Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Julie Dusseault"'
Publikováno v:
iScience, Vol 6, Iss , Pp 22-37 (2018)
Summary: Obesity results from an excessive expansion of white adipose tissue (WAT), which is still poorly understood from an etiologic-mechanistic perspective. Here, we report that Nck1, a Src homology domain-containing adaptor, is upregulated during
Externí odkaz:
https://doaj.org/article/5c0ac1cf610443d7be079ee471a8c253
Autor:
Darshana Jani, Robin Marsden, Michele Gunsior, Laura Schild Hay, Bethany Ward, Kyra J. Cowan, Mitra Azadeh, Breann Barker, Liching Cao, Kristin R. Closson, Kelly Coble, Sanjay L. Dholakiya, Julie Dusseault, Amanda Hays, Carina Herl, Michael E. Hodsdon, Susan C. Irvin, Susan Kirshner, Gerry Kolaitis, Nadia Kulagina, Seema Kumar, Ching Ha Lai, Francesco Lipari, Susana Liu, Keith D. Merdek, Ioana R. Moldovan, Reza Mozaffari, Luying Pan, Corina Place, Veerle Snoeck, Marta Starcevic Manning, Dennis Stocker, Magdalena Tary-Lehmann, Amy Turner, Inna Vainshtein, Daniela Verthelyi, William T. Williams, Haoheng Yan, Weili Yan, Lili Yang, Lin Yang, Jennifer Zemo, Zhandong Don Zhong
Publikováno v:
The AAPS journalReferences. 24(6)
A clear scientific and operational need exists for harmonized bioanalytical immunogenicity study reporting to facilitate communication of immunogenicity findings and expedient review by industry and health authorities. To address these key bioanalyti
Publikováno v:
iScience, Vol 6, Iss, Pp 22-37 (2018)
Summary: Obesity results from an excessive expansion of white adipose tissue (WAT), which is still poorly understood from an etiologic-mechanistic perspective. Here, we report that Nck1, a Src homology domain-containing adaptor, is upregulated during
Publikováno v:
Diabetes. 65(9)
Obesity results from an excessive expansion of white adipose tissue (WAT) from hypertrophy of preexisting adipocytes and enhancement of precursor differentiation into mature adipocytes. We report that Nck2-deficient mice display progressive increased
Publikováno v:
Acta Biomaterialia. 7:1683-1692
There is a need for better understanding of the biocompatibility of alginate-polycation microcapsules based on their physicochemical characteristics. Microcapsules composed of alginate with 44% (IntG) or 71% (HiG) guluronate, gelled with calcium (Ca)
Publikováno v:
Acta Biomaterialia. 5:3433-3440
Alginate purification has been shown to decrease the host immune response to implanted alginate-based microcapsules, but the direct effect of contaminants on islet cell survival remains unknown. Wistar rat islets were immobilized in calcium alginate
Autor:
Geneviève Langlois, Julie Dusseault, Marie-Christine Meunier, Claude Perreault, Martin Ménard, Jean-Pierre Hallé
Publikováno v:
Biomaterials. 29:917-924
Stem cells and immortalized cells have considerable therapeutic potential but present risks of malignant transformation. Cell microencapsulation allows transplantation without immunosuppression. We have developed a method for microencapsulating livin
Publikováno v:
Cell Communication and Signaling : CCS
Activation of the PI3K/Akt pathway mediates crucial cellular functions regulated by receptor tyrosine kinases, such as cell growth, proliferation, survival and metabolism. Previously, we reported that the whole-body knockout of the Src homology domai
Autor:
Susan K. Tam, Martin Ménard, Jean-Pierre Hallé, Stefania Polizu, Julie Dusseault, L'Hocine Yahia
Publikováno v:
Biomaterials. 26:6950-6961
Alginate–poly- l -lysine–alginate (APA) microcapsules are currently being investigated as a means to immuno-isolate transplanted cells, but their biocompatibility is limited. In this study, we verified the hypothesis that poly- l -lysine (PLL), w
Autor:
Nathalie Henley, François A. Leblond, Martin Ménard, Robert Robitaille, Guillaume Jourdan, Jean-Pierre Hallé, Julie Dusseault, Josée Tessier
Publikováno v:
Biomaterials. 26:1515-1522
Microencapsulation in semi-permeable membranes protects transplanted cells against immune destruction. Microcapsule strength is critical. We describe a method to microencapsulate living cells in alginate-poly-L-lysine (PLL)-alginate membranes with co