Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Julie E, Cansfield"'
Autor:
Stacey M. Southall, Joydeep Banerjee, Jason Brown, Kristina Butkovic, Andrew D. Cansfield, Julie E. Cansfield, Miles S. Congreve, Gabriella Cseke, Francesca Deflorian, Martina Petrovic Hunjadi, Antun Hutinec, Trinadh Kumar Inturi, Renata Rupcic, Gordon Saxty, Stephen P. Watson
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1776-1782
The diastereomeric macrocyclic calcitonin generelated peptide (CGRP) antagonists HTL0029881 (3) and HTL0029882 (4), in which the stereochemistry of a spiro center is reversed, surprisingly demonstrate comparable potency. X-ray crystallographic charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6056f84865bf327ec61e26bf41ed7b3
https://doi.org/10.1021/acsmedchemlett.2c00400
https://doi.org/10.1021/acsmedchemlett.2c00400
Autor:
Paul Workman, Martin Drysdale, Sue Eccles, Florence Raynaud, Edward McDonald, Keith Jones, Laurence Pearl, Wynne Aherne, Roderick E. Hubbard, Nicolas Foloppe, Allan Surgenor, Lisa Wright, Julie E. Cansfield, Xavier Barril, Paul A. Brough, Brian Dymock, Anthea Hardcastle, Angela Hayes, Karen James, Andrew Kalusa, Kwai-Ming J. Cheung, Thomas P. Matthews, Gary Box, Joanna L. Holmes, Marissa V. Powers, Kathy Boxall, Chrisostomos Prodromou, Swee Y. Sharp
Adobe PDF - MCT-07-0149--Suppl_Data.pdf from Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4d7fb2338ed0110488ee5feca6169d
https://doi.org/10.1158/1535-7163.22485900
https://doi.org/10.1158/1535-7163.22485900
Autor:
Paul Workman, Martin Drysdale, Sue Eccles, Florence Raynaud, Edward McDonald, Keith Jones, Laurence Pearl, Wynne Aherne, Roderick E. Hubbard, Nicolas Foloppe, Allan Surgenor, Lisa Wright, Julie E. Cansfield, Xavier Barril, Paul A. Brough, Brian Dymock, Anthea Hardcastle, Angela Hayes, Karen James, Andrew Kalusa, Kwai-Ming J. Cheung, Thomas P. Matthews, Gary Box, Joanna L. Holmes, Marissa V. Powers, Kathy Boxall, Chrisostomos Prodromou, Swee Y. Sharp
Although the heat shock protein 90 (HSP90) inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) shows clinical promise, potential limitations encourage development of alternative chemotypes. We discovered the 3,4-diarylpyrazole resorcinol CCT018
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073e5066d6b9dde949d7a67d06d663c3
https://doi.org/10.1158/1535-7163.c.6532131
https://doi.org/10.1158/1535-7163.c.6532131
Autor:
Paul Workman, Lisa Wright, Mike Wood, Paul Webb, Alan Surgenor, Roderick E. Hubbard, Rob Howes, Harry Finch, Martin J. Drysdale, Brian Dymock, Julie E. Cansfield, Paul A. Brough, Xavier Barril, Edward McDonald, Keith Jones, Andrew Kalusa, Kwai-Ming Cheung, Thomas P. Matthews, Karen James, Laurence Pearl, Chrisostomos Prodromou, Kathy Boxall, Frederique Urban, Vanessa Martins, Angela Hayes, Martin Rowlands, Wynne Aherne, Frances Boxall, Sharon Gowan, Alexis de Haven Brandon, Lisa Patterson, Melanie Valenti, Gary Box, Swee Y. Sharp, Florence I. Raynaud, Andy Massey, Suzanne A. Eccles
We describe the biological properties of NVP-AUY922, a novel resorcinylic isoxazole amide heat shock protein 90 (HSP90) inhibitor. NVP-AUY922 potently inhibits HSP90 (Kd = 1.7 nmol/L) and proliferation of human tumor cells with GI50 values of approxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78b088007e80570e9e0ca4c1e859a063
https://doi.org/10.1158/0008-5472.c.6497295
https://doi.org/10.1158/0008-5472.c.6497295
Autor:
Paul Workman, Lisa Wright, Mike Wood, Paul Webb, Alan Surgenor, Roderick E. Hubbard, Rob Howes, Harry Finch, Martin J. Drysdale, Brian Dymock, Julie E. Cansfield, Paul A. Brough, Xavier Barril, Edward McDonald, Keith Jones, Andrew Kalusa, Kwai-Ming Cheung, Thomas P. Matthews, Karen James, Laurence Pearl, Chrisostomos Prodromou, Kathy Boxall, Frederique Urban, Vanessa Martins, Angela Hayes, Martin Rowlands, Wynne Aherne, Frances Boxall, Sharon Gowan, Alexis de Haven Brandon, Lisa Patterson, Melanie Valenti, Gary Box, Swee Y. Sharp, Florence I. Raynaud, Andy Massey, Suzanne A. Eccles
Supplementary Figure 6 from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14fdf2f6b82f94d767294c9c5de8c3e9
