Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Julie F, Falcone"'
Autor:
Robert F. Bruns, Qi Chen, Paloma Vidal, John Mehnert Schaus, Charles R. Yang, Stephen N. Mitchell, Steven Marc Massey, Nuria Diaz, Xushan Wang, David Andrew Coates, Rebecca A. Wright, Beverly A. Heinz, Kevin Matthew Gardinier, Greg Stephenson, James P. Beck, Rajni M. Bhardwaj, Julie F. Falcone, Bruce A. Dressman, Deanna L Maren, Anette M. Johansson, David Michael Remick, Jeff W. Cramer, Cohen Michael Philip, Brian Morgan Watson, Jeffery Richardson, Kjell Svensson, Xin Zhou, Erik James Hembre, Serge Louis Boulet, Reinhard Matthew Robert, Daniel S. Richards, Junliang Hao, David M. Bender, Guy Carter, Christopher David Beadle, Brian G. Getman, Wolfangel Craig Daniel, Diseroad Benjamin Alan, Jason K. Myers, Joseph H. Krushinski, David Edward Tupper
Publikováno v:
Journal of Medicinal Chemistry. 62:8711-8732
Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a353395d3c6f7ca6dfa78c95a347dd4
https://doi.org/10.1021/acs.jmedchem.9b01234
https://doi.org/10.1021/acs.jmedchem.9b01234
Autor:
Kjell A. Svensson, Julia K. Maxwell, Julie F. Falcone, Scott D. Gleason, Jeffrey M. Witkin, Olivia M. Balcer, Xia Li
Publikováno v:
Behavioural Brain Research. 359:467-473
5-HT7 receptors have been suggested to play a role in the regulation of psychiatric disorders. The experimental literature however is not fully consistent on this possibility. Two selective 5-HT7 receptor antagonists, DR-4004 and SB-269970, were eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e386aa16fb99357fc46ba42589abdbc6
https://doi.org/10.1016/j.bbr.2018.11.019
https://doi.org/10.1016/j.bbr.2018.11.019
Autor:
Junliang, Hao, James P, Beck, John M, Schaus, Joseph H, Krushinski, Qi, Chen, Christopher D, Beadle, Paloma, Vidal, Matthew R, Reinhard, Bruce A, Dressman, Steven M, Massey, Serge L, Boulet, Michael P, Cohen, Brian M, Watson, David, Tupper, Kevin M, Gardinier, Jason, Myers, Anette M, Johansson, Jeffery, Richardson, Daniel S, Richards, Erik J, Hembre, David M, Remick, David A, Coates, Rajni M, Bhardwaj, Benjamin A, Diseroad, David, Bender, Greg, Stephenson, Craig D, Wolfangel, Nuria, Diaz, Brian G, Getman, Xu-Shan, Wang, Beverly A, Heinz, Jeff W, Cramer, Xin, Zhou, Deanna L, Maren, Julie F, Falcone, Rebecca A, Wright, Stephen N, Mitchell, Guy, Carter, Charles R, Yang, Robert F, Bruns, Kjell A, Svensson
Publikováno v:
Journal of medicinal chemistry. 62(19)
Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38771cd6f379be26a1a0dc76826df19b
https://pubmed.ncbi.nlm.nih.gov/31532644
https://pubmed.ncbi.nlm.nih.gov/31532644
Autor:
Michelle M Menezes, Jeffrey M. Witkin, Kjell A. Svensson, Brian J. Eastwood, Eyassu Chernet, Michael J. O'Neill, Julie F. Falcone, Keith A. Wafford, Hong Wang, Linda K. Thompson, John W. Ryder, Stephen N. Mitchell, Junliang Hao, John Mehnert Schaus, Robert F. Bruns, Alex J. Harper, Meghane E. Masquelin, Deanna L Maren, Xia Li, Tracey K. Murray, Charles R. Yang, Elaine Shanks, Jason Katner, Linli Zhang, Guy Carter, James P. Beck, Patrick L. Love
Publikováno v:
Neuropharmacology. 128
DETQ, an allosteric potentiator of the dopamine D1 receptor, was tested in therapeutic models that were known to respond to D1 agonists. Because of a species difference in affinity for DETQ, all rodent experiments used transgenic mice expressing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4bdd0d92066c9741468043d0c8f34cb
https://pubmed.ncbi.nlm.nih.gov/29102759
https://pubmed.ncbi.nlm.nih.gov/29102759
Autor:
Mark J. Benvenga, Michael A. Statnick, Karen M. Knitowski, Julie Foss, Miguel A. Toledo, Alfonso Benito, Anke Post, Kirsti Lloyd, Michael Ansonoff, Alma Jiménez, Vanessa N. Barth, Maria Angeles Martinez-Grau, Janice W. Smith, Scott D. Gleason, Celia Lafuente, Linda M. Rorick-Kehn, John T. Catlow, Conception Pedregal, Nuria Diaz, Julie F. Falcone, Kjell A. Svensson, John E. Pintar, Steven Chaney, Xia Li, David L. McKinzie, Benjamin L. Adams, Jeffrey M. Witkin
Publikováno v:
Pharmacology Research & Perspectives
