (null) DNA polymerase β (pol β) were transfected with fluorescently tagged pol β and stained with biomarkers to allow visualization within living cells by confocal microscopy. Transient transfection resulted in varying po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7468bbe567b3d8e6f26b86b55c20898e
https://doi.org/10.1016/j.dnarep.2022.103357
https://doi.org/10.1016/j.dnarep.2022.103357
Publikováno v:
DNA Repair. 114:103322
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f5225278bb1ab51223465edbc38a863
https://doi.org/10.1016/j.dnarep.2022.103322
https://doi.org/10.1016/j.dnarep.2022.103322
Autor:
Julie K. Horton, Samuel H. Wilson
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
PARP inhibitors (PARPi) are under clinical trial for combination cancer chemotherapy. In the presence of a PARPi, PARP-1 binds DNA strand breaks but cannot produce poly(ADP-ribose) polymers or undergo auto-poly(ADP-ribosyl)ation. DNA binding is persi
Externí odkaz:
https://doaj.org/article/73d759f68f0a49fa863f9553466355ac