https://doi.org/10.1158/0008-5472.22374012
https://doi.org/10.1158/0008-5472.22374012
Autor:
Paul Workman, Lisa Wright, Mike Wood, Paul Webb, Alan Surgenor, Roderick E. Hubbard, Rob Howes, Harry Finch, Martin J. Drysdale, Brian Dymock, Julie E. Cansfield, Paul A. Brough, Xavier Barril, Edward McDonald, Keith Jones, Andrew Kalusa, Kwai-Ming Cheung, Thomas P. Matthews, Karen James, Laurence Pearl, Chrisostomos Prodromou, Kathy Boxall, Frederique Urban, Vanessa Martins, Angela Hayes, Martin Rowlands, Wynne Aherne, Frances Boxall, Sharon Gowan, Alexis de Haven Brandon, Lisa Patterson, Melanie Valenti, Gary Box, Swee Y. Sharp, Florence I. Raynaud, Andy Massey, Suzanne A. Eccles
Supplementary Figure 3A-B from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6732ffbc7fb41b816f3957077315e5
https://doi.org/10.1158/0008-5472.22374030
https://doi.org/10.1158/0008-5472.22374030
Autor:
Paul Workman, Lisa Wright, Mike Wood, Paul Webb, Alan Surgenor, Roderick E. Hubbard, Rob Howes, Harry Finch, Martin J. Drysdale, Brian Dymock, Julie E. Cansfield, Paul A. Brough, Xavier Barril, Edward McDonald, Keith Jones, Andrew Kalusa, Kwai-Ming Cheung, Thomas P. Matthews, Karen James, Laurence Pearl, Chrisostomos Prodromou, Kathy Boxall, Frederique Urban, Vanessa Martins, Angela Hayes, Martin Rowlands, Wynne Aherne, Frances Boxall, Sharon Gowan, Alexis de Haven Brandon, Lisa Patterson, Melanie Valenti, Gary Box, Swee Y. Sharp, Florence I. Raynaud, Andy Massey, Suzanne A. Eccles
Supplementary Figure 5A-B from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c359e71b2599c480c35a886bb458fa
https://doi.org/10.1158/0008-5472.22374018.v1
https://doi.org/10.1158/0008-5472.22374018.v1
Autor:
Paul Workman, Lisa Wright, Mike Wood, Paul Webb, Alan Surgenor, Roderick E. Hubbard, Rob Howes, Harry Finch, Martin J. Drysdale, Brian Dymock, Julie E. Cansfield, Paul A. Brough, Xavier Barril, Edward McDonald, Keith Jones, Andrew Kalusa, Kwai-Ming Cheung, Thomas P. Matthews, Karen James, Laurence Pearl, Chrisostomos Prodromou, Kathy Boxall, Frederique Urban, Vanessa Martins, Angela Hayes, Martin Rowlands, Wynne Aherne, Frances Boxall, Sharon Gowan, Alexis de Haven Brandon, Lisa Patterson, Melanie Valenti, Gary Box, Swee Y. Sharp, Florence I. Raynaud, Andy Massey, Suzanne A. Eccles
Supplementary Figure 4C-D from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70392e52da4056ba10fa64678101d7df
https://doi.org/10.1158/0008-5472.22374021
https://doi.org/10.1158/0008-5472.22374021
Autor:
Paul Workman, Lisa Wright, Mike Wood, Paul Webb, Alan Surgenor, Roderick E. Hubbard, Rob Howes, Harry Finch, Martin J. Drysdale, Brian Dymock, Julie E. Cansfield, Paul A. Brough, Xavier Barril, Edward McDonald, Keith Jones, Andrew Kalusa, Kwai-Ming Cheung, Thomas P. Matthews, Karen James, Laurence Pearl, Chrisostomos Prodromou, Kathy Boxall, Frederique Urban, Vanessa Martins, Angela Hayes, Martin Rowlands, Wynne Aherne, Frances Boxall, Sharon Gowan, Alexis de Haven Brandon, Lisa Patterson, Melanie Valenti, Gary Box, Swee Y. Sharp, Florence I. Raynaud, Andy Massey, Suzanne A. Eccles
Supplementary Figure 5C-D from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0508ac48cc45ae016b4e5b73ae25d08f
https://doi.org/10.1158/0008-5472.22374015
https://doi.org/10.1158/0008-5472.22374015
Autor:
Paul Workman, Lisa Wright, Mike Wood, Paul Webb, Alan Surgenor, Roderick E. Hubbard, Rob Howes, Harry Finch, Martin J. Drysdale, Brian Dymock, Julie E. Cansfield, Paul A. Brough, Xavier Barril, Edward McDonald, Keith Jones, Andrew Kalusa, Kwai-Ming Cheung, Thomas P. Matthews, Karen James, Laurence Pearl, Chrisostomos Prodromou, Kathy Boxall, Frederique Urban, Vanessa Martins, Angela Hayes, Martin Rowlands, Wynne Aherne, Frances Boxall, Sharon Gowan, Alexis de Haven Brandon, Lisa Patterson, Melanie Valenti, Gary Box, Swee Y. Sharp, Florence I. Raynaud, Andy Massey, Suzanne A. Eccles
Supplementary Figure 2 from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e9f0e4dbec149ffe274672b8d9c47f
https://doi.org/10.1158/0008-5472.22374033.v1
https://doi.org/10.1158/0008-5472.22374033.v1