Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease

Autor: Hans Jürgen Hoffmann, Natalia Pedersen, Morten Frydenberg, Sara Avlund, Marianne Thomsen, Stine Roug, Jacob Broder Brodersen, Jacob Sode, Ulla Vogel, Vibeke Østergaard Thomsen, Vibeke Andersen, Shaista Rashid, Johan Burisch, Bjørn A. Nexø, Thomas Bastholm Olesen, Stine Ydegaard Turino, Steffen Bank, Britt Kaiser Rasmussen, Julie Galsgaard, Paal Skytt Andersen

Publikováno v: Bank, S, Andersen, P S, Burisch, J, Pedersen, N, Roug, S, Galsgaard, J, Turino, S Y, Brodersen, J B, Rashid, S, Rasmussen, B K, Avlund, S, Olesen, T B, Hoffmann, H J, Thomsen, M K, Thomsen, V Ø, Frydenberg, M, Nexø, B A, Sode, J, Vogel, U & Andersen, V 2014, ' Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease ', Pharmacogenomics Journal, vol. 14, pp. 526–534 . https://doi.org/10.1038/tpj.2014.19
Bank, S, Andersen, P S, Burisch, J, Pedersen, N, Roug, S, Galsgaard, J, Turino, S Y, Brodersen, J B, Rashid, S, Rasmussen, B K, Avlund, S, Olesen, T B, Hoffmann, H J, Thomsen, M K, Thomsen, V Ø, Frydenberg, M, Nexø, B A, Sode, J, Vogel, U & Andersen, V 2014, ' Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease ', Pharmacogenomics Journal, pp. 526–534 . https://doi.org/10.1038/tpj.2014.19

Antitumor necrosis factor-α (TNF-α) is used for treatment of severe cases of inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). However, one-third of the patients do not respond to the treatment. Genetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f54e2cd193ed1906cc53092aa41ee0
https://doi.org/10.1038/tpj.2014.19

[Metformin and the obstetric patient]

Autor: Katrine Dahl, Pedersen, Nathalie Søderhamn, Bülow, Kasper, Aaboe, Julie, Galsgaard, Helle Sand, Odgaard, Elisabeth Reinhardt, Mathiesen, Jeannet, Lauenborg

Publikováno v: Ugeskrift for laeger. 177(50)

Polycystic ovary syndrome (PCOS) is associated with insulin resistance, infertility, obesity and gestational complications. Metformin is widely used in fertility treatment of women with PCOS, due to a suggested positive effect of continued metformin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::84e18fcb3e58d2e82c8422ef55c3c895
https://pubmed.ncbi.nlm.nih.gov/26651913

Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG are associated with susceptibility of inflammatory bowel disease in a Danish cohort

Autor: Shaista Rashid, Morten Frydenberg, Marianne Kragh Thomsen, Vibeke Østergaard Thomsen, Hans Jürgen Hoffmann, Natalia Pedersen, Jacob Sode, Britt Kaiser Rasmussen, Johan Burisch, Julie Galsgaard, Vibeke Andersen, Stine Ydegaard Turino, Paal Skytt Andersen, Steffen Bank, Ulla Vogel, Bjørn A. Nexø, Stine Roug, Thomas Bastholm Olesen, Sara Avlund, Jacob Broder Brodersen

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 6, p e98815 (2014)
Bank, S, Skytt Andersen, P, Burisch, J, Pedersen, N, Roug, S, Galsgaard, J, Ydegaard Turino, S, Broder Brodersen, J, Rashid, S, Kaiser Rasmussen, B, Avlund, S, Bastholm Olesen, T, Jürgen Hoffmann, H, Kragh Thomsen, M, Ostergaard Thomsen, V, Frydenberg, M, Andersen Nexø, B, Sode, J, Vogel, U & Andersen, V 2014, ' Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort ', PLOS ONE, vol. 9, no. 6, e98815 . https://doi.org/10.1371/journal.pone.0098815
Bank, S, Skytt Andersen, P, Burisch, J, Pedersen, N, Roug, S, Galsgaard, J, Ydegaard Turino, S, Broder Brodersen, J, Rashid, S, Kaiser Rasmussen, B, Avlund, S, Bastholm Olesen, T, Jürgen Hoffmann, H, Kragh Thomsen, M, Ostergaard Thomsen, V, Frydenberg, M, Andersen Nexø, B, Sode, J, Vogel, U & Andersen, V 2014, ' Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG are associated with susceptibility of inflammatory bowel disease in a Danish cohort ', PLOS ONE, vol. 9, no. 6, pp. e98815 . https://doi.org/10.1371/journal.pone.0098815

BACKGROUND: The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), result from the combined effects of susceptibility genes and environmental factors. Polymorphisms in genes regulating inflammation may explain part o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9ab4fd1eb100390de11d4cd699a188
https://pubmed.ncbi.nlm.nih.gov/24971461