Nociceptin/Orphanin FQ (N/OFQ) is a 17 amino acid peptide whose receptor is designated ORL1 or nociceptin receptor (NOP). We utilized a potent, selective, and orally bioavailable antagonist with documented engagement with NOP receptors in vivo to ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cbf123c707e4aba252f069cf2e98ce
http://europepmc.org/articles/PMC5226289
http://europepmc.org/articles/PMC5226289
Autor:
Junliang Hao, Wesley H. Anderson, Cohen Michael Philip, Kjell A. Svensson, Michael A. Statnick, Donald R. Gehlert, Joseph H. Krushinski, Hellman Sarah Lynne, Michelle M Menezes, Jeffrey W Cramer, Julie F. Falcone, Xushan Wang, Rebecca A. Wright, John Mehnert Schaus, Neil W. DeLapp, Reinhard Matthew Robert, S Michelle Morin, Charles R. Yang, Todd R. Wiernicki, Ilya Okun, Renee Emkey, Benjamin L. Adams, Beverly A. Heinz, Brian G. Getman, James P. Beck, Robert F. Bruns, Virginia L. Lucaites, Todd M. Suter, Deanna L Maren, David L. Nelson, Kelly L. Knopp, Borys V. Rogovoy
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
Allosteric potentiators amplify the sensitivity of physiologic control circuits, a mode of action that could provide therapeutic advantages. This hypothesis was tested with the dopamine D1 receptor potentiator DETQ [2-(2,6-dichlorophenyl)-1-((1S,3R)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407266480ca7b482e7f8dd098b6484ac
https://pubmed.ncbi.nlm.nih.gov/27811173
https://pubmed.ncbi.nlm.nih.gov/27811173
Autor:
Kjell Svensson, David L. McKinzie, Kenneth W. Perry, David Lee Nelson, Julie F. Falcone, Penny G. Threlkeld, Karen S. Rash, Matthew J. Fell, Gerard J. Marek, Virginia L. Lucaites, Vanessa N. Barth, James A. Monn, Bryan G. Johnson
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 331:1126-1136
Some recently published in vitro studies with two metabotropic glutamate 2/3 receptor (mGluR(2/3)) agonists [(-)-2-oxa-4-aminobicyclo[3.1.0] hexane-4,6-dicarboxylic acid (LY379268) and 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-bicaroxylate monohydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4f19e0255ffb5e89d3e1bc3f05ba37c
https://doi.org/10.1124/jpet.109.160598
https://doi.org/10.1124/jpet.109.160598
Autor:
Kimberly D. Gordon, Julie F. Falcone, Teresa Man, Harlan E. Shannon, Hong Yu, Kjell A. Svensson, Kalpana M. Merchant, Magnus Wilhelm Walter, Lijuan Yang, Beth J. Hoffmann, Carrie K. Jones, Kirk W. Johnson, Lee A. Phebus, Matthew J. Fell, Annick J. Cauvin, Mark R. Wade, George E. Sandusky, John W. Ryder, Kenneth W. Perry, Patrick L. Love, Warren J. Porter, Jason Katner, George G. Nomikos
Publikováno v:
Neuropharmacology. 55:743-754
Selective inhibitors of the glycine transporter 1 (GlyT1) have been implicated in central nervous system disorders related to hypoglutamatergic function such as schizophrenia. The selective GlyT1 inhibitors ALX5407 (NFPS) and LY2365109 {[2-(4-benzo[1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6386d461057f4b5a894ada397d3c99
https://doi.org/10.1016/j.neuropharm.2008.06.016
https://doi.org/10.1016/j.neuropharm.2008.06.016
Autor:
Delbert Bauzon, Neil W. DeLapp, Frank P. Bymaster, Julie F. Falcone, Marlene L. Cohen, Kathryn W. Schenck, John S. Kennedy
Publikováno v:
European Journal of Pharmacology. 430:341-349
The interaction of the psychotropic agent olanzapine with serotonin 5-HT(3) and 5-HT(6) receptors was investigated. Olanzapine did not contract the isolated guinea pig ileum, but blocked contractions induced by the 5-HT(3) receptor agonist 2-methyl s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb489fd07cde7a3211585669ab5872f0
https://doi.org/10.1016/s0014-2999(01)01399-1
https://doi.org/10.1016/s0014-2999(01)01399-1
Autor:
Petra A. Carter, Marlene L. Cohen, Frank P. Bymaster, Jürgen Wess, Lu Zhang, Julie F. Falcone, Harlan E. Shannon, Jesus Gomeza, Christian C. Felder, Peter W. Stengel
Publikováno v:
Life Sciences. 68:2473-2479
Determination of muscarinic agonist-induced parasympathomimetic effects in wild type and M2 and M4 muscarinic receptor knockout mice revealed that M2 receptors mediated tremor and hypothermia, but not salivation. The M4 receptors seem to play a modes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28e4d5271f408216f1c0c955da7d4c2
https://doi.org/10.1016/s0024-3205(01)01041-4
https://doi.org/10.1016/s0024-3205(01)01041-4