Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Julie Higgins"'
Autor:
Heather L. Martin, Amy L. Turner, Julie Higgins, Anna A. Tang, Christian Tiede, Thomas Taylor, Sitthinon Siripanthong, Thomas L. Adams, Iain W. Manfield, Sandra M. Bell, Ewan E. Morrison, Jacquelyn Bond, Chi H. Trinh, Carolyn D. Hurst, Margaret A. Knowles, Richard W. Bayliss, Darren C. Tomlinson
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113184- (2023)
Summary: Kinases are important therapeutic targets, and their inhibitors are classified according to their mechanism of action, which range from blocking ATP binding to covalent inhibition. Here, a mechanism of inhibition is highlighted by capturing
Externí odkaz:
https://doaj.org/article/602d6e2e2cea4be1917c7c7c7b34ebd6
Publikováno v:
BMJ Open, Vol 11, Iss 11 (2021)
Introduction The short-term economic benefit of embedding best practice tobacco dependence treatment (TDT) into healthcare services prior to surgery across different populations and jurisdictions is largely unknown. The aim of this systematic review
Externí odkaz:
https://doaj.org/article/ab2db95bfe2842748578cbcb5d5a4064
Autor:
Heather L Martin, Matthew Adams, Julie Higgins, Jacquelyn Bond, Ewan E Morrison, Sandra M Bell, Stuart Warriner, Adam Nelson, Darren C Tomlinson
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88338 (2014)
Toxicity is a major cause of failure in drug discovery and development, and whilst robust toxicological testing occurs, efficiency could be improved if compounds with cytotoxic characteristics were identified during primary compound screening. The us
Externí odkaz:
https://doaj.org/article/662c944ba0d54a6e9808ab389a227357
Publikováno v:
Journal of the Australian Library and Information Association. 71:89-107
Autor:
Heather Louise Martin, Amy L. Turner, Julie Higgins, Anna A. Tang, Christian Tiede, Thomas Taylor, Thomas L. Adams, Sandra M. Bell, Ewan E. Morrison, Jacquelyn Bond, Chi H. Trinh, Carolyn D. Hurst, Margaret Knowles, Richard Bayliss, Darren C. Tomlinson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8917ff9c581be0aeeeaa231bf174caa
https://doi.org/10.2139/ssrn.4350139
https://doi.org/10.2139/ssrn.4350139
Autor:
Nikki McCaffrey, Julie Higgins, Elizabeth Greenhalgh, Sarah L. White, Nicholas Graves, Paul S. Myles, John E. Cunningham, Emma Dean, Sally Doncovio, Lisa Briggs, Anita Lal
Publikováno v:
International journal of surgery (London, England). 104
Whilst there is a substantial body of evidence on the costs and benefits of smoking cessation generally, the benefits of routinely providing smoking cessation for surgical populations are less well known. This review summarises the evidence on the co
Autor:
Henry King, Alastair Droop, Ewan E. Morrison, Ruth Morton, Susan C Short, Julie Higgins, Gary Shaw, Peter Laslo, B. da Silva, Euan S. Polson, Lynette Steele, Daniel Tams, Heather L. Martin, Matthew Adams, Heiko Wurdak, Darren C. Tomlinson, Sean E. Lawler, Marjorie Boissinot, Josie Hayes, Jacquelyn Bond, Thomas Ward
Publikováno v:
Oncogene
MicroRNAs play an important role in the regulation of mRNA translation and have therapeutic potential in cancer and other diseases. To profile the landscape of microRNAs with significant cytotoxicity in the context of glioblastoma (GBM), we performed
Publikováno v:
BMJ Open, Vol 11, Iss 11 (2021)
BMJ Open
BMJ Open
IntroductionThe short-term economic benefit of embedding best practice tobacco dependence treatment (TDT) into healthcare services prior to surgery across different populations and jurisdictions is largely unknown. The aim of this systematic review i
Autor:
Thomas Ward, Heiko Wurdak, Barbara da Silva, Daniel Tams, Euan S. Polson, Sean E. Lawler, Jacquelyn Bond, Ewan E. Morrison, Ruth Morton, Julie Higgins, Darren C. Tomlinson, Josie Hayes, Susan C Short, Henry King, Peter Laslo, Heather L. Martin, Lynette Steele, Matthew Adams, Marjorie Boissinot, Alastair Droop
BackgroundMicroRNAs play an important role in the regulation of mRNA translation, and have therapeutic potential in cancer and other diseases.MethodsTo profile the landscape of microRNAs with significant cytotoxicity in the context of glioblastoma (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da0487a4579d34f8508c5faccc92ed2
Autor:
Richard T. Pon, Ryan E. Lamont, Uwe Wolfrum, Robert A. Hegele, Dan Doherty, Fiona Stewart, Martin McKibbin, Jay Shendure, Grischa Toedt, Colin E. Willoughby, Jillian S. Parboosingh, Clem Donahue, Kirsten A. Wunderlich, Lijia Huang, Marius Ueffing, Hannah M. Mitchison, Nasrin Sorusch, Teunis J. P. van Dam, Zakia Abdelhamed, Kym M. Boycott, Francois P. Bernier, Mohammed A. Aldahmesh, Subaashini Natarajan, Bernard N. Chodirker, Carole Ober, Julie Higgins, Matthew Adams, Darren C. Tomlinson, Hilary E. Racher, Thanh Minh T. Nguyen, Ian G. Phelps, Andreas Giessl, Katarzyna Szymanska, Ewan E. Morrison, Albert E. Chudley, Fowzan S. Alkuraya, Panagiotis I. Sergouniotis, Patrick Frosk, Jacquelyn Bond, Miriam Schmidts, Susanne Roosing, Nicola Horn, Gabrielle Wheway, Sandra M. Bell, Carmel Toomes, Toby J. Gibson, Martijn A. Huynen, Philip L. Beales, Gisela G. Slaats, Julie Kennedy, Clare V. Logan, Oliver E. Blacque, Paul M. K. Gordon, Rachel H. Giles, Heymut Omran, Aizeddin A. Mhanni, A. James Barkovich, David A. Parry, A. Micheil Innes, Dorus A. Mans, Jeroen van Reeuwijk, Kristin Kessler, Louis Wolf, Shamsa Anazi, Evan A. Boyle, Karsten Boldt, Ronald Roepman, Joseph G. Gleeson, Andrew R. Webster, Selwa A. Al Hazzaa, Chris F. Inglehearn, Warren Herridge, Christian Thiel, Chandree L. Beaulieu, Colin A. Johnson, Stef J.F. Letteboer
Publikováno v:
Nature cell biology
Nature Cell Biology, 17, 8, pp. 1074-87
Nature Cell Biology, 17, 1074-87
Nature Cell Biology, 17(8), 1074. Nature Publishing Group
Nature Cell Biology, 17, 8, pp. 1074-87
Nature Cell Biology, 17, 1074-87
Nature Cell Biology, 17(8), 1074. Nature Publishing Group
Item does not contain fulltext Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe a whole-genome siRNA-based reverse genetics screen for defects in biogenesis and/or maintenance of the pr