Novel routes to either racemic or enantiopure α-amino-(4-hydroxy-pyrrolidin-3-yl)acetic acid derivatives and biological evaluation of a new promising pharmacological scaffold

Autor: Nathalie Strazielle, Luc Denoroy, Jean-François Ghersi-Egea, Sandrine Blondel, Christian Chapelle, Sandrine Parrot, Samy Cecioni, Jean-Pierre Praly, Kaïss Aouadi, Julie Guiard

Publikováno v: European Journal of Medicinal Chemistry. 98:237-249

Cycloaddition between (+) or (−)-menthone-derived nitrones and N-benzyl-3-pyrroline afforded enantiopure spiro-fused heterocycles. The reaction occurred enantio- and diastereo-selectively on the less hindered side of the nitrone, the 3-pyrroline N-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f17cdcc74dde51f4fb9e0db94bda33
https://doi.org/10.1016/j.ejmech.2015.05.017

NaBH3CN: A Janus Substitute for Tin-Free Radical-Based Reactions

Autor: Julie Guiard, Jean-Pierre Praly, Yaniss Rahali

Publikováno v: European Journal of Organic Chemistry. 2014:4461-4466

Beside showing that thermal radical reactions (reduction, Giese reaction) are efficient if bromo-/iodosugars are treated with NaBH3CN and 2,2″-azobisisobutyronitrile, we explored new initiation conditions on the basis of CuI salts (≤0.5 equiv.) s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d8cf128de0bae21bc0c75744c7f1948
https://doi.org/10.1002/ejoc.201402441

Crystal structure of human CD1e reveals a groove suited for lipid-exchange processes

Autor: Martine Gilleron, Gaëlle Giacometti, Gennaro De Libero, Lucia Mori, Daniel Hanau, Albert J. R. Heck, Cees Versluis, Diane de Paepe, Jacques Prandi, Julie Guiard, Germain Puzo, Laurent Maveyraud, Luis F. Garcia-Alles, Samuel Tranier, Lionel Mourey

Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences; Vol 108
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (32), pp.13230-13235. ⟨10.1073/pnas.1105627108⟩

International audience; CD1e is the only human CD1 protein existing in soluble form in the late endosomes of dendritic cells, where it facilitates the processing of glycolipid antigens that are ultimately recognized by CD1b-restricted T cells. The pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b60ea58639408c6e033c5aafbb7647e

Monoclonal Antibody-Defined Specific C Epitope of Brucella O-Polysaccharide Revisited

Autor: David R. Bundle, Julie Guiard, N. Vijaya Ganesh, Axel Cloeckaert, Michel S. Zygmunt

Publikováno v: Clinical and Vaccine Immunology
Clinical and Vaccine Immunology, American Society for Microbiology, 2015, 22 (8), pp.979-982. ⟨10.1128/CVI.00225-15⟩

The C epitope of Brucella O-polysaccharide (O-PS) has so far lacked definitive structural identity. Revised structures for this antigen revealed a unique capping perosamine tetrasaccharide consisting of a sequence of 1,2:1,3:1,2 interresidue linkages

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c4a07dfb740213a1ac8e9b57d34b47
https://hal.inrae.fr/hal-02630609

Structural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipids

Autor: Gennaro De Libero, Martine Gilleron, Anthony Collmann, Thérèse Brando, Albert J. R. Heck, Emilie Huc, Cees Versluis, Lionel Mourey, Luis F. Garcia-Alles, Steven A. Porcelli, Lucia Mori, Buko Lindner, Laurent Maveyraud, Julie Guiard, Germain Puzo, Sylviane Julien, Sebastiano Sansano, Jin S. Im, Jacques Prandi

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (43), pp.17755-17760. ⟨10.1073/pnas.1110118108⟩
Proceedings of the National Academy of Sciences; Vol 108
Proceedings of the National Academy of Sciences

International audience; The mechanisms permitting nonpolymorphic CD1 molecules to present lipid antigens that differ considerably in polar head and aliphatic tails remain elusive. It is also unclear why hydrophobic motifs in the aliphatic tails of so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cba2261face67ee3bc0c74043b6d06
https://pubmed.ncbi.nlm.nih.gov/22006319