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pro vyhledávání: '"Julie Elizabeth Brumwell"'
Autor:
Lal Chima, Pretswell Ian Andrew, Michael Bryan Roe, Wendy Dangerfield, Adrian Folkes, Ashworth Philip Anthony, Julie Elizabeth Brumwell, Hamish Ryder, Peter Charlton, Sukhjit Hunjan
Publikováno v:
ChemInform. 30
We have synthesised and evaluated a series of anthranilamide based modulators of P-glycoprotein. These studies have identified XR9576(2), a potent inhibitor of P-glycoprotein in vitro and in vivo. The general synthesis and the SAR of these compounds
Autor:
Julie Elizabeth Brumwell, Lal Chima, Wendy Dangerfield, Adrian Folkes, Pretswell Ian Andrew, Sukhjit Hunjan, Hamish Ryder, Michael Bryan Roe, Ashworth Philip Anthony, Peter Charlton
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(4)
We have synthesised and evaluated a series of anthranilamide based modulators of P-glycoprotein. These studies have identified XR9576(2), a potent inhibitor of P-glycoprotein in vitro and in vivo. The general synthesis and the SAR of these compounds