Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Julie E. Hines"'
Publikováno v:
The Journal of Pathology. 185:298-302
In vitro studies have shown hepatocyte growth factor (HGF) to be a potent mitogen for hepatocytes. Direct evidence of a mitogenic role in vivo was sought by inhibiting HGF activity, using continuous administration of neutralizing antibody to rats whi
Autor:
Julie E. Hines, Alastair D. Burt, Kieran Toole, Claire Chapman, Joseph P. Mathew, Andrew W. Burr
Publikováno v:
The Journal of Pathology. 179:276-282
In order to characterize the role of transforming growth factor-alpha (TGF alpha) during hepatocarcinogenesis, liver tissue was examined at 10, 16, and 19 weeks following initial 10-week diethylnitrosamine (50 mg l-1 drinking water) exposure in femal
Publikováno v:
The Journal of Pathology. 179:74-79
CD44 and its variant isoforms are a group of transmembrane glycoproteins which play important roles in immune recognition, in lymphocyte trafficking, and in cell-cell and cell-matrix interactions. Although CD44 is expressed by some normal human epith
Autor:
Andrew F. Walls, Alastair D. Burt, Julie E. Hines, Peter J. Kelly, Mark K. Bennett, Desmond J. Farrell
Publikováno v:
Hepatology. 22:1175-1181
Mast cells are known to be present in human liver but their distribution and density in normal livers and in chronic liver diseases have not previously been examined. In this study, we quantified mast cell numbers and examined their distribution in p
Autor:
Desmond J. Farrell, Julie E. Hines, Andrew F. Walls, Peter J. Kelly, Mark K. Bennett, Alastair D. Burt
Publikováno v:
Hepatology. 22:1175-1181
Autor:
Julie E. Hines, Oliver F. W. James, Alastair D. Burt, Kieran Toole, Sarah J. Johnson, Joseph P. Mathew
Publikováno v:
Histopathology. 25:65-70
Immunohistochemistry and image analysis were used to quantify alterations in the Kupffer cell and 'activated' perisinusoidal cell populations in the different stages of primary biliary cirrhosis. Anti-CD68 macrophage antibodies were used to detect Ku
Publikováno v:
Journal of Hepatology. 20:537-541
We have analysed Kupffer cell and 'activated' perisinusoidal cell populations in liver biopsies from patients with paracetamol (acetaminophen)-induced hepatic necrosis of varying degrees of severity. Kupffer cells were identified immunohistochemicall
Publikováno v:
The Journal of Pathology. 170:95-100
The distribution of transforming growth factor-alpha (TGF alpha) in rat liver during regeneration was studied immunohistochemically using two antibodies, one a polyclonal (26T) raised against a synthetic peptide corresponding to the 17 C-terminal ami
Autor:
A G Hall, Joseph P. Mathew, Alastair D. Burt, Julie E. Hines, A R Cattan, R Nelson, E. J. Eastham
Publikováno v:
Journal of Clinical Pathology. 45:679-683
AIMS: To investigate the distribution of alpha and pi class glutathione S-transferases (GST) in normal fetal, neonatal, and adult liver; and to examine changes in GST expression in neonatal liver disease. METHODS: alpha and pi class GST were immunolo
Publikováno v:
The Histochemical Journal. 24:67-72
There is now substantial evidence that perisinusoidal (Ito or fat-storing) cells are the principal source of extracellular matrix proteins during hepatic fibrogenesis. In rat liver these cells express the intermediate filament protein desmin; this is