Zobrazeno 1 - 10 of 37 pro vyhledávání: '"Julie Dunys"'
1
Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer’s disease (AD) mouse model and is increased at early stage in sporadic AD brain
Autor: Audrey Valverde, Julie Dunys, Thomas Lorivel, Delphine Debayle, Anne-Sophie Gay, Sandra Lacas-Gervais, Bernard. P. Roques, Mounia Chami, Frédéric Checler
Publikováno v: Acta Neuropathologica
Acta Neuropathologica, Springer Verlag, 2021, 141 (6), pp.823-839. ⟨10.1007/s00401-021-02308-0⟩
One of the main components of senile plaques in Alzheimer’s disease (AD)-affected brain is the Aβ peptide species harboring a pyroglutamate at position three pE3-Aβ. Several studies indicated that pE3-Aβ is toxic, prone to aggregation and serves
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40526d35b7c81346b70ec3078ff00fe5
https://hal-univ-paris.archives-ouvertes.fr/hal-03239400
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2
Are N- and C-terminally truncated Aβ species key pathological triggers in Alzheimer's disease?
Autor: Frédéric Checler, Julie Dunys, Audrey Valverde
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2018, 293 (40), pp.15419-15428. ⟨10.1074/jbc.R118.003999⟩
The histopathology of Alzheimer's disease (AD) is characterized by neuronal loss, neurofibrillary tangles, and senile plaque formation. The latter results from an exacerbated production (familial AD cases) or altered degradation (sporadic cases) of 4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f623623397be9367ba44538a30623c
https://doi.org/10.1074/jbc.r118.003999
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3
Dipeptidyl peptidase 4 contributes to Alzheimer’s disease–like defects in a mouse model and is increased in sporadic Alzheimer’s disease brains
Autor: Audrey Valverde, Julie Dunys, Thomas Lorivel, Delphine Debayle, Anne-Sophie Gay, Céline Caillava, Mounia Chami, Frédéric Checler
Publikováno v: The Journal of Biological Chemistry
The amyloid cascade hypothesis, which proposes a prominent role for full-length amyloid β peptides in Alzheimer's disease, is currently being questioned. In addition to full-length amyloid β peptide, several N-terminally truncated fragments of amyl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f040c324fd42d8ce95f450bde8667be8
https://doi.org/10.1016/j.jbc.2021.100963
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4
The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model
Autor: Eric Duplan, Moustapha Cisse, Charlotte Bauer, T Lorivel, Y Gerakis, Julie Dunys, Inger Lauritzen, Xavier Meckler, Frédéric Checler
Publikováno v: Molecular Psychiatry
Neuronal network dysfunction and cognitive decline constitute the most prominent features of Alzheimer’s disease (AD), although mechanisms causing such impairments are yet to be determined. Here we report that virus-mediated delivery of the active
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908fc686ff81f7c4a32642bf48bb3602
https://doi.org/10.1038/mp.2016.152
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5
Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1
Autor: Frédéric Checler, Charlotte Bauer, Yannis Gerakis, Julie Dunys
Publikováno v: Scientific Reports
The aspartyl protease β-site APP cleaving enzyme, BACE1, is the rate-limiting enzyme involved in the production of amyloid-β peptide, which accumulates in both sporadic and familial cases of Alzheimer’s disease and is at the center of gravity of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6cbb84cb64bebace85f6be84c67f5f2
https://doi.org/10.1038/srep37436
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6
p53, a Pivotal Effector of a Functional Cross-Talk Linking Presenilins and Pen-2
Autor: Frédéric Checler, Julie Dunys
Publikováno v: Neurodegenerative Diseases
Neurodegenerative Diseases, Karger, 2012, 10 (1-4), pp.52-5. ⟨10.1159/000332935⟩
International audience; The γ-secretase is a multiprotein complex responsible for the ultimate cut yielding amyloid-β peptides and their N-terminal truncated species. This complex is composed of at least four distinct entities, namely presenilin-1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac44e13ed25499dd2b8c858b3b07dab
https://doi.org/10.1159/000332935
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7
Neprilysin activity and expression are controlled by nicastrin
Autor: Raphaëlle Pardossi-Piquard, Frédéric Checler, C. Alves da Costa, Julie Dunys, P. St. George-Hyslop, Gang Yu
Publikováno v: Journal of Neurochemistry
Journal of Neurochemistry, Wiley, 2006, 97, pp.1052-1056
We recently demonstrated that the presenilin-dependent gamma-secretase complex regulates the expression and activity of neprilysin, one of the main enzymes that degrade the amyloid beta-peptide (Abeta) which accumulates in Alzheimer's disease. Here,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7986e63b7f72baef2174db0334eae59
https://doi.org/10.1111/j.1471-4159.2006.03822.x
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8
The transcription factor X-box binding protein-1 in neurodegenerative diseases
Autor: Frédéric Checler, Eric Duplan, Julie Dunys
Publikováno v: Molecular Neurodegeneration
Endoplasmic reticulum (ER) is the cellular compartment where secreted and integral membrane proteins are folded and matured. The accumulation of unfolded or misfolded proteins triggers a stress that is physiologically controlled by an adaptative prot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fd6d72ec7f0056711527b520eddfb2
https://doi.org/10.1186/1750-1326-9-35
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9
The -Secretase-Derived C-Terminal Fragment of APP, C99, But Not A , Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus
Autor: Raphaëlle Pardossi-Piquard, P. St-George-Hyslop, Jean-Daniel Abraham, Linda Chami, Paul E. Fraser, Charlotte Bauer, Julie Dunys, E. Brigham, Inger Lauritzen, Frédéric Checler, Sébastien Ranaldi, V. Espin, O. Le Thuc
Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2012, 32 (46), pp.16243-16255. ⟨10.1523/JNEUROSCI.2775-12.2012⟩
Triple-transgenic mice (3xTgAD) overexpressing Swedish-mutated β-amyloiḍprecursoṛprotein (βAPPswe), P310L-Tau (TauP301L) and physiological levels of M146V-presenilin-1 (PS1M146V) display extracellular amyloid-β peptides (Aβ) deposits and Tau
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b8021611498106b77ca8a90d7ff195
https://hal.archives-ouvertes.fr/hal-02361307/document
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10
Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors
Autor: Zhiping Shao, Nikolaos K. Robakis, Julien Bruban, Jindong Xu, Junichi Shioi, Julie Dunys, Anastasios Georgakopoulos, Gweltas Mauger, Yimin Ren, Gael Barthet, Zhao Xuan, Nicolas Arbez
Publikováno v: Neurobiology of aging. 34(2)
Activation of EphB receptors by ephrinB (efnB) ligands on neuronal cell surface regulates important functions, including neurite outgrowth, axonal guidance, and synaptic plasticity. Here, we show that efnB rescues primary cortical neuronal cultures f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea01fb687273bfaa6368c85e675568e7
https://pubmed.ncbi.nlm.nih.gov/22475621
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