Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Julie E. McMinn"'
Publikováno v:
International Journal of Obesity. 31:395-402
Obesity is strongly associated with female infertility, but the mechanisms underlying this relationship are largely unknown.We investigated the effect of increasing dietary fat percentage upon body mass, hypothalamic neuropeptide gene expression, adi
Autor:
Streamson C. Chua, Paula Dietrich, Shun Mei Liu, Hong Liu, Carol N. Boozer, Thomas Ludwig, Julie E. McMinn, Ioannis Dragatsis
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 289:E403-E411
Leptin signaling in the brain regulates energy intake and expenditure. To test the degree of functional neuronal leptin signaling required for the maintenance of body composition, fertility, and cold tolerance, transgenic mice expressing Cre in neuro
Autor:
Nina Balthasar, Bradford B. Lowell, Christopher D. Kenny, Charlotte E. Lee, Roberto Coppari, Robert A. McGovern, Joel K. Elmquist, Streamson C. Chua, Julie E. McMinn, Shun M. Liu, Vinsee Tang
Publikováno v:
Neuron. 42:983-991
Neuroanatomical and electrophysiological studies have shown that hypothalamic POMC neurons are targets of the adipostatic hormone leptin. However, the physiological relevance of leptin signaling in these neurons has not yet been directly tested. Here
Publikováno v:
Endocrinology. 145:1238-1247
The effects of diet and adiposity have been implicated in disturbances of female reproductive function. In an effort to better elucidate the relationship between obesity and female fertility, we analyzed the effect of increasing dietary fat content o
Autor:
Ambrose A. Dunn-Meynell, Julie E. McMinn, Amy Cunningham-Bussel, Barry E. Levin, Michael Alperovich, Streamson C. Chua
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 285:R1184-R1191
Previous breeding for the diet-induced obese (DIO) trait from outbred Sprague-Dawley rats produced a substrain with selection characteristics suggesting a polygenic mode of inheritance. To assess this issue further, selectively bred DIO male rats wer
Publikováno v:
Endocrinology. 141:4442-4448
Leptin administration potentiates the satiety response to signals such as cholecystokinin (CCK), that are released from the gut during a meal. To investigate the physiological relevance of this observation, we hypothesized that leptin deficiency, ind
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 279:R695-R703
α-Melanocyte-stimulating hormone (α-MSH) is a hypothalamic neuropeptide proposed to play a key role in energy homeostasis. To investigate the behavioral, metabolic, and hypothalamic responses to chronic central α-MSH administration, α-MSH was inf
Autor:
Randy J. Seeley, Michael W. Schwartz, Julie E. McMinn, Charles W. Wilkinson, Stephen C. Woods, Peter J. Havel
Publikováno v:
Regulatory Peptides. :425-431
To test the hypothesis that NPY-induced overfeeding activates compensatory responses that inhibit hypothalamic NPY gene expression, we investigated the effect of chronically administered neuropeptide Y (NPY) on plasma hormones involved in energy bala
Autor:
Daniella Loh, Yiying Zhang, Kaiying Guo, Streamson C. Chua, Julie E. McMinn, Lulu Chen, Guoqing Yang, Yi-Hao Yu, Thomas Ludwig, Cai Li
Publikováno v:
Endocrinology. 148(8)
Although central leptin signaling appears to play a major role in the regulation of food intake and energy metabolism, the physiological role of peripheral leptin signaling and its relative contribution to whole-body energy metabolism remain unclear.
Autor:
Gregory J. Morton, Linda Ste. Marie, Julie E. McMinn, Grant I. Miura, Richard D. Palmiter, Dana K. Sindelar, Michael W. Schwartz
Publikováno v:
Endocrinology. 145(7)
To investigate the role played by the orexigenic peptide, neuropeptide Y (NPY), in adaptive responses to insulin-induced hypoglycemia, we measured hypothalamic, feeding, and hormonal responses to this stimulus in both wild-type (Npy+/+) and NPY-defic