Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Julie E. Zeskind"'
Publikováno v:
Proceedings of the American Thoracic Society. 5:834-841
While the role cigarette smoke plays in chronic obstructive pulmonary disease (COPD) is undisputed, the molecular mechanisms by which inhaled smoke contributes to disease pathogenesis remains unclear. One of the major barriers to effective approaches
Autor:
Melissa D. Krebs, Maria E. Holmboe, Robert D. Tingley, Joung Mo Kang, Julie E. Zeskind, Cristina E. Davis
Publikováno v:
Chemometrics and Intelligent Laboratory Systems. 81:74-81
Analyzing the response of analytical sensors to complex chemical mixtures is difficult, as signals may overlap and may vary between experiments. The analysis and comparison of data files depends on their repeatability, and misaligned signals will not
Autor:
Julie E. Zeskind, Cristina E. Davis, Melissa D. Krebs, Maria E. Holmboe, Joung-Mo Kang, Robert D. Tingley
Publikováno v:
Bioinformatics. 21:1325-1331
Summary: The analysis of chromatographic data resulting from complex chemical mixtures is challenging. Components may co-elute, causing their signals to overlap. An algorithm that will increase the signal-to-noise ratio so compounds present in low ab
Autor:
Masaru Suzuki, James C. Hogg, Marc E. Lenburg, Shizu Hayashi, Corry-Anke Brandsma, Ji Xiao, Dmitri V. Pechkovsky, Xiaohui Zhang, Joel D. Cooper, Yuriy O. Alekseyev, Darryl A. Knight, Tillie L. Hackett, Gang Liu, Joshua D. Campbell, Dirkje S. Postma, Wim Timens, Avrum Spira, John E. McDonough, Julie E. Zeskind, John V. Gosselink
Publikováno v:
Genome medicine, 4:67. BMC
Genome Medicine
Genome Medicine
Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease consisting of emphysema, small airway obstruction, and/or chronic bronchitis that results in significant loss of lung function over time.Methods: In order to gain ins
Autor:
Joel D. Cooper, Masaru Suzuki, James C. Hogg, John V. Gosselink, John E. McDonough, Julie E. Zeskind, Marc E. Lenburg, Avrum Spira, Shizu Hayashi, W M. Elliott
Publikováno v:
B42. COPD PATHOGENESIS: CELLULAR EXPRESSION AND PROTEIN RESPONSES.
Autor:
Masaru Suzuki, James C. Hogg, Julie E. Zeskind, Avrum Spira, Marc E. Lenburg, Alexander C. Wright, Shizu Hayashi, John E. McDonough, Xiaohui Zhang, Joel D. Cooper, Debra E. Horng, Pablo G. Sanchez, Gang Liu
Publikováno v:
C22. PATHOBIOLOGY OF COPD: LESSONS FROM INFLAMMATORY MECHANISMS AND GENOMIC STUDIES.
Rationale: To gain insights into molecular processes that contribute to airway-wall thickening and alveolar destruction in COPD, and the relationship between these two processes, we microdissected airway and parenchyma from resected lungs obtained fr
Autor:
Marc E. Lenburg, Joshua D. Campbell, Alexander C. Wright, Gang Liu, James C. Hogg, Joel D. Cooper, Pablo G. Sanchez, Avrum Spira, Debra E. Horng, Shizu Hayashi, Julie E. Zeskind, John E. McDonough
Publikováno v:
B105. CHRONIC OBSTRUCTIVE PULMONARY DISEASE: PATHOGENESIS AND MECHANISMS OF DISEASE.
To gain insights into the pathogenesis of chronic obstructive pulmonary disease (COPD), we profiled gene expression in Introduction: regions with differing emphysema severity from six lungs with COPD and two donor lungs. Regional emphysema severity w
Autor:
Randall R. Reed, Maria E. Holmboe, Nina Heinrich, Kanet Wongravee, Michele L. Schaefer, Julie E. Zeskind, Heather Kulaga, Richard G. Brereton, Jose M. Trevejo, Sarah J. Dixon
Publikováno v:
Chemical senses. 35(6)
Body fluids such as urine potentially contain a wealth of information pertaining to age, sex, social and reproductive status, physiologic state, and genotype of the donor. To explore whether urine could encode information regarding environment, physi
Autor:
Avrum Spira, James C. Hogg, Marc E. Lenburg, Julie E. Zeskind, Joel D. Cooper, Debra E. Horng, Sherry Zhang, John E. McDonough, Alexander C. Wright, Gang Liu, Pablo G. Sanchez, Shizu Hayashi
Publikováno v:
B39. COPD: GENETICS.
Rationale: To gain insights into the molecular processes that contribute to the progression of COPD, we used resected whole lungs from individuals undergoing lung transplantation for severe COPD to identify gene and microRNA expression between region
Autor:
Jerome S. Brody, Yves-Martine Dumas, Marc E. Lenburg, Adam M. Gustafson, Julie E. Zeskind, Katrina Steiling, Vishal Shah, Frank Schembri, Avrum Spira, Gang Liu, Xiaohui Zhang, Sriram Sridhar
Publikováno v:
BMC Genomics, Vol 9, Iss 1, p 259 (2008)
BMC Genomics
BMC Genomics
Background Cigarette smoking is a leading cause of preventable death and a significant cause of lung cancer and chronic obstructive pulmonary disease. Prior studies have demonstrated that smoking creates a field of molecular injury throughout the air