Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Julie E. Trim"'
Autor:
Steven Tucker, Tanya Monaghan, Julie E. Trim, Carylyn J. Marek, Matthew Koruth, Derek A. Mann, Matthew C. Wright, Valerie Hilda Marie Duncan Leel, Emma Louise Haughton, Elaina Susan Renata Collie-Duguid, Elaine Durward, Z. Bascal
Publikováno v:
Gastroenterology. 131:194-209
Background & Aims: The activated pregnane X receptor is antifibrogenic in rodent chronic liver injury in vivo models. The aim of this study was to determine the effects of human pregnane X receptor activators on human hepatic stellate cell transdiffe
Autor:
Pitt Gary Robert William, Rooker David Philip, Robert Haigh, Andrew M. Penson, Andrzej Roman Batt, André Tartar, Peter A. Robson, Julie E. Trim, Michael Bryan Roe, Yea Christopher Martyn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4585-4589
A library of compounds targeted to the vasopressin/oxytocin family of receptors was screened for activity at a cloned human oxytocin receptor using a reporter gene assay. Potency and selectivity were optimised to afford compound 39, EC50 = 33 nM. Thi
Autor:
Julie E. Trim, David E. Smart, Karen J. Vincent, Michael J. P. Arthur, Erick C. Jones, Matthew C. Wright, Derek A. Mann
Publikováno v:
Gut. 49:713-719
BACKGROUND—Activation of hepatic stellate cells (HSCs) to a myofibroblastic phenotype is a key event in liver fibrosis. Identification of transcription factors with activities that are modulated during HSC activation will improve our understanding
Publikováno v:
Molecular and cellular endocrinology. 333(1)
Defining key differences between agonist and antagonist binding to hormone receptors is important and will aid rational drug design. Glu(1.35) in transmembrane helix 1 (TM1) of the human oxytocin receptor (OTR) is absolutely conserved in all OTRs clo
Autor:
Maria A. Juliano, Sachiko I. Blaber, Hyesook Yoon, D. Michael Evans, Julie E. Trim, Michael Blaber, Isobel A. Scarisbrick
The human kallikrein-related peptidases (KLKs) comprise 15 members (KLK1–15) and are the single largest family of serine proteases. The KLKs are utilized, or proposed, as clinically important biomarkers and therapeutic targets of interest in cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bbefac7520eda1aaa1b7cd85d6cc946
https://europepmc.org/articles/PMC2578812/
https://europepmc.org/articles/PMC2578812/
Autor:
Zoe Lawson, Julie E. Trim, Matthew T. Conner, Stuart R. Hawtin, John Simms, Rosemary A. Parslow, Mark Wheatley, Andrew Sheppard
Publikováno v:
The Journal of biological chemistry. 281(50)
For G-protein-coupled receptors (GPCRs) in general, the roles of extracellular residues are not well defined compared with residues in transmembrane helices (TMs). Nevertheless, extracellular residues are important for various functions in both pepti
Autor:
Val Leel, Matthew C. Wright, Carylyn J. Marek, Lucy J. Elrick, James G. Orr, Julie E. Trim, Emma Louise Haughton, Gary A. Cameron, Gabrielle M. Hawksworth, Andrew P. Halestrap
Publikováno v:
Hepatology (Baltimore, Md.). 40(1)
Gliotoxin has been shown to promote a reversal of liver fibrosis in an animal model of the disease although its mechanism of action in the liver is poorly defined. The effects of gliotoxin on activated hepatic stellate cells (HSCs) and hepatocytes ha
Autor:
Satinder K. Samra, Michael J. P. Arthur, Matthew C. Wright, Raj Beri, Martin McAulay, Julie E. Trim, Derek A. Mann
Publikováno v:
The Journal of biological chemistry. 275(9)
Elevated expression of the tissue inhibitor of metalloproteinases-1 (TIMP-1) protein and mRNA has been reported in human diseases including cancers and tissue fibrosis. Regulation of TIMP-1 gene expression is mainly mediated at the level of gene tran