Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Julie Elisabeth Heggelund"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Transglutaminase 3 (TG3), the autoantigen of dermatitis herpetiformis (DH), is a calcium dependent enzyme that targets glutamine residues in polypeptides for either transamidation or deamidation modifications. To become catalytically active
Externí odkaz:
https://doaj.org/article/7086bf68c62a49909723f5d535c05f49
Autor:
Julie Elisabeth Heggelund, Alasdair Mackenzie, Tobias Martinsen, Joel Benjamin Heim, Pavel Cheshev, Anna Bernardi, Ute Krengel
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Cholera is a life-threatening disease in many countries, and new drugs are clearly needed. C-glycosidic antagonists may serve such a purpose. Here we report atomic-resolution crystal structures of three such compounds in complexes with the c
Externí odkaz:
https://doaj.org/article/d8b34731a07e4f5099ce552d4d1ee6e9
Autor:
Julie Elisabeth Heggelund, Joel Benjamin Heim, Gregor Bajc, Vesna Hodnik, Gregor Anderluh, Ute Krengel
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 3, p 703 (2019)
Diarrhea caused by enterotoxigenic Escherichia coli (ETEC) is one of the leading causes of mortality in children under five years of age and is a great burden on developing countries. The major virulence factor of the bacterium is the heat-labile ent
Externí odkaz:
https://doaj.org/article/82b578eca9d248a6985ace1f241a78d4
Autor:
Julie Elisabeth Heggelund, Daniel Burschowsky, Victoria Ariel Bjørnestad, Vesna Hodnik, Gregor Anderluh, Ute Krengel
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005567 (2016)
Cholera is the prime example of blood-group-dependent diseases, with individuals of blood group O experiencing the most severe symptoms. The cholera toxin is the main suspect to cause this relationship. We report the high-resolution crystal structure
Externí odkaz:
https://doaj.org/article/680edf2eb5334937ac94a1d2c13eb603
Autor:
Ute Krengel, Helene Mykland Hoås, Gertrudis Rojas, Lene Støkken Høydahl, Daniel Burschowsky, Fana Abraha, Julie Elisabeth Heggelund, Paula A. Bousquet, Hedda Johannesen, Noha Abdel-Rahman, Geir Åge Løset, Kaare Bjerregaard-Andersen, Stefan Oscarson
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
'Scientific Reports ', vol: 8, pages: 10836-1-10836-11 (2018)
Scientific Reports
'Scientific Reports ', vol: 8, pages: 10836-1-10836-11 (2018)
Scientific Reports
Targeted cancer immunotherapy offers increased efficacy concomitantly with reduced side effects. One antibody with promising clinical potential is 14F7, which specifically recognises the NeuGc GM3 ganglioside. This antigen is found in the plasma memb
Autor:
Gregor Anderluh, Gregor Bajc, Julie Elisabeth Heggelund, Vesna Hodnik, Ute Krengel, Joel B. Heim
Diarrhoea caused by enterotoxigenic Escherichia coli is one of the leading causes of mortality in children under five years of age and is a great burden on developing countries. The major virulence factor of the bacterium is the heat-labile enterotox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd8cff8176a4787c7d0a4887e4e6c687
https://doi.org/10.20944/preprints201812.0236.v2
https://doi.org/10.20944/preprints201812.0236.v2
Autor:
Julie Elisabeth, Heggelund, Joel Benjamin, Heim, Gregor, Bajc, Vesna, Hodnik, Gregor, Anderluh, Ute, Krengel
Publikováno v:
International Journal of Molecular Sciences
Diarrhea caused by enterotoxigenic Escherichia coli (ETEC) is one of the leading causes of mortality in children under five years of age and is a great burden on developing countries. The major virulence factor of the bacterium is the heat-labile ent
Autor:
Gregor Bajc, Ute Krengel, Joel B. Heim, Julie Elisabeth Heggelund, Gregor Anderluh, Vesna Hodnik
Diarrhoea caused by enterotoxigenic Escherichia coli is one of the leading causes of mortality in children under five years of age and is a great burden on developing countries. The major virulence factor of the bacterium is the heat-labile enterotox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32c4a01b1671051f4ddfb1eaff6a4b3b
https://doi.org/10.20944/preprints201812.0236.v1
https://doi.org/10.20944/preprints201812.0236.v1
Cholera is a life-threatening diarrhoeal disease caused by the human pathogenVibrio cholerae. Infection occurs after ingestion of the bacteria, which colonize the human small intestine and secrete their major virulence factor - the cholera toxin (CT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5e97402ee81bd2e0b505071bc7154a
Publikováno v:
Current Opinion in Structural Biology
Current Opinion in Structural Biology, Elsevier, 2017, 44, pp.190-200. ⟨10.1016/j.sbi.2017.04.001⟩
Current Opinion in Structural Biology, Elsevier, 2017, 44, pp.190-200. ⟨10.1016/j.sbi.2017.04.001⟩
The critical first step of a microbial infection is usually the attachment of pathogens to host cell glycans. Targets on host tissues are in particular the histo-blood group antigens (HBGAs), which are present in rich diversity in the mucus layer and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ddfa8a5cacfd62714289f273d4817d
https://hal.archives-ouvertes.fr/hal-02377944/document
https://hal.archives-ouvertes.fr/hal-02377944/document