Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Julie K Andersen"'
Autor:
Daniel S Evans, Monique N O'Leary, Ryan Murphy, Minna Schmidt, Kristin Koenig, Michael Presley, Brittany Garrett, Ha‐Neui Kim, Li Han, Emmeline C Academia, Matt J Laye, Daniel Edgar, Christopher A Zambataro, Tracey Barhydt, Colleen M Dewey, Jarrott Mayfield, Joy Wilson, Silvestre Alavez, Mark Lucanic, Brian K Kennedy, Maria Almeida, Julie K Andersen, Pankaj Kapahi, Gordon J Lithgow, Simon Melov
Publikováno v:
JBMR Plus, Vol 5, Iss 3, Pp n/a-n/a (2021)
ABSTRACT Aging is characterized by systemic declines in tissue and organ functions. Interventions that slow these declines represent promising therapeutics to protect against age‐related disease and improve the quality of life. In this study, sever
Externí odkaz:
https://doaj.org/article/1488f0e2d6454063828ddeb29690b6a6
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54200 (2013)
We have previously shown that increases in astrocytic monoamine oxidase-B (MAO-B) expression, mimicking that which occurs with aging and in neurodegenerative disease, in a doxycycline (dox)-inducible transgenic mouse model evokes neuropathological si
Externí odkaz:
https://doaj.org/article/fb873e9c2b0d4faaa9b04cce7845cae4
Autor:
Jyothi K Mallajosyula, Deepinder Kaur, Shankar J Chinta, Subramanian Rajagopalan, Anand Rane, David G Nicholls, Donato A Di Monte, Heather Macarthur, Julie K Andersen
Publikováno v:
PLoS ONE, Vol 3, Iss 2, p e1616 (2008)
Age-related increases in monoamine oxidase B (MAO-B) may contribute to neurodegeneration associated with Parkinson's disease (PD). The MAO-B inhibitor deprenyl, a long-standing antiparkinsonian therapy, is currently used clinically in concert with th
Externí odkaz:
https://doaj.org/article/b8482a61d62f4122afaf4ad8c7643b7a
Autor:
Cyrene Arputhasamy, Anna C. Foulger, Mark Lucanic, Anand Rane, Minna Schmidt, Theo Garrett, Michael Broussalian, Elena Battistoni, Rachel B. Brem, Gordon J. Lithgow, Manish Chamoli, Julie K. Andersen
Publikováno v:
GeroScience
Lysosomes are crucial for degradation and recycling of damaged proteins and cellular components. Therapeutic strategies enhancing lysosomal function are a promising approach for aging and age-related neurodegenerative diseases. Here, we show that an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d695f60b6eeea96ebb11d48a0c5d1829
https://doi.org/10.1007/s11357-022-00647-8
https://doi.org/10.1007/s11357-022-00647-8
Background In recent years, a burgeoning body of evidence has pointed to age-related dysfunction in neuronal autophagy as playing a prominent role in neuropathology associated with Alzheimer’s disease (AD). In the present study, we investigated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9daddb63c63be74b18cdac52fd52b7d4
https://doi.org/10.21203/rs.3.rs-2046848/v1
https://doi.org/10.21203/rs.3.rs-2046848/v1
Autor:
Sarah J. Shemtov, Rohini Emani, Olga Bielska, Anthony J. Covarrubias, Eric Verdin, Julie K. Andersen, Daniel A. Winer
Publikováno v:
The FEBS Journal.
Obesity and ageing predispose to numerous, yet overlapping chronic diseases. For example, metabolic abnormalities, including insulin resistance (IR) and type 2 diabetes (T2D) are important causes of morbidity and mortality. Low-grade chronic inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b5024438c7c52c6e0d9757613f6d9a
https://doi.org/10.1111/febs.16558
https://doi.org/10.1111/febs.16558
Autor:
Kristen M C, Malecki, Julie K, Andersen, Andrew M, Geller, G Jean, Harry, Chandra L, Jackson, Katherine A, James, Gary W, Miller, Mary Ann, Ottinger
Publikováno v:
Frontiers in Aging Neuroscience. 14
Despite significant overlaps in mission, the fields of environmental health sciences and aging biology are just beginning to intersect. It is increasingly clear that genetics alone does not predict an individual’s neurological aging and sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae903c9cc9c9fb490eeb4f790f00df6
https://doi.org/10.3389/fnagi.2022.824921
https://doi.org/10.3389/fnagi.2022.824921
Autor:
Gordon J. Lithgow, Michael Broussalian, Anand Rane, Julie K. Andersen, Cyrene Arputhasamy, Theo Garett, Manish Chamoli, Rachel B. Brem, Anna C. Foulger, Elena Battistoni, Minna Schmidt, Mark Lucanic
Lysosomes are crucial for degradation and recycling of damaged proteins and cellular components. Therapeutic strategies enhancing lysosomal function are a promising approach for aging and age-related neurodegenerative diseases. Here, we show that an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77ffafd319382ffd35b193048f2cfb17
https://doi.org/10.1101/2021.10.21.465344
https://doi.org/10.1101/2021.10.21.465344
Autor:
Julie K. Andersen, Alexandra B. Steinberg, Suckwon Lee, Shankar J. Chinta, Chaska C. Walton, Ellen Y. Wang
Publikováno v:
Mech Ageing Dev
Cellular senescence is a potential tumor-suppressive mechanism that generally results in an irreversible cell cycle arrest. Senescent cells accumulate with age and actively secrete soluble factors, collectively termed the 'senescence-associated secre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc696d263b8c856403c8afdacb8f4fb0
https://pubmed.ncbi.nlm.nih.gov/34627838
https://pubmed.ncbi.nlm.nih.gov/34627838
Autor:
Anna C. Foulger, Tanuja Harshani Peiris, Manish Chamoli, Azar Asadi Shahmirzadi, Julie K. Andersen, Gordon J. Lithgow, Akos A. Gerencser, Suzanne Angeli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbfbf02f81a34e3882e87c77b6d69f2d
https://doi.org/10.7554/elife.63453.sa2
https://doi.org/10.7554/elife.63453.sa2