Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Julie E. White"'
Autor:
Min-Fu Tsan, Julie E. White
Publikováno v:
Journal of Endotoxin Research. 6:329-335
E5531, a synthetic lipid A analog, has been shown to inhibit endotoxin (lipopolysaccharide, LPS)-induced tumor necrosis factor-alpha (TNF-alpha) production by human monocytes and murine macrophages. Whether it also inhibits LPS induction of manganese
Publikováno v:
British Journal of Haematology. 109:405-412
Resveratrol, a natural product present in wine, has recently been shown to inhibit the growth of a number of cancer cell lines in vitro. In the current study, we have demonstrated that resveratrol inhibits the growth of THP-1 human monocytic leukaemi
Publikováno v:
Journal of Cellular Physiology. 182:381-389
A mutant Escherichia coli lipopolysaccharide (LPS) lacking myristoyl fatty acid markedly stimulates the activity of manganese superoxide dismutase (MnSOD) without inducing tumor necrosis factor alpha (TNFalpha) production by human monocytes (Tian et
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 20:465-473
The mechanism by which pertussis toxin (Ptx) causes lung edema is not clear. We investigated the role of pulmonary manganese superoxide dismutase (MnSOD) and protein kinase C (PKC) in Ptx-induced lung edema. We demonstrated that intraperitoneal injec
Publikováno v:
Experimental Lung Research. 22:651-666
Tracheal insufflation of chloramphenicol acetyltransferase (CAT) expression plasmid (pBL-CAT) DNA without any gene delivery system results in transfection of rat lungs (Am J Physiol. 1995;268:L1052-L1056). This study investigated the pulmonary respon
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 268:L1052-L1056
A number of gene delivery methods have been developed to facilitate gene transfer into mammalian somatic cells in vivo. In this study, we demonstrated that tracheal insufflation of two recombinant plasmids containing a bacterial gene, chloramphenicol
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 12:339-344
Endotoxin lipopolysaccharide and the cytokines, tumor necrosis factor (TNF) and interleukin-1 (IL-1), are known to protect adult rats against O2 toxicity. However, whether the effect of endotoxin is mediated by these cytokines is not clear. We have p
Autor:
Julie E. White, Min-Fu Tsan
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 266:L664-L671
We have previously demonstrated that intratracheal (IT) but not intraperitoneal (IP) administration of 5 micrograms tumor necrosis factor (TNF) or interleukin-1 (IL-1) selectively enhances pulmonary Mn superoxide dismutase (Mn SOD) mRNA, leading to i
Hyperoxic stress elevates p52(PAI-1) mRNA abundance in cultured cells and adult rat pulmonary tissue
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 265:L121-L126
Hyperoxic stress alters expression of genes involved in extracellular matrix (ECM) remodeling. To identify novel ECM-associated gene products positively regulated by hyperoxia, rat kidney cells were exposed to 95% O2, and the complement of [35S]methi
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 5:556-562
The effect of tumor necrosis factor-alpha (TNF) on hyperoxia-induced endothelial injury in vitro was investigated. TNF caused a time- and dose-dependent reduction in the number of viable pulmonary artery endothelial cells. The TNF-mediated endothelia